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RADIOPHARMACEUTICAL DR. YANG EXAM 1

Total questions: 78

Worksheet time: 5hrs 41mins

Name
Class
Date
1.

A radioactive pharmaceutical agent used for diagnostic or therapeutic procedures.

a)

Nuclear medicine

b)

Radiopharmaceutical

2.

Radiopharmaceutical is composed of two parts:

a)

Institutional

b)

Pharmaceutical

c)

Radionuclide

d)

Specialty

3.

By which of the federal/state agencies is regulated Radiopharmaceutical? Select all that apply

a)

NABBP

b)

State Board of Pharmacy

c)

FDA

d)

Nuclear Regulatory Commission (NRC)

4.

Radiopharmaceutical DOES NOT have pharmacologic effect.

a)

True

b)

False

5.

RPs administered at standard dosages DO NOT produce a pharmacologic response.

a)

True

b)

False

6.

Amount of RP injected is extraordinarily small to achieve our goals.

a)

True

b)

False

7.

Amount of RP injected has to be huge quantity to achieve our goals.

a)

True

b)

False

8.

Is an atomic species characterized by the specific constitution of its nucleus.

a)

Nuclide

b)

Isotopes

9.

A set of nuclides with equal proton number (atomic number) are called ________ of the element.

a)

isotopes

b)

nucleotides

10.

The property of certain nuclides of emitting radiation by the spontaneous transformation (disintegration) of their nuclei into those of other nuclides.

a)

isotopes

b)

nucleotides

c)

radioactivity

11.

Alpha particle contains which of the following?

a)

2 protons and 1 neutron

b)

2 protons and 2 neutrons

c)

2 protons and 2 electrons

d)

2 neutrons and 2 electrons

12.

B Minus decay emits which of the following ? Select all that apply

a)

proton

b)

neutron

c)

electron

d)

antineutrino

13.

Beta Plus Decay emits which of the following ? Select all that apply

a)

positron

b)

antineutrino

c)

neutron

d)

electron neutrino

14.

Which of the following allows the atom to obtain the optimal ratio of protons and neutrons?

a)

Alpha Decay

b)

Beta Decay

c)

Beta minus Decay

d)

Beta Plus Decay

15.

Which of the following typically occurs in the heavy nuclides?

a)

Beta Decay

b)

Alpha Decay

c)

Beta Minus Decay

d)

Beta Plus Decay

16.

Which of the following is energy and represent the photons which is electromagnetic radiation?

a)

Gamma decay

b)

Beta decay

c)

Alpha Decay

d)

Beta minus Decay

17.

Which of the following removes energy from an unstable nucleus?

a)

Alpha Decay

b)

Gamma Decay

c)

Beta Decay

d)

Beta Minus Decay

e)

Beta Plus Decay

18.

Memorize this table

a)

Yes

b)

No

19.

Which of the following of the three types of decays is the most dangerous one and we must leave it away from us (at distance)?

a)

Alpha decay

b)

Beta decay

c)

Gamma decay

20.

Which of the following can penetrate only to the outside of the skin and having the weakest penetration ability?

a)

gamma decay

b)

beta decay

c)

alpha decay

21.

 

Which of the following can penetrate the entire body and thus having the strongest penetration ability?

a)

gamma decay

b)

beta decay

c)

alpha decay

22.

Which of the following decays hast the highest particle mass and particle charge?

a)

gamma decay

b)

alpha decay

c)

beta decay

23.

Which of the following decays the millimeters of aluminum can prevent damage to our body?

a)

gamma decay

b)

beta decay

c)

alpha decay

24.

In which of the following decays we must use thick lead or concrete to get protection during operation?

a)

gamma decay

b)

beta decay

c)

alpha decay

25.

Which of the following decays only become dangerous when we swallow them?

a)

beta decay

b)

alpha decay

c)

gamma decay

26.

The quantity of radioactive material, expressed as the number of radioactive atoms undergoing nuclear transformation per unit time.

a)

nuclide

b)

isotope

c)

activity

27.

Activity is traditionally expressed in units of ?

a)

photons

b)

Ln (gamma receptor)

c)

curies (Ci)

d)

time

28.

In the SI Unit system the unit for radioactivity is which of the following?

a)

curies (Ci)

b)

becquerel (Bq)

c)

time -1 unit

29.

1 mCi equals how many MBq?

a)

37

b)

33

c)

34

d)

30

30.

Decay is which of the following order reactions?

a)

first order

b)

zero order

31.

Physical half-life and decay constant are inversely related and unique for each radionuclide.

a)

True

b)

False

32.

