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WorksheetsBASIC PHARMACODYNAMICS
Total questions: 10
Worksheet time: 20mins
The following assumptions are TRUE regarding dose-response relationship:
Rate of a chemical reaction is proportional to the concentrations of the reacting substances.
All receptors are identical & equally accessible to the drug.
The intensity of the response elicited by the drug is directly proportional to the number of receptors occupied by the drug .
The effective drug concentration does not change during the reaction.
TRUE regarding this dose-response curve
E = Effect observed at concentration C
Emax = Maximum response that can be produced by drug
EC50 = Concentration of drug that produces 50% maximum effect
This is a sigmoid log dose-response curve
(X) = The amount of drug needed to produce a certain response.
(a)
(X) = Maximum response that can be produced by the drug
(a)
(X) = The gap between the therapeutic effect & adverse effect denotes the safety margin or therapeutic index.
(a)
TRUE regarding Graded vs quantal response curve
Graded response curve is a response showing progressively increasing effect with increasing concentration of drug
Quantal response curve shows the all-or-none response
Example of graded response is death
Example of quantal response is blood pressure
TRUE regarding basic pharmacodynamics
Rightward position of a Drug Response Curve indicates higher potency.
Morphine is more efficacious than aspirin.
The therapeutic index is the % in which the dose effective in 99% of the population must be raised to cause toxicity /death in 1% of the population.
Warfarin has a large therapeutic index.
(X) = Smallest effective dose to produce stated effect in 50% of population
Clue: Abbreviation
(a)
(X) = Smallest effective dose to produce toxic dose in 50% of population
Clue: Abbreviation
(a)
(X) = Smallest effective dose to kill 50% of (animal) population
Clue: Abbreviation
(a)
