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Screening and diagnostic tests during pregnancy

Total questions: 20

Worksheet time: 20mins

Name
Class
Date
1.

Prenatal genetic testa are imperative for ___? Select all that apply.

a)

Women older than 35 years.

b)

Expecting mothers who have a familial history of chromosomal disorders and other birth defects.

c)

young women between 18-30 ears with a healthy reproductive history and no familial history of chromosomal disorders or birth defects.

2.

The purpose of genetic testing during pregnancy is ______?

a)

To rule out that the mother is at risk for genetic disorders

b)

To assess if the fetus is at risk for genetic disorders

c)

To assess if the mother is likely to develop gestational diabetes

3.

Aneuploidy is a term analogous to _____?

a)

Monosomy or loss of a chromosome

b)

Trisomy or gain of an extra chromosome

c)

can be determined using screening and diagnostic tests

d)

All the above is true.

4.

Blood tests done during the first trimester of pregnancy help identify _______? Select all that apply.

a)

Sexually transmitted disease such s syphilis and HIV

b)

Check for immunity to Rubella

c)

Identify Blood type and Rh factor

d)

Screen for anemia

e)

Check for Hepatitis B

5.

This test measure the thickness of space at the back of neck of the fetus and volume of fluid?

a)

Amniocentesis

b)

Chorionic Villus Sampling

c)

NT ultrasound

d)

None of the above is accurate

6.

This test can be done starting at 10 weeks of pregnancy. It takes about 1 week to get the results. DNA released from the placenta into the blood stream is tested to screen aneuploidy and problems with sex chromosomes.

a)

Amniocentesis

b)

Chorionic Villus Sampling

c)

Cell Free DNA test

d)

Ultrasound

7.

A screening test that shows that there is a problem when in actuality there is no problem is known as a _________.

a)

False Negative

b)

Negative

c)

Positive

d)

False Positive

8.

This invasive procedure requires the extraction of fluid from the amniotic sac of the mother.

a)

Chorionic Villus Sampling

b)

Amniocentesis

9.

This genetic condition causes serious problems involving the heart and brain, cleft lip and palate, and extra fingers and toes.

a)

Trisomy 21

b)

Trisomy 18

c)

Patau's Syndrome

d)

Turner's Syndrome

10.

A genetic disorder linked to serious problems including a small head, heart defects and deafness is ____.

a)

Down's syndrome

b)

Edward's Syndrome

c)

Pataus's Syndrome

d)

William's Syndrome

11.

The quad tests examines the blood for which of the following? Select all that apply.

a)

Alfa Fetal protein

b)

Human Chorionic Gonadotropin hormone

c)

Estriol

d)

Inhibin-A

12.

In this human chromosomal variation which affects the 21st chromosome, an extra copy of the 21st chromosome adheres to another chromosome. It is the rarest form of trisomies and the only inherited type.

a)

Mosaic Down's syndrome

b)

Trisomy 21

c)

Translocation

d)

Deletion

13.

Which of the following will result in your doctor requiring continued monitoring and specific tests? Select all that apply.

a)

History of diabetes in the family

b)

Baby not growing

c)

Less active baby

d)

Low amniotic fluid index

e)

History of prior still births

14.

The purpose of invasive prenatal testing is to make reproductive decisions such as ___________? Select all that apply.

a)

Continuation of pregnancy

b)

Timely Medical or surgical intervention in utero or immediately post birth

c)

Birthing Decisions

d)

Determining place of delivery

15.

Key issues that surround Non invasive Prenatal Screening include? Select all that apply

a)

Is the information being sought medically useful?

b)

Do these test undermine the future person’s ability to make their own choices about accessing and allowing others access to information that relates to their health, abilities, personality or physical attributes.

c)

Would these tests encourage discrimination against people with certain genetic features, including sex, or create damaging perceptions of what constitutes a ‘normal’ or ‘healthy’ baby.

d)

Testing for conditions where the accuracy of the test is unknown or poor raising anxiety for women and couples and may increase the number of women seeking invasive diagnostic testing.

16.

Estriol level which can be detected from urine sample or blood sample is critical information because ____? Select all that apply.

a)

Low estriol levels are indicative of congenital abnormalities in the developing fetus.

b)

Low estriol levels are indicative of chromosomal disorders in the developing fetus.

c)

Very high or elevated levels are linked to breast cancer in women.

d)

High levels of estriol is indicative of early puberty in developing girls.

17.

A 40 year old pregnant mother was found to have elevated levels of AFP. This is of great concern because ____? Select all that apply?

a)

Spina Bifida

b)

Defects of the esophagus

c)

Failure for the baby's abdomen to close

d)

Anencephaly

18.

Maternal serum sample is screened for AFP, hCG, Estriol and Inhibin A between __________

a)

2-3 weeks

b)

15-8 weeks

c)

15-21 weeks

d)

15-30 weeks

19.

The first protein marker associated with fetal abnormalities and Down's syndrome is _____?

a)

Estriol

b)

Inhibin-A

c)

AFP

d)

hCG

20.

Low levels of MSAFP (Maternal serum Alfa Fetal protein, Estriol, hCG is indicative of ______________ ?

a)

Patau's Syndrome

b)

Edward's Syndrome

c)

Down's syndrome

d)

William's Syndrome