Worksheetscancer chemotherapy
Total questions: 9
Worksheet time: 5mins
Anticancer drug that is also used to treat psoriasis and rheumatoid arthritis:
Mercaptopurine (6-MP)
Methotrexate
Procarbazine
Alllopurinol
Combination of allopurinol with this anticancer drug can cause an increase in toxicity:
6-thioguanine
Flurouracil (5-fu)
6-mercaptopurine
Azatadine
Most common mechanism of resistance to both 6-MP (6-mercaptopurine) and 6-TG (6-thioguanine)
Increased levels of dihydrofolate reductase (dHFR)
Increased drug efflux from the cells by increased active transport
Decreased HGPRT activity
Decreased polyglutamate formation
Cellular mechanism(s) of resistance to the action of methotrexate:
Reduce drug transport
Increased polyglutamate formation
Increased levels of dihydrofolate reductase
A & c
This pyrimidine analog is used systemically to treat adenocarcinomas, topically for skin cancer and works through inhibition of DNA synthesis
Cytarabine (ara-c)
Vinblastine
Fluorouracil (5-fu)
Cladribine (leustatin)
Leucovorin "rescue"
Busulfan
Mercaptopurine
Methotrexate
Daunorubicin
A patient with fluorouracil-nonresponsive colon cancer is given this prodrug which following activation is a topoisomerase I inhibitor. Following administration, the patient experiences very severe diarrhea which causes hypovolemia. This drug probably was:
vincristine
irinotecan
paclitaxel
docetaxel
Anthracycline analog useful in treating acute myeloid leukemia; In combination with cytarabine (ARA-C), it can produce complete remissions in patients with acute myelogenous leukemia.
Plicamycin
Idarubicin
Bleomycin
Paclitaxel
Which is an antimetabolite ?
Cyclosporine
Methotrexate
Etoposide
Vinblastine
