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WorksheetsCAH-High Yield
Total questions: 26
Worksheet time: 19mins
Decreased aldosterone
11 beta hydroxylase
17 alpha hydroxylase
21 hydroxylase
Decreased cortisol
11 beta hydroxylase
17 alpha hydroxylase
21 hydroxylase
Increased mineralocorticoids
11 beta hydroxylase
17 alpha hydroxylase
21 hydroxylase
Increased glucocorticoids
11 beta hydroxylase
17 alpha hydroxylase
21 hydroxylase
Increased sex hormones
11 beta OH
17 alpha OH
21 OH
Decreased BP
11 beta OH
17 alpha OH
21 OH
Increased Na+
11 beta OH
17 alpha OH
21 OH
K+ wasting is seen in which of the following adrenal enzyme deficiencies?
11 beta OH
17 alpha OH
21 OH
Renin will be low in which of the following enzyme deficiencies?
11 beta OH
17 alpha OH
21 OH
Female with ambiguous genitalia and/or postnatal virilization...
11 beta OH
17 alpha OH
21 OH
Male with precocious puberty...
11 beta OH
17 alpha OH
21 OH
17 yo female with amenorrhea, scant pubic hair, and Tanner stage 2...
11 beta OH
17 alpha OH
21 OH
The gene for 21 OH enzyme is located on which chromosome?
(a)
4 week old boy brought to the PCP for vomiting. Mother notes poor feeding, crying inconsolably, vomits with each feed.
Physical exam reveals a baby with below-birth weight, BP 88/55, HR 180, sunken fontanel, tacky mucous membranes, poorly responsive infant with descended testes and capillary refill of 3-4 seconds.
11 beta OH
17 alpha OH
21 OH
12 yo boy presents to the clinic due to concerns from his mother that "he is growing too fast". Patient is at Tanner stage 4 and is showing male-pattern of hair growth on his body. His mom wants to know if he will be very tall in the future. What is the best answer to give her?
After running some labs I will have a better answer, but chances are he may be extremely tall.
After running some labs I will have a better answer, but chances are he may be shorter than average.
After running some labs I will have a better answer, but chances are he may be of average height.
After running some labs I will have a better answer, but chances are he may become more muscular.
Goal of CAH treatment
Correct cortisol deficiency if present
Correct aldosterone deficiency if present
Regulate androgens to support normal development
Regulate androgens to support psychological wellbeing
Adult males with 21 OH CAH are at risk for which of the following:
Acromegaly/gigantism
Testicular tumors
Infertility
Short adult stature
8 yo Hispanic girl presents for a wellness check-up. She has pubic hair, strong body odor for about 1 year, and mild acne. Neither the patient or mom are sure how long the pubic hair has been present. On her last exam 3 years ago she didn't have any. Mom says she's always been tall despite everyone in her family being relatively short. The rest of her PE is normal and her vitals and blood panels were non-contributory. What do you want to test for next?
11 beta hydroxylase deficiency
17 alpha hydroxylase deficiency
21 hydroxylase deficiency
Neonate signs of CAH
vomiting, diarrhea, hypoglycemia, dehydration, ambiguous genitalia, irritable, and poor feeding
hirsutism, elevated blood pressure, hydrops fetalis
hypertension, high-pitched cry, decreased muscle tone, hyperkalemia
anencephaly, flat-facies, slanted eyes and ears
Which of the option(s) below can be true of GIRLS with severe/full CAH enzyme deficiencies?
Ambiguous genitalia at birth (normal genitalia if mild CAH)
Clitoromegaly with embedded urethra
Precocious pubic, facial, and body hair later in childhood
Tall stature
High blood pressure
Which of the option(s) below can be true of BOYS with severe/full CAH enzyme deficiencies?
Ambiguous genitalia at birth (normal genitalia if mild CAH)
Tall stature
Precocious puberty and phallic enlargement
High blood pressure
Test to determine sex in a baby with ambiguous genitalia
Amniocentesis
Karyotyping
Western Blot
Genetic testing
Treatment for glucocorticoid deficiency in CAH
Life-long estrogen/progesterone combination
Life-long ketoconazole
Life-long hydrocortisone
Life-long chelating agent therapy
Treatment for mineralocorticoid deficiency in CAH
Life-long ketoconazole
Life-long hydrocortisone
Adrenal stimulation with OMM
Adjunct fludrocortisone acetate
Postnatal 21 OH CAH definite diagnosis is done by measuring what on a heel stick of a baby?
Elevated 17 OH progesterone
Elevated aromatase
Elevated DHT
Elevated testosterone, Leydig cells, and LH
Prenatal testing of CAH include:
Karyotyping
Amniocentesis
Genetic testing in mother
Chorionic villi sampling and amniocentesis
