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WorksheetsThyroid / parathyroid
Total questions: 21
Worksheet time: 11mins
You are seeing your patient for her 2-year follow-up after total thyroidectomy for a T1 N0 M0 papillary thyroid cancer. You note that her thyroglobulin has increased from undetectable (<0.1) to 1.1 within 1 year and similar TSH levels. Which of the following is the most appropriate next step in management?
Indium-octreotide scintigraphy
PET scan to assess for metastasis
Thyroid hormone withdrawal to evaluate stimulated thyroglobulin levels
Computed tomography with IV contrast to evaluate for local and distant metastasis
Us of the neck
In patients with pseudohypoparathyroidism, associated findings include
reduced parathyroid hormone levels
target tissue resistance to parathyroid hormone
abnormally sensitive parathyroid function
normal skeletal development
paradoxic hypercalcemia
A 35-year-old woman presents with palpitations, anxiety, and insomnia. Recently postpartum, she is currently breastfeeding. What are your treatment
Alpha blockade
Beta blockade
Propylthiouracil
Levothyroxine
The administration of 99mtechnetium sestamibi
should be reserved for patients with suspected mediastinal parathyroid glands
can be used to ablate residual metaplastic parathyroid tissue
can be useful to localize abnormal parathyroid glands
should be avoided in patients with pheochromocytoma
is based on the ability of normal parathyroid glands to take up sestamibi to a greater extent than abnormal glands
Which of the following patients with thyroid gland enlargement is LEAST likely to have a diagnosis of thyroid cancer?
An elderly man with a solitary nodule and hoarseness
A young man with normal thyroid tissue in a biopsy specimen of a lateral cervical lymph node
An adolescent boy with an asymptomatic solitary nodule
A middle-aged woman with a solitary nodule and a history of radiation therapy to the neck
A middle-aged woman with a multinodular goiter and dysphagia
Lower glands are typically medial to the nerve, near the lower pole of the thyroid gland and tend to be anterior or superficial in the neck. Upper glands are lateral to the nerve, deep in the neck, and often are found near the tubercle of Zuckerlandl. The recurrent nerve is typically found in the tracheo-esophageal groove. Sometimes, upper glands can be found in the retroesophageal location, but this would be atypical for an inferior gland.
Medial to the recurrent laryngeal nerve
Lateral to the recurrent laryngeal nerve
Posterior to the esophagus
Near the tubercle of Zuckerkandl
A 40-year-old woman has a 2-cm nodule in the left lobe of the thyroid gland. She is euthyroid. Fine-needle aspiration yields indeterminate cytology
exogenous thyroid hormone suppression
left thyroid lobectomy
repeat fine-needle aspiration
observation and careful follow-up
total thyroidectomy
A 26-year-old man is found to have a 1.8-cm left thyroid nodule. Neck ulltrasound is unremarkable. Fine needle aspiration reveals a follicular lesion. What is the appropriate surgical management for this patient?
Total thyroidectomy
Reassurance and no further intervention
Total thyroidectomy with left central neck dissection
Left thyroid lobectomy
Calcitonin is
administered orally when used clinically
given to increase the serum calcium level in hypocalcemic patients
a part of the amine- or peptide-secreting system
used to monitor recurrence of follicular carcinoma of the thyroid gland
produced by the delta cells of the thyroid gland
A 37-year-old female is found to have a 0.7-cm right thyroid nodule. An FNA is performed and reveals an indeterminate follicular lesion. A right thyroid lobectomy is then performed. The right recurrent laryngeal nerve and both right parathyroid glands are identified and preserved. Postoperatively, she does well and is discharged home the next day. In follow up in the office after 10 days, pathology reveals no malignancy in the specimen. On further questioning, she reports fatigue. Which of the following laboratory tests should be ordered?
Intact parathyroid hormone
Complete blood count
Thyroid stimulating hormone (thyrotropin)
Calcium
Vitamin D
A 60-year-old female notices a small, firm, non-mobile mass on her anterior neck that has rapidly increased in size. She has developed mild dyspnea on exertion and has a history of hypothyroidism. A fine needle aspiration (FNA) and immunophenotypic analysis showing large and irregular lymphoid cells confirm the diagnosis. What is the appropriate management of her disease?
Chemotherapy and radiation
Total thyroidectomy with neoadjuvant chemotherapy
Total thyroidectomy followed by radiation
Chemotherapy alone
Total thyroidectomy with modified radical neck dissection
A 44-year-old man has a total thyroidectomy for medullary thyroid carcinoma. The most sensitive postoperative screening test for residual or recurrent tumor would be
basal plasma calcitonin levels
pentagastrin-stimulated peak plasma calcitonin levels
selective venous sampling for calcitonin levels
serum calcium levels
Bcl-2 immunoreactivity
Which muscles are encountered, in order from skin to thyroid, as you perform the exposure for a thyroidectomy?
