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WorksheetsMed Chem
Total questions: 10
Worksheet time: 8mins
What is meant by a binding site?
The area of a macromolecular target that is occupied by a drug when it binds.
The portion of the drug to which a drug target binds.
The functional groups used by a drug in binding to a drug target.
The bonds involved in binding a drug to its target.
Which of the following binding interactions is likely to be the most important initial interaction when a drug enters a binding site?
van der Waals interactions
hydrogen bond
ionic
induced dipole-dipole interactions
What secondary messenger is generated as a result of the action of nitrous oxide?
GTP
cyclic GMP
ATP
cyclic AMP
Which of the following is not a neurotransmitter?
acetylcholine
cyclic AMP
noradrenaline
dopamine
Which of the following is not a G-protein coupled receptor?
the muscarinic receptor
the glycine receptor
the adrenergic receptor
the glutamate receptor
Which of the following is a natural chemical messenger for the adrenergic receptor?
Acetylcholine
Serotonin
Dopamine
Noradrenaline
What is the predominant adrenoceptor in heart muscle?
β2-adrenoceptor
α2-adrenoceptor
β1-adrenoceptor
α1-adrenoceptor
To which class of compounds do adrenaline, noradrenaline and dopamine belong?
Phenethylamines
Catecholamines
Diphenolethylamines
Adrenergics
What is meant by a lead compound in medicinal chemistry?
A drug containing the element lead.
A leading drug in a particular area of medicine.
A compound that acts as the starting point for drug design and development.
A drug which is normally the first to be prescribed for a particular ailment.
Which of the following needs to be established before the search for a lead compound takes place?
the pharmacophore
Structure-activity relationships
a bioassay
patents
