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WorksheetsPharma Knowledge
Total questions: 10
Worksheet time: 10mins
What is right definition of half-life of a drug?
The concentration of the drug in the body will be half of the starting dose
The concentration of the drug in the body will be 90% of the starting dose
The concentration of the drug in the body will be 10% of the starting dose
The concentration of the drug in the body will be full of the starting dose
What is the Shelf life of a drug?
Shelf life is defined as the time necessary for the drug to decay to 90% of its original concentration
Shelf life is defined as the time necessary for the drug to decay to 50% of its original concentration
Shelf life is defined as the time necessary for the drug to decay to 10% of its original concentration
Shelf life is defined as the time necessary for the drug to decay to 100% of its original concentration
What is Bioavailability?
The proportion of a drug which introduced into the body and so is able to have an active effect
The concentration of the drug in the body will be half of the starting dose
The proportion of a drug which introduced into the body and so is able to have an inactive effect
The proportion of a drug which introduced into the body and so is able to have an partially active effect
What is C-Max of a drug?
· The maximum concentration recorded
· The minimum concentration recorded
· The shelf life of a drug
· None of the above
What is T-max?
· The time take to reach Cmax.
· The time take to eliminate
· The time take to reach half life of a drug
· All of the above
What is Area Under Curve (AUC)?
· A measure of the exposure to the drug
· A graph plotted between Concentration and Time
· It describes the variation of a drug concentration in blood plasma as a function of time
· All are correct
How Bioequivalence determined?
· It determined by comparing the relative bioavailability of the research drug versus the generic drug
· It determined by comparing the relative bioavailability of the generic drug versus the generic drug
· It determined in healthy animals
· None is correct
What factors affect bioavailability?
· Absorption.
· Food Effect.
· Drug metabolism/ biotransformation
· All of the above are correct
Based on FDA, ASEAN and European medicine agency, Generic is Bioequivalent to innovator when AUC is in between
· 80%-125%
· 85%-125%
· 80%-120%
· 90%-100%
What is correct about elimination of drug?
Drug elimination is the removal of drugs from the body
Drug elimination is the absorption of drugs from the body
Drug elimination is the 50% eliminates of drugs from the body
Drug elimination is the metabolism of drugs from the body
