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Mutations, Human Genetics, and Pedigree Charts! Oh My!

Total questions: 41

Worksheet time: 2hrs 3mins

Name
Class
Date
1.

Colorblindness is more common in males because it is controlled by

a)

Mendelian inheritance.

b)

Incomplete dominance.

c)

codominance.

d)

Sex-linked inheritance.

2.

This pedigree shows a trait that is most likely

a)

autosomal dominant.

b)

sex-linked.

c)

autosomal recessive.

3.

The mom in generation 1

a)

has the disorder.

b)

is homozygous for the trait.

c)

is a carrier.

4.

Which combination of sex chromosomes results in a male?

a)

XX

b)

YY

c)

XY

5.

A chart that tracks a disorder in a family is called a

a)

pedigree.

b)

Punnett Square.

6.

Generation 2 individual 3 is

a)

male.

b)

female.

7.

What genetic disease is the only one we studied that is caused by a dominant allele?

a)

PKU

b)

Cystic Fibrosis

c)

Huntington's Disease

d)

Tay Sachs Disease

8.
What do half colored symbols represent?
a)
The individual is a carrier.
b)
The individual expresses the trait.
c)
The individual has both recessive alleles.
d)
The individual has both dominant alleles.
9.

Chromosome that is not a sex chromosome

a)

Chromosome

b)

Autosome

c)

Sex Chromosome

d)

Homologous pair

10.
In the second generation-how many people have the disease or display the physical trait?
a)
2
b)
4
c)
5
d)
6
11.

If a gene is found only on the X chromosome and not the Y chromosome, it is said to be what?

a)

sex-linked trait

b)

polygenic trait

c)

codominant trait

d)

incomplete dominance trait

12.

In humans, the 23rd pair of chromosomes are called:

a)

Autosomes

b)

Sex chromosomes

c)

Chromatids

d)

Gender chromosomes

13.

What chromosomal disorder is displayed by this karyotype?

a)

Turner (XO) Syndrome

b)

Down Syndrome

c)

Trisomy 18

d)

Klinefelter's (XXY) Syndrome

14.

What chromosomal disorder is displayed by this karyotype?

a)

Turner (XO) Syndrome

b)

Down Syndrome

c)

Trisomy 18

d)

Klinefelter's (XXY) Syndrome

15.

An image that displays homologous chromosomes within a nucleus is called a:

a)

Pedigree

b)

Karyotype

c)

Family Tree

d)

Cladogram

16.

In this human karyotype, is the individual male or female?

a)

Male

b)

Female

17.

What 2 factors can a karyotype tell you?

a)

Gender

b)

Gene mutations

c)

Phenotype (physical appearance)

d)

Presence of chromosomal disorders

18.

If primarily males are affected, such as in the above pedigree, the trait is:

a)

Autosomal

b)

Sex-linked

c)

Dominant

d)

Recessive

19.
ATTTGAGCC- Original
ATTGAGCC - Mutated
The example above is an example of a 
a)
Insertion- Frameshift
b)
Deletion- Substitution
c)
Deletion -Frameshift
d)
All of the above
20.
Would a mutation in the DNA of a skin cell be passed on to an organism's offspring?
a)
Yes, because any change to the DNA is passed on to the offspring
b)
Maybe. Sex cells only use half of the body's genetic code. It might get the copy of a gene that wasn't mutated.
c)
No. Only mutations that occur in the gametes (sex cells) are passed on to the offspring
d)
Without knowing the animal, it would be hard to tell whether or not the mutation would be passed on.
21.
RNA is read in sections called:
a)
Triplets
b)
Genes
c)
Codons
d)
Genes
22.

A _____ mutation will most likely cause the biggest impact at the ______ of a gene sequence.

a)

substitution, end

b)

insertion, end

c)

substitution, beginning

d)

insertion, beginning

23.

A mutation that involves one or a few nucleotides is called

a)

a mutagen

b)

an inversion

c)

a point mutation

d)

a translocation

24.

Which of the following is a chromosomal mutation?

a)

inversion

b)

insertion

c)

point mutation

d)

substitution

25.

When a chromosome undergoes a deletion mutation, information is

a)

repeated

b)

lost

c)

copied

d)

transferred

26.

Most mutations

a)

have no effect on an organism

b)

are fatal to an organism

c)

are helpful to an organism

d)

are harmful to an organism

27.

What are some characteristics of polyploidy plants?

a)

They tend to be weaker and smaller than diploid plants.

b)

They tend to be bigger and stronger than diploid plants.

c)

They tend to be weaker, but bigger than diploid plants.

d)

They tend to be smaller, but stronger than diploid plants.

28.

Sex-linked genes are located on

a)

the autosomal chromosomes.

b)

the Z chromosome only.

c)

the Y chromosome only.

d)

both the X chromosome and the Y chromosome.

29.

Colorblindness is more common in males than in females because the allele for colorblindness is

a)

dominant and located on the X chromosome.

b)

recessive and located on the Y chromosome.

c)

recessive and located on the X chromosome.

d)

recessive and located on the Y chromosome.

30.

Human males have

a)

one X chromosome only.

b)

two X chromosomes.

c)

one X and one Y chromosome.

d)

two Y chromosomes.

31.

Which of the following form(s) a Barr body?

a)

one of the Y chromosomes in a male cell

b)

one of the X chromosomes in a male cell

c)

one of the X chromosomes in a female cell

d)

both of the X chromosomes in a female cell

32.

Which of the following is caused by a dominant allele?

a)

Huntington’s disease

b)

colorblindness

c)

cystic fibrosis

d)

sickle-cell disease

33.

Which of the following diseases and conditions does not appear until late in a person’s life and causes mental breakdowns and loss of bodily control?

a)

cystic fibrosis

b)

sickle cell disease

c)

colorblindness

d)

Huntington disease

34.

Sickle cell disease is caused by a

a)

change in one allele.

b)

change in the size of a chromosome.

c)

change in two protons.

d)

change in the number of chromosomes in a cell.

35.

The failure of chromosomes to separate during meiosis is called

a)

nondisjunction.

b)

X-chromosome inactivation.

c)

Turner’s syndrome.

d)

Down syndrome.

36.

Which of the following combinations of sex chromosomes represents a female?

a)

XY

b)

XXY

c)

XXXY

d)

XX

37.

Which of the following can be used to cut DNA so it can be studied?

a)

restriction enzymes

b)

gel electrophoresis

c)

karyotypes

d)

haplotypes

38.

The Human Genome Project was an attempt to

a)

sequence every person’s DNA.

b)

sequence the DNA of every human gene.

c)

cure infectious human diseases.

d)

identify all restriction enzymes.

39.

Why are all X-linked alleles expressed in males, even if they are recessive?

a)

Males on have one X chromosome, and another X chromosome.

b)

Males only have one X chromosome and no chance for a dominant allele to block it.

c)

Males have an extra X chromosome that makes them easier to get genetic disorders.

d)

Women are cruel and love to see men suffer. Hahaha

40.

How might karyotypes be useful to medical doctors?

a)

They can count the number of genes it takes to create an elephant.

b)

They can check the results to see if there are any possible abnormalities or disorders found in the chromosomes.

c)

They can look for start and stop codons.

d)

The can see point mutations.

41.

Why do some kinds of point mutations generally result in greater changes (and possibly more damage) in proteins than others?

a)

Most point mutations do nothing

b)

Most point mutations cause harm no matter what the change might be in the protein.

c)

Many change proteins to become beneficial in the adult organism.

d)

Frameshift mutations, like insertions and deletions, can change the “reading frame” and mess up everything that comes after them. Others may do nothing or something minor.