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WorksheetsPITUITARY HORMONES
Total questions: 10
Worksheet time: 20mins
TRUE regarding gonadotropins:
Menotropins are extract from urine of perimenopausal women
Follitrofin α (recombinant) has no LH activity
Lutropin is used in combination with follitropin α to stimulate follicular development in infertile woman with LH deficiency
Chorio-gonadotropin alpha (rhCG) is produced by the ovaries & extracted from urine
Examples of GnRH analougues
Goserelin
Triptorelin
Ganirelix
Abarelix
Leuprolide
Pulsatile release of GnRH analogues results in gonadal (X)
(a)
In delayed puberty, impaired response to IV or SC bolus of GnRH analogues is due to:
constitutional delay
hypogonadotropic hypogonadism
precocious puberty
Cushing's disease
TRUE regarding treatment with GnRH antagonists
Used to induce LH surge during controlled ovarian stimulation
Duration of administration is longer compared to non-pulsatile GnRH agonists
Require FSH supplement in follicular phase
Similar effects as continuous GnRH agonists
TRUE regarding Mecarsemin
It is a complex recombinant human IGF
For growth failure in children with severe IGF-1 deficiency, not responsive to rhGH
Route of administration is intravenous
Adverse effects include hyperglycemia
TRUE regarding Dopamine agonists
They act indirectly on pituitary dopamine receptors to inhibit prolactin release
D2 receptor agonists are ergot derivatives
It is used in treatment of pituitary deficiency
Examples include goserelin
TRUE regarding oxytocin use
Elicits milk ejection in lactating woman
Released during sexual orgasm
Control post partum hemorrhage
Augment dysfunctional labour
TRUE regarding vasopressin
Binds to V1- vasoconstriction
Binds to V2- diuresis
Desmopressin has more vasopressor effect than ADH
Used as treatment for nephrogenic diabetes insipidus
Clinical uses of growth hormone (other that GH deficiency)
Prader Willli syndrome
Marfan syndrome
Turner syndrome
Down syndrome
