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frameshift mutation

Total questions: 16

Worksheet time: 21mins

Name
Class
Date
1.

Which type of mutation occurs when there is an addition or removal of a base?

a)

missense mutation

b)

nonsense mutation

c)

frameshift mutation

d)

point mutation

2.

What type of mutation is shown in the diagram?

a)

Point mutation - missense

b)

Frameshift Mutation - deletion

c)

Frameshift Mutation - addition

d)

Point mutation - nonsense

3.

A type of mutation that affect every codon beyond the point of mutation.

a)

Point Mutation

b)

Silent Mutation

c)

Nonsense Mutation

d)

Frameshift Mutation

4.

TRUE or FALSE. The removal of one base to the DNA sequence might lead to a change on the succeeding (next) codon.

a)

True

b)

False

5.
What type of gene mutation has occurred here? 
T-G-A-C-C-A
T-G-A-C-C-A-A
a)
Base Substitution
b)
Base Deletion
c)
Base Insertion
d)
Frameshift 
6.
What type of gene mutation has occurred here? Normal-
AGA-TTC-ATA-GCG
Mutant-
AGA-TTC-AAT-AGC-G
a)
deletion frameshift
b)
insertion frameshift
c)
substitution
d)
nonsense
7.
What type of chromosomal mutation has occurred?
a)
substitution
b)
insertion
c)
deletion
d)
nondisjunction
8.
DNA molecule segment is : TTACGCAAG
The mutated DNA segment is TTCGCAAG. This is an example of ___ mutation.
a)
Substitution
b)
Deletion
c)
Insertion
d)
Inversion
9.
ATTTGAGCC- Original
ATTGAGCC - Mutated
The example above is an example of a 
a)
Insertion- Frameshift
b)
Deletion- Substitution
c)
Deletion -Frameshift
d)
All of the above
10.
Why are insertion and deletion (frameshift) mutations so harmful?
a)
They change all of the codons from the mutation on down the line, which changes the amino acid sequence
b)
They insert things that an organism doesn't need.
c)
They often delete things that organisms need.
d)
Insertion and deletions are not any more harmful than substitution mutations.
11.
Identify the DELETION mutation form the following: 
ATG CCA AAT
a)
ATG TCA AAT
b)
ATG CCT AAA T
c)
ATC CA  AT
d)
ATG CCA AAT
12.
A segment of DNA produces methionine, threonine, histidine, aspartate, and glycine when translated. A substitution mutation occurs and causes the sythesis of the segment shown. Which is the new peptide chain when the new DNA segment is translated?
a)
methionine, leucine, histidine, aspartate, glycine
b)
methionine, phenylalanine, histidine, aspartate, glycine
c)
Methionine, proline, histidine, aspartate, glycine
d)
methionine, serine, histidine, aspartate, glycine
13.

ATT-TGA-GCC- Original

ATT-GAG-CC - Mutated

The example above is an example of a

a)

Insertion- Frameshift

b)

Deletion- Substitution

c)

Deletion -Frameshift

d)

All of the above

14.

Original DNA: CAT GAT CCA

New DNA: CAT TGA TCC A

What mutation occurred?

a)

deletion

b)

substitution

c)

tranverse

d)

insertion

15.
Original: ATC CAT
Mutation: ATC GCAT
What mutation occurred?
a)
deletion
b)
insertion
c)
silent
d)
transverse
16.

What type of gene mutation has occurred here? Normal-

AGA-TTC-ATA-GCG

Mutant-

AGA-TTC-AAT-AGC-G

a)

deletion frameshift

b)

insertion frameshift

c)

substitution

d)

nonsense