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BIOTECHNOLOGY: PRINCIPAL AND PROCESSES

Total questions: 20

Worksheet time: 10mins

Name
Class
Date
1.

MOLECULAR SCISSORS USED IN GENETIC ENGINEERING IS-

a)

DNA LIGASE

b)

DNA POLYMERASE

c)

HELICASE

d)

RESTRICTION ENDONUCLEASE

2.

Construction of a recombinant DNA involves

a)

Cleaving and rejoining DNA SEGMENT with ligase alone

b)

Cleaving DNA segment with ligase and joining them with endonuclease

c)

Cleaving DNA segment with endonuclease and joining them with ligase

d)

cleaving and rejoining DNA segment with endonuclease alone

3.

Which is used extensively for genetic engineering in plants?

a)

Agrobacterium tumefaciens

b)

Xanthomonas citri

c)

Bacillus coagulens

d)

Clostridium septicum

4.

Restriction endonucleases cut

a)

single stranded DNA

b)

single stranded RNA

c)

Double stranded DNA

d)

Double stranded RNA

5.

The enzymes which are commonly used in genetic engineering are

a)

Restriction endonuclease and polymerase

b)

Endonuclease and ligase

c)

Restriction endonuclease and ligase

d)

Ligase and polymerase

6.

Identify the plasmid

a)

EcoRI

b)

pBR322

c)

AIUI

d)

Hind II

7.

Ti- Plasmid is obtained from

a)

Azotobacter

b)

Agrobacterium

c)

Yeast

d)

Rhizobium

8.

PCR is required for

a)

DNA synthesis

b)

DNA amplification

c)

Protein synthesis

d)

Amino Acid synthesis

9.

DNA fragments are joined by

a)

Ligase

b)

polymerase

c)

Helicase

d)

Gyrase

10.

Who discovered recombinant DNA technology

a)

Hargobind Khorana

b)

James D. Whatson

c)

S. Cohen and H. Boyer

d)

Sutton and Avery

11.

Which sequence can act as a restriction site

a)

AACCGG

TTGGCC

b)

GGTTGG

CCAACC

c)

AAGGCT

TTCCGA

d)

CTGCAG

GACGTC

12.

GAATTC IS RECOGNITION site for restriction endonuclease

a)

Hind III

b)

EcoR I

c)

Bam I

d)

Hae III

13.

Satellite DNA is useful tool in

a)

sex determination

b)

forensic science

c)

genetic engineering

d)

organ transplantation

14.

Agarose extracted from sea weeds finds use in

a)

PCR

b)

Gel electrophoresis

c)

Spectrophotometry

d)

Tissue culture

15.

Which one of the following techniques made it possible to genetically engineer living organisms

a)

Heavier isotope labelling

b)

Hybridization

c)

Recombination DNA techniques

d)

X-ray diffraction

16.

The process of separation and purification of expressed protein before marketing is called

a)

Upstream processing

b)

Downstream processing

c)

Bio-processing

d)

Post -production processing

17.

Biolistic is suitable for

a)

Transformation of plant cell

b)

DNA fingerprinting

c)

Disarming pathogen vectors

d)

Constructing recombinant DNA by joining with vectors

18.

In pBR 322vector of E.coli which option correctly identifies its components

a)

ori- original restriction enzyme

b)

rop-Reduced osmotic pressure

c)

Hind III, EcoR i - selectable markers

d)

ampR, tetR - Antibiotic resistance genes

19.

Restriction endonuclease

a)

Break DNA at specific sites

b)

Create sticky ends

c)

Produce cross-overs

d)

Both A and B

20.

Who among the following was awarded the Nobel Prize for the development of PCR technique?

a)

Herbert Boyer

b)

Hargovind Khorana

c)

Kary Mullis

d)

Arthur Kornberg