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IRAT_ Diseases Of Placenta_TBL _ MDC209_ 27 April 2020

Total questions: 6

Worksheet time: 12mins

Name
Class
Date
1.

A 22-year-old woman , recently immigrated from Jakarta, Indonesia, is in the early second trimester of her pregnancy. She has noted a small amount of vaginal bleeding for the past week and has had marked nausea and vomiting for 3 weeks. On physical examination, the uterus measures large for dates. An ultrasound examination shows intrauterine contents with a “snowstorm appearance,” and no fetus is identified. The gross appearance of tissue obtained by dilation and curettage is shown in the figure. Which of the following would be the most likely diagnosis?

a)

Endometrial carcinoma

b)

Leiomyoma

c)

Hydatidiform mole

d)

Endometriosis

2.

A 24-year-old married woman has a spontaneous abortion at 15 weeks’ gestation. The male fetus is small for gestational age and is malformed, with syndactyly of the third and fourth digits of each hand. The placenta also is small, and shows 0.5-cm grapelike villi scattered among morphologically normal villi. Chromosomal analysis of placental tissue is most likely to show which of the following karyotypes?

a)

A. 45,X

b)

B. 46,XX

c)

C. 69,XXY

d)

D. 47, XXY

3.

A 24-year-old woman suddenly notices a bloody, brownish vaginal discharge. The next day she has shortness of breath. On physical examination, a 3-cm, red-brown mass is seen on the lateral wall of the vagina. A chest radiograph shows numerous 2- to 5-cm nodules in both lungs. Laboratory studies show that her serum human chorionic gonadotropin levels are markedly elevated. A biopsy specimen of the vaginal mass is obtained and shown in the figure. Which of the following would be the most likely diagnosis?

a)

Leiomyosarcoma

b)

Choriocarcinoma

c)

Endometrial carcinoma

d)

Carcinoma of cervix

4.

A 23year-old woman experiences sudden onset of severe lower abdominal pain. Physical examination shows no masses, but there is severe tenderness in the right lower quadrant. A pelvic examination shows no lesions of the cervix or vagina. Bowel sounds are detected. An abdominal ultrasound scan shows a 4-cm focal enlargement of the proximal right fallopian tube. A dilation and curettage procedure shows only decidua from the endometrial cavity. The representative gross pathologic specimen is shown here. Which of the following would be the most likely diagnosis for this patient?

a)

Ectopic pregnancy

b)

H mole

c)

Choriocarcinoma

d)

Yolk sac tumor

5.

A 33-year-old woman at 36-weeks of pregnancy presents to the emergency department for vaginal bleeding and back pain . She is chronic hypertensive and smoker. Ultrasound examination identifies a retroplacental hematoma. Physical exam shows bright red blood and a firm, tender uterus. Which of the following is the most likely diagnosis?

a)

Leiomyoma

b)

Choriocarcinoma

c)

Placental abruption

d)

Leiomyosarcoma

6.

A 36-year-old woman comes to the obstetric clinic for her first prenatal visit. She had a positive home pregnancy test 2 weeks ago. Her last menstrual period was 14 weeks ago. The fundal height measures 18 weeks and there is no fetal heartbeat noted. Ultrasound shows no definable fetal parts. Uterine contents exhibit snowstorm appearance on ultrasound. She also complains of vaginal bleeding and feeling of nausea. Past medical history shows she has dilatation and curettage for abnormal pregnancy that she was told looked like “ a bunch of grapes”. Representative gross lesion is shown here. Which of the following laboratory abnormalities do you expect to find in this patient?

a)

Increased serum beta human chorionic gonadotropin

b)

Increased serum CA-125

c)

Increased serum Inhibin

d)

Increased serum neuron specific enolase