WorksheetsPEDIA IMMUNO PART 2
Total questions: 26
Worksheet time: 13mins
Life threatening, often fatal condition of graft vs host disease is graded as:
Grade IV
Grade V
Grade VI
Grade VII
The ff. are causes of graft failure, except:
transplant of an inadequate stem cell dose
viral infections with cytomegalovirus (CMV)
Infection with HHV6
immunologically mediated rejection of the graft by residual donor-type T cells
The ff. are true of anaphylaxis, except:
a serious allergic reaction that is rapid in onset and may cause death
Occurs due to sudden release of potentially biologically active mediators from mast cells and basophils
None of the above
Most common cause in community setting is food allergy
Clinical criteria involves the ff. systemic manifestation, except:
Integumentary - urticaria
Respiratory - bronchospasm and stridor
Cardiovascular - increased BP
Gastrointestinal - persistent crampy abdominal pain
None of the above
What is the most important treatment of anaphylaxis?
Immediate intubation to secure airway
Administration of epinephrine 0.3 to 0.5 mg, then after 5-15 minutes, as needed
Hook and infuse 0.9% NSS
Prednisone 10mg tablet OD
This condition is associated with dysmorphogenesis of the 3rd and 4th pharyngeal pouches during early embryogenesis
DiGeorge Syndrome
Down's Syndrome
Plummer-Vinson Syndrome
Sjogren's Syndrome
The hallmark of this disease is generation of autoantibodies directed against self-antigens, particularly nucleic acids
SLE
Systemic Onset Disease Juvenile Idiopathic Arthritis (SoJIA)
DiGeorge Syndrome
Sjogren's Syndrome
Oligoarthritis in juvenile arthritis is defined as:
< or = 4 joints within the first 6 months of disease onset
< or = 4 joints after the first 6 months of disease onset
<4 joints within the first 6 months of disease onset
>4 but <6 joints within the first 6 months of disease onset
Salmon colored lesions is classic for this condtion.
Systemic onset disease Juvenile idiopathic arthritis
Sjogren's Syndrome
SLE
DiGeogre Syndrome
The "juvenile" in juvenile idiopathic osteoarthritis is characterized with what age cut off?
<16 years old
<18 years old
<21 years old
<15 years old
The broad classification of symptoms of DiGeorge syndrome include the ff., except:
Abnormal facies
Thymic hypoplasia
Cleft palate
Hypercalcemia
The ff are risk factors of SLE, except:
Estrogen
EBV infection
Increase in HLA -B8, DR2 and DR3
None of the above
The ff are known to cause drug induced lupus like reactions, except:
Hydralazine
Isoniazid
Procainamide
Phenytoin
This is the mainstay treatment for significant manifestations of SLE
Hydroxychloroquine
NSAIDS
Corticosteroids
Methotrexate
Neonatal lupus is a result of transfer of what immunoglobulin from the mother?
IgE
IgA
IgG
IgM
This is the immunogenic portion of the HIV envelope glycoprotein that is used to detect HIV-1 antibodies in diagnostic assays.
gp41
gp120
gp160
gp56
This is the chemokine receptor that facilitates HIV entry into macrophages
CCR-5
CXCR-4
Gp41
Gp120
Which of the ff. has the least chance to contract HIV?
Sexual contact with an asymptomatic HIV+ human
Blood transfusion from an HIV+ donor
Intrapartum transmission to the baby due to mucosal exposure to HIV+ maternal blood and cervicovaginal secretions
Breastfeeding with HIV infected mothers
First cells to be infected if mucosa serves as the portal of entry.
Epithelial cells
Dendritic cells
Tissue Macrophage
Mast cells
CDC staging for children is based on what parameter?
CD4+ T cell count
CD8+ T cell count
HIV DNA count
Clinical symptoms
All are common opportunistic infection in pediatric population, except:
Pneumocystis jiroveci
Mycobacterium avium-intracellulare complex
Candida albicans
Giardia lamblia
Which of the ff statements is true?
HIV DNA PCR is the preferred test to diagnose all HIV-1 subtypes in infants and children <18mos of age
HIV RNA PCR is the prefered test to identify non-B subtype HIV-1 infections
HIV culture is recommended , but requires 4 weeks to do the test
HIV RNA PCR can have false positives in non-B subtype HIV-1 infections
Which of the ff is false regarding therapies for HIV
NRTIs are similar structure to building blocks of RNA
NNRTIs include efavirenz, etavirine and rilpivirine
Protease inhibitors bind where long viral polypeptides are cut to produce infectious virions, effectively making products, non-functional
Fusion inhibitors bind to gp41
Which of the ff. is false regardinng treatment for HIV?
CCR-5 antagonist blocks fusion to CD4+ cells
Integrase inhibitors such as raltegravir block the enzyme that catalyzes the incorporation of viral genome to host DNA
NRTIs are similar structures to building blocks of DNA
NNRTIs attach to reverse transcriptase and increase its motility, disrupting the activity of the enzyme
A 7 year old boy found to be HIV+ had a CD4+ count of 325 cells/ uL. What stage is he under, based on Age specific CD4+ T cell lymphocyte count?
Stage 1
Stage 2
Stage 3
Stage 4
Among the pediatric vaccines, which of the ff should not be given to HIV+ patients?
OPV
HepaB
Pneumococcal
DPT
