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WorksheetsP6115 - METABa ang utak!
Total questions: 15
Worksheet time: 5mins
Which is a Phase I metabolism?
Sulfation
GSH Conjugation
Desulfuration
Methylation
T/F: PAPS is formed from inorganic sulfate and ATP.
True
False
T/F: Drug metabolism always results into inactive products ready for excretion.
True
False
Which statement is not true about the liver?
Most drugs will pass the liver because it is highly perfused with blood vessels.
The liver houses most of the metabolizing enzyme of the body.
The liver greatly affects the amount of drug available for distribution.
None of the above.
Which of the following is not a factor in drug metabolism?
Age
Gender
Religion
Dose frequency
Which CYP isozyme has the largest coverage of drugs that it metabolizes?
CYP 2D6
CYP 1A1
CYP 2E1
CYP 3A4
Grapefruit juice (GPJ) causes drug-food metabolic interactions with which of the following drugs?
Statins
Clopidogrel
Amiodarone
All of the above
A carbinolamine intermediate is common in which metabolic reaction?
Aromatic reduction
Oxidative dealkylation
Oxidative deamination
Methylation
Which amino acid is specifically used by birds for their metabolism?
Ornithine
Aspartate
Glycine
Histidine
Which of the following can be a target molecule for sulfate conjugation?
T4
Acetaminophen
Deoxycholic acid
All of the above
Which of the following is a target molecule for acetylation?
Hydroxychloroquine
Indapamine
Procainamide
Sulfonamide
Which of the following is more important in neurotransmitter synthesis than in metabolism?
Acetylation
GSH conjugation
Methylation
Hydrolysis
Which enzyme is responsible for the synthesis of Epinephrine from Norepinephrine?
COMT
PNMT
CYP 3A4
Acetyltrasnferase
Who are the fast acetylators?
Italians
French
Thai
Americans
T/F: Small drug molecules often pass thru the body unchanged.
True
False
