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WorksheetsHepatitis (general)
Total questions: 19
Worksheet time: 10mins
Which of the following is/are true about Hepatitis A vaccine:
The vaccine may cause mild jaundice 2-6 weeks after
administration
It can be given to pregnant women when clinically indicated
Hepatitis A antibody levels should be tested to check for a response
Is only effective if given to unvaccinated contacts of Hepatitis A
within 72 hours of the onset of jaundice in the index case
Should not be given to someone who may already be incubating Hepatitis A infection
Which of the following is/are true:
All available monovalent Hepatitis A vaccines are licensed for
patients aged 12 years and above
There are paediatric Hepatitis A vaccines available which contain higher doses of antigen than the adult preparations
A booster dose of Hepatitis A vaccine should be given 6-12 months
after the first
If the Hepatitis A booster dose is delayed the course should be
restarted
A booster dose at 10 years is indicated for those at ongoing risk
Hepatitis A vaccine is routinely recommended for the following groups:
Food handlers working in a shellfish market
Individuals going to reside in Spain
Sewage workers
Patients with chronic renal disease
Injecting drug users
Human Normal Immunoglobulin (HNIG):
When being used as post-exposure prophylaxis for Hepatitis A may
protect against disease if given within 14 days of exposure
Live vaccines (except yellow fever vaccine) should preferably not be
given for 3 months after administration of HNIG
Can provide protection lasting up to 2-3 years
Should not be given to those with an allergy to eggs
The dose of HNIG for a child aged 5 years is 250 mg
Which of the following Hepatitis A vaccine products is/are
available:
Combined Hepatitis A and B vaccine
Combined Hepatitis A and C vaccine
Monovalent Hepatitis A vaccine
Combined Hepatitis A and typhoid vaccine
Combined Hepatitis A and cholera vaccine
Which of the following is/are true:
HNIG is routinely recommended for travel prophylaxis for Hepatitis A
HNIG is usually administered subcutaneously
If HNIG is given live vaccines should preferably not be given for 3 weeks
Hepatitis A vaccine should preferably be administered at least 2
weeks before travel departure
After a dose of monovalent Hepatitis vaccine Hepatitis A antibodies are generally detectable in all individuals at 7 days using current assays
Which of the following statements is/are true regarding Hepatitis B infection:
Infection results in jaundice in greater than 50% of all cases
The incubation period ranges from 14-60 days
Chronic disease is strongly linked to the development of liver cancer
Less that half of children infected per-natally develop chronic
disease
Most of those infected as adults will become chronic carriers of HBV
Hepatitis B vaccines:
Are not effective in patients with acute hepatitis B
Are live attenuated vaccines
Fewer than 10% of adults fail to respond to hep B vaccines
adequately
Are very effective if used for post-exposure prophylaxis
Work best in those aged over 40 years
Hepatitis B vaccines:
Contain hepatitis B core antigen prepared from yeast cells
All contain the same dosage
Should not be given to a person who may already have been
exposed to Hepatitis B without checking for markers of past
infection
Should not be administered into the buttock
Induce anti-HBs specific antibodies
Which of the following people should receive pre-exposure
Hepatitis B vaccine:
Healthcare workers (including students/trainees) working in the UK
Staff working in residential accommodation for people with learning difficulties
Embalmers
Prison officers
Laboratory staff handling materials which may contain the virus
Which of the following should receive pre-exposure Hepatitis B vaccine:
Short term foster carers
Sewage workers
People receiving regular blood transfusions
People with chronic liver disease
People with chronic renal disease
Which of the following should receive pre-exposure Hepatitis B vaccine:
People living in residential accommodation with learning disabilities
Prison inmates
Intra-venous drug users
Household contacts of people who inject drugs
People who work with primates
Post-exposure prophylaxis with HBIG is recommended for:
Non-responders to hep B vaccine who have had a needlestick injury from a patient with acute hepatitis B
People who have had unprotected sexual intercourse with a case of acute of hepatitis B seen within one week of last contact
Babies born to women with chronic hepatitis B infection who are e antigen positive
People who have had unprotected sexual intercourse with a
recently diagnosed case of chronic hepatitis B two weeks ago
Babies born to women who have developed acute hepatitis B
infection during pregnancy
Available pre-exposure hepatitis B immunisation schedules for high risk exposure in adults include:
0, 1 month, 2 months and 12 months
0, 7 days, 21 days and 12 months
0, 1 month, 6 months and 12 months
0, 2 months, 6 months and 12 months
0, 2 months, 3 months and 4 months
An immunocompetent healthcare worker is found to have an anti-HBs level of 10 – 100 mIU/ml after a course of hepatitis B vaccine. Which of the following is/are true?:
They need no further doses of hep B vaccine as satisfactory
protection has been achieved
They should have 1 further dose of hep B vaccine
They should have 1 further course of hep B vaccine
They should have single booster dose of hep B vaccine after 5
years
They should receive a booster dose of hep B vaccine every 5 years
The following is/are true of babies born to hep B positive mothers:
If the mother is HBsAg positive and HBeAg the baby should receive
a dose of HBIG at birth
If the mother is HBsAg positive, HBeAg negative and the baby
weighs 1800g the baby should receive HBIG
The first dose of hep B vaccine should be given within 24 hours of
birth
They should be tested for HBsAg at 6 months of age
They should be tested for HBsAg at 12 months of age
Babies born after the 1st August 2017 in the UK whose mothers are NOT known to be hep B carriers should receive:
Three doses of Hexavalent vaccine at 8, 12 and 16 weeks
A booster dose of Hexavalent vaccine at 1 year
A blood test for HBsAg at 1 year
A pre-school booster dose of Hexavalent vaccine
A blood test to measure response to the hep B vaccine 2 months after completion of the Hexavalent vaccine schedule
Babies born after 1st August 2017 in the UK to hep B carrier
mothers should receive:
Doses of monovalent hep B vaccine at birth and 4 weeks
Three doses of Hexavalent vaccine at 8, 12 and 16 weeks
A dose of Hexavalent vaccine at 1 year
A dose of monovalent hep B vaccine at 1 year
A pre-school booster dose of monovalent vaccine at 3 years 4
months
Which of the following should NOT be given Hepatitis B vaccine:
Those with a confirmed anaphylactic reaction to a previous dose of Hepatitis B vaccine
Immunosuppressed individuals
Pregnant women
HIV positive people
Premature infants
