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Broad Spectrum Antibiotics

Total questions: 10

Worksheet time: 5mins

Name
Class
Date
1.

A 5-year-old female was brought to the emergency with fever, headache, confusion. A provisional diagnosis of bacterial meningitis was made. The child was known to be allergic to penicillin. She was admitted and IV antibiotics were started. A few days later, investigations revealed<br />Hb = 6 gm/dl, RBC count = 1.2 x 106 /mm3, Platelets 60000/ mm3, WBC count = 1500/ mm3.<br />Which of the following drugs is most likely to have caused the above findings?

a)

Gentamicin

b)

Doxycycline

c)

Vancomycin

d)

Chloramphenicol

2.

Chloramphenicol is drug of 2nd choice for empirical therapy in bacterial meningitis because

a)

It has wide Vd

b)

Concentration of drug in CSF is equal to that in plasma

c)

It has a broad spectrum of activity

d)

It has few side effects

3.

The following tetracycline is used in eradication of meningococcal carrier state

a)

Tetracycline

b)

Doxycycline

c)

Minocycline

d)

Demeclocycline

4.

Teratogenicity produced by tetracycline is

a)

Fanconi’s syndrome

b)

Discoloured deciduous teeth

c)

Impaired osteoid formation

d)

Diabetes insipidus

5.
A 23-year-old female, with 36 weeks of pregnancy, develops scrub typhus. She is prescribed T. Doxycycline. Which of the following statements is correct?
a)
The prescription is incorrect, as tetracyclines are teratogenic
b)
The prescription is correct, as tetracyclines are drug of choice for Rickettsial infections
c)
The prescription is correct, as tetracyclines can be given after 5 months of pregnancy
d)
The prescription is correct, as the benefit of saving life of mother is greater than risk of teratogenicity
6.

Doxycycline is drug of choice in all of the following conditions except

a)

Psittacosis

b)

Malaria

c)

Rickettsia

d)

Brucellosis

7.
All the following antibiotics can be used in Typhoid except
a)
Doxycycline
b)
Chloramphenicol
c)
Levofloxacin
d)
Ceftriaxone
8.

Which of the following statements regarding Chloramphenicol is false?

a)

Causes dose related myelosuppression

b)

Concentration of drug in CSF is equal to plasma

c)

Gray baby syndrome is a life-threatening side effect in infants due to incomplete drug acetylation

d)

Causes idiosyncratic aplastic anemia

9.

The following tetracycline causes vestibular toxicity

a)

Tetracycline

b)

Doxycycline

c)

Minocycline

d)

Demeclocycline

10.

The following tetracycline is used in leprosy

a)

Tetracycline

b)

Doxycycline

c)

Minocycline

d)

Demeclocycline