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Thyroid / parathyroid

Total questions: 21

Worksheet time: 11mins

Name
Class
Date
1.

You are seeing your patient for her 2-year follow-up after total thyroidectomy for a T1 N0 M0 papillary thyroid cancer. You note that her thyroglobulin has increased from undetectable (<0.1) to 1.1 within 1 year and similar TSH levels. Which of the following is the most appropriate next step in management?

a)

Indium-octreotide scintigraphy

b)

PET scan to assess for metastasis

c)

Thyroid hormone withdrawal to evaluate stimulated thyroglobulin levels

d)

Computed tomography with IV contrast to evaluate for local and distant metastasis

e)

Us of the neck

2.

In patients with pseudohypoparathyroidism, associated findings include

a)

reduced parathyroid hormone levels

b)

target tissue resistance to parathyroid hormone

c)

abnormally sensitive parathyroid function

d)

normal skeletal development

e)

paradoxic hypercalcemia

3.

A 35-year-old woman presents with palpitations, anxiety, and insomnia. Recently postpartum, she is currently breastfeeding. What are your treatment

a)

Alpha blockade

b)

Beta blockade

c)

Propylthiouracil

d)

Levothyroxine

4.

The administration of 99mtechnetium sestamibi

a)

should be reserved for patients with suspected mediastinal parathyroid glands

b)

can be used to ablate residual metaplastic parathyroid tissue

c)

can be useful to localize abnormal parathyroid glands

d)

should be avoided in patients with pheochromocytoma

e)

is based on the ability of normal parathyroid glands to take up sestamibi to a greater extent than abnormal glands

5.

Which of the following patients with thyroid gland enlargement is LEAST likely to have a diagnosis of thyroid cancer?

a)

An elderly man with a solitary nodule and hoarseness

b)

A young man with normal thyroid tissue in a biopsy specimen of a lateral cervical lymph node

c)

An adolescent boy with an asymptomatic solitary nodule

d)

A middle-aged woman with a solitary nodule and a history of radiation therapy to the neck

e)

A middle-aged woman with a multinodular goiter and dysphagia

6.

Lower glands are typically medial to the nerve, near the lower pole of the thyroid gland and tend to be anterior or superficial in the neck. Upper glands are lateral to the nerve, deep in the neck, and often are found near the tubercle of Zuckerlandl. The recurrent nerve is typically found in the tracheo-esophageal groove. Sometimes, upper glands can be found in the retroesophageal location, but this would be atypical for an inferior gland.

a)

Medial to the recurrent laryngeal nerve

b)

Lateral to the recurrent laryngeal nerve

c)

Posterior to the esophagus

d)

Near the tubercle of Zuckerkandl

7.

A 40-year-old woman has a 2-cm nodule in the left lobe of the thyroid gland. She is euthyroid. Fine-needle aspiration yields indeterminate cytology

a)

exogenous thyroid hormone suppression

b)

left thyroid lobectomy

c)

repeat fine-needle aspiration

d)

observation and careful follow-up

e)

total thyroidectomy

8.

A 26-year-old man is found to have a 1.8-cm left thyroid nodule. Neck ulltrasound is unremarkable. Fine needle aspiration reveals a follicular lesion. What is the appropriate surgical management for this patient?

a)

Total thyroidectomy

b)

Reassurance and no further intervention

c)

Total thyroidectomy with left central neck dissection

d)

Left thyroid lobectomy

9.

Calcitonin is

a)

administered orally when used clinically

b)

given to increase the serum calcium level in hypocalcemic patients

c)

a part of the amine- or peptide-secreting system

d)

used to monitor recurrence of follicular carcinoma of the thyroid gland

e)

produced by the delta cells of the thyroid gland

10.

A 37-year-old female is found to have a 0.7-cm right thyroid nodule. An FNA is performed and reveals an indeterminate follicular lesion. A right thyroid lobectomy is then performed. The right recurrent laryngeal nerve and both right parathyroid glands are identified and preserved. Postoperatively, she does well and is discharged home the next day. In follow up in the office after 10 days, pathology reveals no malignancy in the specimen. On further questioning, she reports fatigue. Which of the following laboratory tests should be ordered?

a)

Intact parathyroid hormone

b)

Complete blood count

c)

Thyroid stimulating hormone (thyrotropin)

d)

Calcium

e)

Vitamin D

11.

A 60-year-old female notices a small, firm, non-mobile mass on her anterior neck that has rapidly increased in size. She has developed mild dyspnea on exertion and has a history of hypothyroidism. A fine needle aspiration (FNA) and immunophenotypic analysis showing large and irregular lymphoid cells confirm the diagnosis. What is the appropriate management of her disease?

a)

Chemotherapy and radiation

b)

Total thyroidectomy with neoadjuvant chemotherapy

c)

Total thyroidectomy followed by radiation

d)

Chemotherapy alone

e)

Total thyroidectomy with modified radical neck dissection

12.

A 44-year-old man has a total thyroidectomy for medullary thyroid carcinoma. The most sensitive postoperative screening test for residual or recurrent tumor would be

a)

basal plasma calcitonin levels

b)

pentagastrin-stimulated peak plasma calcitonin levels

c)

selective venous sampling for calcitonin levels

d)

serum calcium levels

e)

Bcl-2 immunoreactivity

13.