99mTc has a half life of 6 hours, determine the fraction remaining after 12 hours?

a)

12.5%

b)

25%

c)

50%

d)

75%

33.

A radiopharmaceutical has a physical half- life of 3 hours and a biological half-life of 12 hours, calculate its effective half-life?

a)

0.42 hour

b)

1.2 hours

c)

2.4 hours

d)

7.5 hours

34.

What are the parameters to monitor in Radiopharmaceuticals? Select all that apply

a)

sterility

b)

purity

c)

pH

d)

stability

35.

Radiochemical purity may change with time.

a)

True

b)

False

36.

Beta-emitting nuclides are usually used for?

a)

therapeutic

b)

diagnostic

37.

Gamma-emitting nuclides are usually used for?

a)

diagnostic

b)

therapeutic

38.

Which of the following statements are TRUE about Diagnostic types in Radiopharmaceuticals? Select all that apply

a)

Dynamic and static information available

b)

Gamma-emitting nuclides

c)

No physiological effect

d)

Beta-emitting nuclides

e)

Particles that will damage tissue

39.

 

Which of the following statements are TRUE about Therapeutic types in Radiopharmaceuticals? Select all that apply

a)

Beta-emitting nuclides

b)

Particles that will damage tissue

c)

Gamma-emitting nuclides

d)

No physiologic effect

e)

Dynamic and static information available

40.

All of the following statements are true about Diagnostic in radiopharmaceuticals, EXCEPT?

a)

Gamma-emitting nuclides

b)

Particles that will damage tissue

c)

Dynamic and static information available

d)

No physiologic effect

41.

Which of the following are considered Ideal Diagnostic Radiopharmaceutical? Select all that apply

a)

can access organ/system

b)

emits GAMMA rays

c)

short-half life and has an emission energy between 100-250 keV

d)

quick metabolism/excretion

e)

has NO pharmacological action

42.

Oxygen as a Biopharmaceutical?

a)

application in cerebral oxygen extraction; metabolism

b)

application in tumor glucose metabolism

43.

Fluorodeoxyglucose as a Biopharmaceutical? Select all that apply

a)

application in tumor glucose metabolism

b)

application in cerebral oxygen extraction; metabolism

44.

N-methyl spiperone as a Biopharmaceutical?

a)

application in tumor glucose mteabolism

b)

application as dopamine receptor binding

45.

[C]-acetate as a Biopharmaceutical?

a)

application myocardial glucose metabolism

b)

application in myocardial metabolism

46.

Dr. Yang said memorize this table from left to right. Questions were made in this Quiziz regarding this table.

a)

Yes

b)

No

47.

Which of the following are the uses of PET scan? Select all that apply

a)

determine the effects of heart attack, myocardial infarction or heart areas.

b)

brain abnormalities, such as tumors, memory disorders, seizures and central nervous system disorders.

c)

detect cancer

d)

detect viruses in the body

48.

Which of the following is the BRAND name for 99mTc exametazime used in cerebral perfusion, radiolabeling autologous leukocytes?

a)

Ceretec

b)

Pulmonite

c)

Choletec

d)

Techneplex

e)

Ultratag

49.

Which of the following is the BRAND name for 99mTc macroaggregated used in pulmonary perfusion albumin?

a)

Choletec

b)

Pulmonite

c)

Ceretec

d)

Ultratag

50.

Which of the following is the BRAND name for 99mTc mebrofenin used in hepatobiliary imaging?

a)

Ceretec

b)

Pulmonite

c)

Choletec

d)

Techneplex

e)

Ultratag

51.

Which of the following is the BRAND name for 99mTc mertiatide used in renal imaging?

a)

Technescan MAG3

b)

Techneplex

c)

Ultratag

d)

Choletec

e)

Pulmonite

52.

Which of the following is the BRAND name for 99mTc pentetate (DTPA) used in radio aerosol ventilation imaging?

a)

Techneplex, Technescan DTPA

b)

Choletec

c)

Ceretec

d)

Pulmonite

e)

Technescan MAG3

53.

Which of the following is the BRAND name for 99mTc red blood cells used in imaging in gastrointestinal bleeding, cardiac chambers, cardia first pass, gated equilibrium imaging?

a)

Ceretec

b)

Pulmonite

c)

Techneplex

d)

Ultratag

54.

Which of the following is the BRAND name for 99mTc oxidronate (HDP) used in bone imaging?

a)

Technescan MAG3

b)

OctreoScan HDP

c)

Technescan DTPA

d)

Ultratag

55.

Which of the following is the BRAND name for 99mTc sestamibi used in imaging of breast tumor?

a)

Ceretec

b)

Cardiolite, Miraluma

c)

Ultratag

d)

Pulmonite

56.