Sternocleidomastoid, sternothyroid, sternohyoid
Platysma, sternothyroid, sternohyoid
Platysma, sternohyoid, sternothyroid
Platysma, sternocleidomastoid, sternohyoid
A 55-year-old female comes to the office for consideration of a parathyroidectomy. A parathyroid adenoma was found after routine annual laboratory values were abnormal. Her serum calcium level is 11.4 mg/dL (N = 8.5-10.2 mg/dL), PTH is 70 (N = 10-65 pg/dL), and bone density T-score is -3.0. Urinalysis showed microhematuria on a dipstick. Urinary calcium is 200 mg/24 h (N = 20-275 mg/24 hr). Which of the following, according to the NIH, is an indication for parathyroidectomy in this patient?
Mildly reduced bone mass with a bone density T-score of –0.5
Hematuria
Normal 24-hour urinary calcium excretion with an elevated serum calcium level
Patient age > 50 years
Calcium level > 1.0 mg/dL above normal
Ultrasound findings suggestive of a malignant thyroid nodule include all of the following EXCEPT
Heterogenous interior
Microcalcifications
Hypervascularity
Hyperechoic interior
Evidence of suspicious cervical lymphadenopathy
You are performing a four-gland parathyroidectomy for parathyroid hyperplasia, and cannot locate the right inferior parathyroid gland. Three glands were identified and confirmed on frozen section. Which of the following maneuvers should be your next step?
Ligate and divide the right middle thyroid vein
Perform a right thyroid lobectomy
It is not imperative to locate the gland at this time
Examine the thymic pedicle and resect
Perform a median sternotomy
All of the following are indicators of tumor aggressiveness and poor outcome for papillary carcinoma of the thyroid EXCEPT:
tumor larger than 4 cm
microscopic lymph node metastasis
invasion through capsule to adjacent tissues
poorly differentiated histologic grade
age over 50
A 56-year-old woman was found to have a palpable lateral neck level 4 lymph node. Biopsy shows metastatic papillary thyroid cancer. CT of the neck, chest, abdomen, and pelvis shows no other metastatic lesions. What is the best surgical option for this patient?
Total thyroidectomy and left lateral neck dissection
Total thyroidectomy, central neck and left lateral neck dissection
Subtotal thyroidectomy, central neck and segmental left level 4 neck dissection
Thyroid lobectomy, resection of gross disease in the central and left lateral neck
Total thyroidectomy and resection of gross disease in the lateral neck
A 60-year-old woman with primary hyperparathyroidism is considering surgery. After you confirm the diagnosis and indications for surgery, you proceed with surgical planning. Which of the following localizing studies is indicated in this patient?
99mTechnetium sestamibi scan and ultrasound of the neck
4-D CT scanning to identify the normal glands
MRI and PET scan
Radioactive iodine scan
Selective venous sampling for PTH during initial surgery to secure the location of the adenoma
A 42-year-old man is undergoing neck exploration because of hypercalcemia (12.0 mg/dL) and an elevated PTH level (220 pg/dL) which was discovered when he was evaluated for recurrent urolithiasis and fatigue. He has a 20 pack-year smoking history. He takes no medications. His 87-year-old maternal grandmother had a history of thyroid cancer diagnosed when she was 26, and there is no other family history of endocrine disorders or cancer. Ultrasonography and sestamibi scanning show a 1.5-cm solitary lesion in the area of the right superior thyroid lobe. Chest x-ray shows only mild emphysema. At surgery, there is a firm 1.5-cm mass posterior to the right lobe of the thyroid just superior to the middle thyroid vein that is inseparable from the thyroid. There is an enlarged adjacent lymph node. Histology of this mass will likely show which of the following?
A single focus of chief cells, surrounded by a compressed rim of normal tissue
A diffuse proliferation of clear cells with little remaining normal tissue
Marked mitotic activity, dense fibrous stroma, and evidence of local invasion into the capsule or surrounding vessels
The presence of C cell hyperplasia and dispersed plasmacytoid cells with sudden anisonucleosis
The presence of Reed-Sternberg cells
A 13-year-old girl was found to have a solitary neck mass by her mother. You evaluate her and confirm that it is a thyroid nodule. The mother asks you if she has cancer. Which of the following is the best response?
Thyroid nodules are very common, but the cancer risk is less than 15% for this age group
She likely has cancer, and given her young age, she most likely has medullary thyroid cancer and multiple endocrine neoplasia
She has a very high risk of medullary thyroid cancer; therefore, you recommend a total thyroidectomy and prophylactic bilateral central neck dissection.
Her risk of cancer is nearly 50% and additional testing is recommended to confirm it.
The risk of cancer is low and no further testing is needed