Which muscles are encountered, in order from skin to thyroid, as you perform the exposure for a thyroidectomy?

a)

Sternocleidomastoid, sternothyroid, sternohyoid

b)

Platysma, sternothyroid, sternohyoid

c)

Platysma, sternohyoid, sternothyroid

d)

Platysma, sternocleidomastoid, sternohyoid

14.

A 55-year-old female comes to the office for consideration of a parathyroidectomy. A parathyroid adenoma was found after routine annual laboratory values were abnormal. Her serum calcium level is 11.4 mg/dL (N = 8.5-10.2 mg/dL), PTH is 70 (N = 10-65 pg/dL), and bone density T-score is -3.0. Urinalysis showed microhematuria on a dipstick. Urinary calcium is 200 mg/24 h (N = 20-275 mg/24 hr). Which of the following, according to the NIH, is an indication for parathyroidectomy in this patient?

a)

Mildly reduced bone mass with a bone density T-score of –0.5

b)

Hematuria

c)

Normal 24-hour urinary calcium excretion with an elevated serum calcium level

d)

Patient age > 50 years

e)

Calcium level > 1.0 mg/dL above normal

15.

Ultrasound findings suggestive of a malignant thyroid nodule include all of the following EXCEPT

a)

Heterogenous interior

b)

Microcalcifications

c)

Hypervascularity

d)

Hyperechoic interior

e)

Evidence of suspicious cervical lymphadenopathy

16.

You are performing a four-gland parathyroidectomy for parathyroid hyperplasia, and cannot locate the right inferior parathyroid gland. Three glands were identified and confirmed on frozen section. Which of the following maneuvers should be your next step?

a)

Ligate and divide the right middle thyroid vein

b)

Perform a right thyroid lobectomy

c)

It is not imperative to locate the gland at this time

d)

Examine the thymic pedicle and resect

e)

Perform a median sternotomy

17.

All of the following are indicators of tumor aggressiveness and poor outcome for papillary carcinoma of the thyroid EXCEPT:

a)

tumor larger than 4 cm

b)

microscopic lymph node metastasis

c)

invasion through capsule to adjacent tissues

d)

poorly differentiated histologic grade

e)

age over 50

18.

A 56-year-old woman was found to have a palpable lateral neck level 4 lymph node. Biopsy shows metastatic papillary thyroid cancer. CT of the neck, chest, abdomen, and pelvis shows no other metastatic lesions. What is the best surgical option for this patient?

a)

Total thyroidectomy and left lateral neck dissection

b)

Total thyroidectomy, central neck and left lateral neck dissection

c)

Subtotal thyroidectomy, central neck and segmental left level 4 neck dissection

d)

Thyroid lobectomy, resection of gross disease in the central and left lateral neck

e)

Total thyroidectomy and resection of gross disease in the lateral neck

19.

A 60-year-old woman with primary hyperparathyroidism is considering surgery. After you confirm the diagnosis and indications for surgery, you proceed with surgical planning. Which of the following localizing studies is indicated in this patient?

a)

99mTechnetium sestamibi scan and ultrasound of the neck

b)

4-D CT scanning to identify the normal glands

c)

MRI and PET scan

d)

Radioactive iodine scan

e)

Selective venous sampling for PTH during initial surgery to secure the location of the adenoma

20.

A 42-year-old man is undergoing neck exploration because of hypercalcemia (12.0 mg/dL) and an elevated PTH level (220 pg/dL) which was discovered when he was evaluated for recurrent urolithiasis and fatigue. He has a 20 pack-year smoking history. He takes no medications. His 87-year-old maternal grandmother had a history of thyroid cancer diagnosed when she was 26, and there is no other family history of endocrine disorders or cancer. Ultrasonography and sestamibi scanning show a 1.5-cm solitary lesion in the area of the right superior thyroid lobe. Chest x-ray shows only mild emphysema. At surgery, there is a firm 1.5-cm mass posterior to the right lobe of the thyroid just superior to the middle thyroid vein that is inseparable from the thyroid. There is an enlarged adjacent lymph node. Histology of this mass will likely show which of the following?

a)

A single focus of chief cells, surrounded by a compressed rim of normal tissue

b)

A diffuse proliferation of clear cells with little remaining normal tissue

c)

Marked mitotic activity, dense fibrous stroma, and evidence of local invasion into the capsule or surrounding vessels

d)

The presence of C cell hyperplasia and dispersed plasmacytoid cells with sudden anisonucleosis

e)

The presence of Reed-Sternberg cells

21.

A 13-year-old girl was found to have a solitary neck mass by her mother. You evaluate her and confirm that it is a thyroid nodule. The mother asks you if she has cancer. Which of the following is the best response?

a)

Thyroid nodules are very common, but the cancer risk is less than 15% for this age group

b)

She likely has cancer, and given her young age, she most likely has medullary thyroid cancer and multiple endocrine neoplasia

c)

She has a very high risk of medullary thyroid cancer; therefore, you recommend a total thyroidectomy and prophylactic bilateral central neck dissection.

d)

Her risk of cancer is nearly 50% and additional testing is recommended to confirm it.

e)

The risk of cancer is low and no further testing is needed