WorksheetsGLUCOCORTICOIDS & MINERALOCORTICOIDS
Total questions: 15
Worksheet time: 30mins
At a certain blood concentration of cortisol when protection is seemingly achieved cortisol exerts (X) to the hypothalamic release of CRF
and the pituitary release of ACTH
(a)
TRUE regarding ACTH
ACTH is a 39 amino acid polypeptide
Secreted by the posterior pituitary
Structurally similar to leucocyte stimulating hormone
Its release from pituitary is mediated by CRH
(X) serves as a mediator of ACTH action within the cell
(a)
Side effects of ACTH use include:
acne
hyperkalemic acidosis
hypotension
heart failure
CORRECT pairings regarding interpretation of ACTH stimulation test
Addison's disease: Cortisol (LOW), ACTH (HIGH)
Addison's disease: Cortisol (LOW), ACTH (LOW)
Pituitary adenoma: Cortisol (LOW), ACTH (HIGH)
Pituitary adenoma: Cortisol (LOW), ACTH (LOW)
Prolonged corticosteroid use: Corticosteroid (LOW), ACTH (LOW)
Which of the following is TRUE regarding metabolic effects of glucocorticoids?
It decreases protein breakdown in muscle
Truncal adipocytes are more sensitive to cortisol
It inhibits peripheral utilization of glucose
It increases glycogen synthesis
Which of the following is TRUE regarding actions of mineralocorticoids on water & electrolyte balance?
It acts on distal tubules & collecting ducts of kidney
It enhances the secretion of Na+ from tubular fluid
Decreases the urinary excretion of K+
Has no effect on the urinary excretion H+
Regarding the diagram, name X & Y
X= corticosteroids, Y= NSAIDs
X=NSAIDs, Y=corticosteroids
X=corticosteroids, Y= opioids
X=opioids, Y=corticosteroids
TRUE regarding the dexamethasone suppression test:
X= Ectopic ACTH, Y= Cushing's Disease, Z= Adrenal Cushings
X=Adrenal Cushings, Y=Ectopic ACTH, Z= Cushing's Disease
X=Cushing's Disease, Y=Ectopic Cushings, Z=Adrenal Cushings
X=Cushing's Disease, Y=Adrenal Cushings, Z=Ectopic ACTH
What is the corticosteroid treatment for asthma crisis?
(a)
Contraindications to use of corticosteroids include:
Glaucoma
Osteoporosis
Peptic ulcer
Herpes Simplex
Which inhibitor of synthesis of adrenocortical steroids is a competitive inhibitor of conversion of pregnenolone to progesterone ?
MITOTANE
METYRAPONE
AMINOGLUTETHIMIDE
KETOCONAZOLE
TRILOSTANE
Examples of MINERALOCORTICOID RECEPTOR ANTAGONISTS include:
Prednisolone
Spironolactone
Eplerenone
Progesterone
TRUE regarding immunosuppresive effects of corticosteroids:
Antibodies production can be reduced by large doses of steroids
Used in autoimmune diseases eg., ITP, haemolytic anaemia
Increases antigen expression from grafted tissue
It has minimal effect on cellular immunity
TRUE regarding pharmacokinetics of corticosteroids
Not well absorbed when given orally
Corticosteroids bind to CBG (corticosteroids- binding globulin)
Metabolized in the liver
Excreted in the urine
