The growth factor that is produced in the kidney and induces growth and differentiation of committed megakaryocyte progenitors is:

What platelet organelle sequesters ionic calcium and binds a series of enzymes of the eicosanoid pathway?

What platelet membrane receptor binds fibrinogen and

supports platelet aggregation?

What platelet membrane phospholipid flips from the inner

surface to the plasma surface on activation and serves as the assembly point for coagulation factors?

What is the name of the eicosanoid metabolite produced from endothelial cells that suppresses platelet activity?

Which of the following molecules is stored in platelet dense granules?

What plasma protein is essential to platelet adhesion?

Reticulated platelets can be enumerated in peripheral blood to detect:

Platelet adhesion refers to platelets:

What intimal cell synthesizes and stores VWF?

What subendothelial structural protein triggers coagulation through activation of factor VII?

What coagulation plasma protein should be assayed when platelets fail to aggregate properly?

What role does vitamin K play for the prothrombin group

factors?

What is the source of fibrinopeptides A and B?

What serine protease forms a complex with factor VIIIa, and what is the substrate of this complex?

What protein secreted by endothelial cells activates fibrinolysis?

What two regulatory proteins form a complex that digests activated factors V and VIII?

Coagulation factor VIII circulates bound to:

Most coagulation factors are synthesized in:

Iron is transported in plasma via:

What is the major metabolically available storage form of iron in the body?

The total iron-binding capacity (TIBC) of the serum is an indirect measure of which iron-related protein?

For a patient with classic iron study values that are equivocal for iron deficiency, which of the following tests would be most helpful in determining whether iron deficiency is present or not?

What membrane-associated protein in enterocytes transports iron from the intestinal lumen into the enterocyte?

Iron is transported out of macrophages, hepatocytes, and enterocytes by what membrane protein?

Below are several of the many steps in the process from absorption and transport of iron to incorporation into heme. Place them in proper order.

i) Transferrin picks up ferric iron.

ii) Iron is transferred to the mitochondria.

iii) DMT1 transports ferrous iron into the enterocyte.

iv) Ferroportin transports iron from enterocyte to plasma.

v) The transferrin receptor transports iron into the cell.

What is the fate of the transferrin receptor when it has completed its role in the delivery of iron to a cell?

The transfer of iron from the enterocyte into the plasma is REGULATED by:

Into which quadrant of a Thomas plot would a patient’s results fall with the following test results:

Soluble transferrin receptor: increased above reference interval Ferritin: decreased below reference interval

Hemoglobin content of reticulocytes: within the reference interval

A physician is concerned that a patient is developing iron deficiency from chronic intestinal bleeding due to aspirin use for rheumatoid arthritis. The iron studies on the patient show the following results above. How would these results be interpreted?

During the second trimester of fetal development, the primary site of blood cell production is the:

The best source of active bone marrow from a 20-year-old would be:

Which one of the following morphologic changes occurs during normal blood cell maturation:

Which one of the following cells is a product of the CLP?

Which one of the following cytokines is required very early

in the differentiation of a hematopoietic stem cell?

When a patient has severe anemia and the bone marrow is unable to effectively produce red blood cells to meet the increased demand, one of the body’s responses is:

Hematopoietic stem cells produce all lineages of blood cells in sufficient quantities over the lifetime of an individual because they: