WorksheetsHypersensitivity Immunology
Total questions: 79
Worksheet time: 40mins
Immediate Hypersensitivity is which type
I
II
III
IV
Which cells are important for type I hypersensitivity?
mast cells
neutrophils
antibodies
leukocytes
Which is NOT a feature of type I hypersensitivity?
atopy
response time lags
exaggerated Th2
Excessive IgE
Which factors would make you more susceptible to Atopy?
High genetic susceptibility
low genetic susceptibility
less hygienic
more hygienic
Which immunoglobulin is bound to the surface in type I to cross link and degranulate host cell?
IgA
IgM
IgG
IgE
Which interleukin is important for the induction of IgE response in type I sensitivity?
IL-4
IL-12
IFN-y
IL-5
IL-12 and IFN-y induce what action in type I
Inhibit IL-4 response
Promote IL-4 response
Promote T cell proliferation
inhibit t cell proliferation
"Metachromic" intense staining occurs in which cell type?
mast cells
lymphocytes
b cells
NK cells
The binding of which is indicative of rapid, complete degraulation
IgE
IgG
neuropeptides
adenosine
Which is not a response of IgE cross-linking?
cytokine synthesis and secretion
granule exocytosis
prostoglandin and leukotriene synthesis
phagocytosis of target cells
Which is not an action of granule exocytosis?
vascular dilation
smooth muscle contraction
tissue damage
leukocyte recruitment
Which mast cell mediator is solely responsible for smooth muscle contraction?
protaglandin
proteases
leukotrienes
cytokines
which occurs in the late phase of type I hypersensitivity?
cytokines
vasoactive amines
lipid mediators
mast cells
Which cell type is in the second phase of type I?
Eosinophils
Mast cells
Which interleukin mobiles eosinophils for the second phase?
Il-3
IL-2
IL-4
IL-5
allergic rhinitis, food allergies, bronchial asthma, and anaphylaxis are all indicative of
type I
type II
type III
type IV
Urticaria or local dermatitis is indicitive of which type hypersensitivity?
type I
type II
type III
type IV
With the exception of the dog and cat, which organ system is mostly affected with type I?
respiratory
hepatic
GI
renal
Which system is affected in anaphylaxis in dog?
respiratory tract
heptic
GI
renal
Which type of hypersensitivity is antibody mediated?
Type I
Type II
Type III
Type IV
Which immunoglobulins are important in Type II?
IgE
IgA
IgM
IgG
Reaction to drugs, blood transfusions, or neonatal hemolytic erthrolysis are examples of which type?
Type I
Type II
Type III
Type IV
Antibody mediated is also called
cytotoxic mediated
immune complex mediated
t- cell mediated
Which cell type is important for type II?
mast cells
neutrophils
granulocytes
monocytes
An antibody stimulating a receptor w/o a hormone occurs in what disease?
Grave's disease
Myasthenia Gravis
Lymes's disease
T/F: animals may possess antibodies against foreign blood groups antigen even though they've never been previously exposed.
true
false
In which case would RBCs not be immediately destructed in a transfusion
in absence of preexisting antibodies
in case of second transfusion
in case of natural antibodies
in case of cross reacting epitopes
If dam and fetus have incompatible blood types the result is
HDN
ADR
DIC
RBC
Which blood type produces the most severe reaction in HDN?
AA
Qa
EAA
Q
Which mares are most likely to produce HDN foals?
that lack Aa and Qa
mares having their first foal
mares that have the Aa and Qa blood type
mares that foals are removed before suckling
Which is true about HDN in calves?
EAB and EAJ are least important
results from anaplasmosis or babesiosis vaccination
very common
they don't stimulate antibody production against blood group
which is false about bovine neonatal pancytopenia?
causes unexplained hemorrhagic disease of calves
colostrum of dams contained antibodies against MHC II antigen
traced back to BVD vaccine
Why did the hog cholera vaccine cause HDN?
it contained pig blood
it targeted MHC I
increased production of lymphocytes
because of prexposure.
Penicillin induced hemolytic anemia is common in which species?
horses
pigs
cattle
poultry
Which isn't a way that drugs and antibodies interact?
combine indirectly and activate complement
binds to cell surface of glycoproteins
can modify red cell membranes
red cells are destroyed as bystander effect
In type III hypersenstivity, what is deposited in large amounts in tissues and causes inflammation?
immune complexes
antibodies
antigen
eosinophils
the classical pathway generates what that attracts neutrophils
chemattractant peptide
mast cells
oxidants
enzymes
What is the prerequisite for development of immune complexes?
insoluble immune complexes
soluble antigen and antibody
insoluble antigen and antibody
soluble immune complexes
The most commonly affected sites of type III are all except
skin
lungs
joints
brain
liver
Onset for type III is
immediate
6-8 hrs
3-5 hrs
12-24 hrs
What is it called when excess antigen in circulation meets up w/ antibody (IgG)
local hypersensitivity
generalized/systemic
Acute inflammation will develop at the injection site within several hours in what reaction
Arthus
Arthers
Type IV
Which is not a significant feature in the mechanism of Local type III?
complement activation
neutrophil emigration
destruction of blood vessel wall
eosinophil emigration
What is Attributable to natural infection with canine adenovirus type 1
serum sickness
blue eye
Pneumonitis
Exposure to to S. rectivirgula can cause all EXECPT:
farmer's lung
pneumonitis
Acute alveolitis
systemic lupus erythematous
Which is not an example of generalized type III hypersensitivity?
serum sickness
chronic drug exposure
infectious agents
autoimmune dz.
Pneumonitis
Which doesn't influence deposition of immune complexes?
Size of the circulating immune complex
Ability of the host to clear the immune complexes from circulation
Anatomic and hemodynamic factors influence where the complexes deposit
filtration rate
Which form of Membranoproliferative Glomerulonephritis contains C3 but not Ig?
type I
type II
type III
Which type of Membranoproliferative Glomerulonephritis occurs in subepitheilial
type i
type II
type III
Which type of hypersensitivity is considered t- cell mediated?
type I
type II
type III
type IV
Type IV hypersensitivity is occurernce is
immediate
delayed
3-6 hrs post exposure
0-4 hours post exposure
Which cell type is not a component in type IV hypersensitivity
TH1 cells
cytotoxic t cells
macrophage
dendrite
Methimazole drug reaction occurs because of drug/hapten response and is which type(s)
type I
type II
type III
type IV
Which of the following is not a component of the interactions that occur in type IV?
injected antigen
APC
t-cell
antibody mediation
All are clinical examples of type IV EXCEPT:
TB reaction
contact dermatitis
gluten sensitivity
atopy
lesions in the TB reaction are infiltrated with what only during the first few hours?
neutrophils
lymphocytes
macrophages
Which tuberculin test is the most efficiency but also has the most risk of anaphylaxis?
single intradermal
comparative
short thermal
stormont
Animals infected with what may develop a delayed hypersensitivity reaction following ID injection of Johnin, an extract of this organism
MAP
SID
BID
TB
Pathological consequences of type IV are all of the following except
tubercle formation
allergic contract dermatitis
Stevens-Johnson Syndrome
hemolytic dz.
Which of the 3 mechanism of type IV occurs over the longest period?
granulomatous reactions
allergic contact dermatitis
tuberculin reaction
Which of the following is exhibited by areas of hairloss?
atopic dermatitis
allergic contact dermatitis
In Stevens-Johnson syndrome, skin ulcers due to binding of epidermal cells and triggering of what
CD95L
mast cells
dendritic cells
FAS-L
When measuring t cell proliferation (dividing vs non-dividing) you're measuring the uptake of what
H3-thymidine
HSP-thymidine
T-3
tryosine
when measuring t-cell mediated cytotoxicity (killed vs unkilled) what are you measuring
51CR
H3tyridine
3CR
51T
What are your removing before you measure Cytokine Release by T cells
cytokines like IFN-y
supernatant
lymphocytes
ELISpot Assay measures bound cytokines via
enzyme labeled antiglobulin
centrifuge
radioactivity
unbound thymidine
Allergic reaction to L-asparaginase chemotherapy within a few minutes after administration of the drug in a dog.
type I
type II
type III
type IV
Severe urticarial reaction and facial edema post vaccine administration.
type I
type II
type III
type IV
Nosebleed, bruising of skin and gums. History of sulfonamide treatment 20 days prior.
type I
type II
type III
type IV
Sudden onset of anorexia, vomiting, lethargy along with peripheral edema was observed in a Labrador six months after becoming seropositive for Borrelia burgdorferi. Further testing revealed uremia, hyperphosphatemia, and severe protein-losing nephropathy.
type I
type II
type III
type IV
3 weeks after a bout of infection with S. equi, a horse developed subcutaneous edema involving limbs and brisket, and the development of hemorrhages in the mucosa.
type I
type II
type III
type IV
Vomiting, diarrhea, hypersalivation, fever, and hemoglobinuria post blood transfusion
type I
type II
type III
type IV
An acutely depressed dog with a rapid decrease in PCV within 24-48 h with bilirubinemia, icterus, hemoglobinuria, and anemia.
type I
type II
type III
type IV
Diamond shaped skin lesions in pigs
type I
type II
type III
type IV
A foal was born healthy but became weak and depressed around 6 h after suckling. The mucus membranes of foal became icteric after 24 h. The suckling was stopped and therapy to manage the condition was started.
type I
type II
type III
type IV
Facial edema less than an hour after an insect bite
type I
type II
type III
type IV
A one-year-old, intact female, Yorkshire terrier dog presented with skin lesions, which included blisters and patchy skin loss. The condition affected the epidermis over the nose, the footpads, and the oral, pharyngeal, nasal, and conjunctival mucosa. The dog was on potentiated sulfonamides a couple of weeks ago
type IV - steven johnson syndrome
type III
type II
type I atopy
history of polyuria/polydipsia, anorexia, vomiting, and diarrhea with melena. A hematologic evaluation 3 days earlier had revealed blood urea nitrogen increase and elevated serum creatinine and antibodies to Leishmania spp. and D. immitis antigens.
type I
type II
type III
type IV
Erythema, alopecia and vesiculation on abdomen in a dog, possibly due to exposure to dyes in carpet.
type I
type II
type III
type IV