Which of the following is the BRAND name for 111 In capromab pendetide used in monoclonal antibody for imaging prostate cancer ?

a)

Bexxar

b)

OctreoScan

c)

ProstaScint

d)

Indium-111 Oxine

57.

Which of the following is the BRAND name for 131 I tositumomab used in treatment of non-Hodgkin lymphoma?

a)

Bexxar

b)

Zevalin

c)

Ultratag

d)

ProstaScint

58.

Which of the following is the BRAND name for 90Y microspheres used in therapy for biopsy proven, unresectable hepatocellular carcinoma?

a)

Zevalin

b)

Quadramet

c)

TheraSphere

d)

Myoview

59.

Which of the following is the BRAND name for 153Sm-lexidronam (EDTMP) used in palliation of bone pain of skeletal metastases?

a)

Quadramet

b)

Zevalin

c)

Myoview

d)

TheraSphere

60.

Which of the following are used as bone cancer therapy? Select all that apply

a)

166Ho-DOTMP

b)

Zevalin

c)

186Re-HEDP

d)

Quadramet

e)

Dupont Xenon

61.

Which of the following radiopharmaceutical drugs are for the treatment of Non-Hodgkin lymphoma? Select all that apply

a)

Bexxar

b)

Zevalin

c)

Ceretec

d)

Pulmonite

e)

ProstaScint

62.

Which of the following radio isotope is used is mostly used in diagnostic imaging studies?

a)

111 In

b)

90Y

c)

Technetium-99m (99mTc)

d)

131 I

63.

What is the half-life of Technetium-99m (99mTc)?

a)

12 hours

b)

6 hours

c)

15 hours

d)

22 hours

64.

Which of the following statements are TRUE about Technetium-99m (99mTc)? Select all that apply

a)

half-life is 6 hours

b)

only Gamma emission

c)

flexible chemistry profile

d)

140 Kev

e)

manufactured commercially available kits

65.

99mTc is usually used in diagnostics.

a)

True

b)

False

66.

What are the typical ingredients in Cold Kits? Select all that apply

a)

methylene diphosphonate (MDP)

b)

Stabilizers, buffers, antioxidants, bactericides

67.

What is the compound to be complexed to the Tc-99m in Cold Kits?

a)

methylcellulose (MCC)

b)

methylene diphosphonate (MDP)

68.

Which of the following radionuclides is a REACTOR in production?

a)

Tc99m

b)

I131

c)

F18

d)

In111

e)

I123

69.

Which of the following radionuclides is a GENERATOR in production?

a)

I123

b)

I131

c)

Tc99m

d)

In111

e)

F18

70.

Which of the following radionuclides are CYCLOTRON/ACCELERATOR in production? Select all that apply

a)

I123

b)

In111

c)

F18

d)

Tc99m

e)

I131

71.

When keeping and disposal of radioactive substances, which of the following statements are TRUE? Select all that apply

a)

EPR Certificates for storage and disposal of radioactive materials

b)

Properly designed stores

c)

Stock Records

d)

Reports to be sent to the Environment Agency (Solid waste for incineration, solid waste to landfill, aqueous waste to drains.)

72.

Which of the following are TRUE when transporting Radioactive materials? Select all that apply

a)

Controlled under Carriage of Dangerous Goods 2009

b)

Drivers need to be trained

c)

Vehicles need to be  marked

d)

Emergency kits and instructions

73.

Which of the following packaging is used to transport very small quantity of radiopharmaceuticals and no specific paper, and labeling requirements?

a)

Excepted packaging

b)

Type A packaging

c)

Type B packaging

74.

Which of the following packaging is used to transport very small quantity of radiopharmaceuticals and has a high potential for radiological hazard for the person who accepts the package, must pass testing and standards of a package ?

a)

Excepted packaging

b)

Type A packaging

c)

Type B packaging

75.

Which of the following packaging is used to transport larger quantities of radio isotopes and it must be authorized by DOT and nuclear regulatory commission.

a)

Excepted packagin

b)

Type A packaging

c)

Type B packaging

76.

Upon completion of test, which of the following must meet with a SAR (Safety Analysis Report), reviews, issues and compliance?

a)

Excepted packaging

b)

Type A packaging

c)

Type B packaging

77.

Which of the following are used in myocardial blood flow? Select all that apply

a)

(N) Ammonia

b)

(O) Water

c)

(Rb) Rb

d)

(O) Carbon monoxide

e)

(F) Fluorodeoxyglucose

78.

What of the following IS NOT one of the products of beta minus decay?

a)

Proton

b)

Electron

c)

Antineutrino

d)

Neutron

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