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WorksheetsPharmacology of Quinolones
Total questions: 11
Worksheet time: 4mins
How different is the MOA of fluoroquinolones in G+ and G- microbes?
In G+ve, more activity towards DNA gyrase
In G-ve - more activity towards DNA gyrase
In G+ve, more activity towards topoisomerase IV
In G-ve, more activity towards topoisomerase IV
No difference
How many generations of quinolones that have been currently listed?
Two (2)
Three (3)
Four (4)
Five (5)
Which of the following is NOT the mechanism of resistance to fluoroquinolones?
Alterations in DNA gyrase
Alterations in topoisomerase IV
Increase influx of drugs
Decrease uptake of drug
The first drug under quinolone group is
clavulanic acid
fluoroacetic acid
nalidixic acid
naxidilic acid
Which of the following is the primary excretion route for most fluoroquinolones?
Renal
Liver
Skin
Which of the following agent is not primarily excreted via renal?
Ciprofloxacin
Norfloxacin
Levofloxacin
Moxifloxacin
Which of the following agent should be highly monitored in patients with kidney impairment?
Levofloxacin
Moxifloxacin
Grepafloxacin
Multivalent cation-containing products may reduce the absorption of fluoroquinolones.
True
False
CIprofloxacin and pefloxacin may interact with theophylline through involvement of CYP450.
True
False
Which of the agents have effect on cardiovascular?
Levofloxacin
Sparfloxacin
Moxifloxacin
Gatifloxacin
What type of cardiovascular effect do some of the fluoroquinolone cause?
Increased blood pressure
Reduced heart rate
Prolonged QTc interval
