Font size
WorksheetsBiopharmaceutics & Pharmacokinetics
Total questions: 19
Worksheet time: 22mins
Alpha-1-glycoprotein binds with:
acidic, highly lipophilic drugs
acidic, highly lipophobic drugs
basic, highly lipophilic drugs
basic, highly lipophobic drugs
All phenomenon characteristics are associated with the process of facilitated diffusion of drugs, except:
the drug crosses the membrane against a concentration
the process is selective for certain ionic or structural configuration of the drug
if two compounds are transported by the same mechanism
the transport mechanism becomes saturated at high drug solubility
As the polarity of drug increases due to the presence of hydrophilic functional groups, water solubility:
increases
decreases
no change
polarity is not related to
The bioavailability or bioequivalence problems may depend on the following except:
manufacturing method employed
change in manufacturing practice
environment
complex
blood flow
Which of the ff. can be considered as less perfused organ?
skin
fat tissue
kidneys
lungs
Chief cells is to pepsin, while parietal cells is to:
mucous
serious secretions
cholecystikinin
zymogen
HCl
Phase I drug study poses a problem which should be considered from the following except:
safety
analytic sensitivity
pharmacodynamics
pharmacokinetics
The partition coefficient can be considered as:
an index of the relative affinity of a drug for two immiscible solvents
an index of comparative solubilities in solvents
a parameter of the relative rate of partitioning from one phase into another
all of the above
Which of the ff. correct?
reduced binding to protein by the drug molecule will decrease the therapeutic effect of the drug
saturation of binding produces linear pharmacokinetics
bound drugs can diffuse into the tissues
only the unbound drug may be available for metabolism
Metabolites can have the ff. properties except:
produce therapeutic activity
cannot produce toxicity
can be reactivated
can be in its inactive form
Chemical variation:
a. change the structure of the pharmaceutic ingredient to increase the pharmacologic response
b. change the structure of the active ingredient to increase pharmacologic
c. both a & b
d. none of the choices
Formation of pairs (for highly ionized compounds) with endogenous substrate present at the GIT to form neutral
complexes that are absorbed by passive diffusion
pinocytosis
convective transport
ion pair
facilitated transport
Factors affecting membrane transport, except:
pKa
diffusivity
partition coefficient
presence or absence of a charge
surfactants
Used in calculating dose size for children based on age: (Multiple answers)
Young
Cowling
Clark
The lesser the gastric emptying time, the faster the gastric emptying rate.
true
false
erroneous
not valid
Venous blood is:
non- oxygenated blood
oxygenated blood
In drug metabolism, the following is true:
drug metabolism is often termed detoxification or detoxication
it refers solely to the chemical bio-transformation of a drug by the biological environment
both
none of the choices
If the drug appears in the feces after oral administration
the drug was not completely absorbed in the GIT
the drug was not completely dissolved in the GI fluids
the drug formed complex with other materials in the GIT
metabolites are excreted therefore, will not produce toxic effects on the individual
These are formed if a substance is capable of forming channels, or cages which can take up another substance
into the interspace of the structure:
metal complexation
coordination
ligand field
clathrate
chelate
