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WorksheetsPT716A_DAY3_55_pilot plant scale up for liquid dosage form
Total questions: 20
Worksheet time: 10mins
What are the requirements to scale up of simple solution
Tanks of adequate size
Suitable mixing capacity
Heating and cooling capabilities
In scale up technique, filtrations is required for
Removing impurities
Removing active or adjuvant ingredient
Removing undissolved materials
During scale up of liquid dosage form, all equipment must be made of
Suitable and non -reactive
Sanitary materials
Constructed to facilitate easy cleaning
In scale up technique, liquid pharmaceutical processing materials fabricated from -
(a)
What are the types of stainless steal that are used in the pharmaceutical industry for liquid scale up -
Type 308
Type 305
Type 316
During scaling up of simple solution , removing the surface alkalinity of stainless steal using an acid solution to prevent rust, is known as -
(a)
During scaling up technique, teflon and glass are used to minimize the interaction between solution and metallic surface
True
False
Preparation of suspension, equipment must be selected according to -
Size of the batch
Maximum viscosity of the product
Both
Before scaling up process, hydration of suspending agent depends on
Time
Temperature
Larger portion of vehicle
In scale up technique of suspension, air entrapment is occure that can be removed by using -
(a)
What are the parameters for processing an emulsion
Temperature
Homogenizing equipment
Filling equipment
Mixing equipment
During scale up technique, stability of emulsion depends on
Particle size distribution
Zeta potential
Both
Particle size of active ingredients
11-25 microns
10-25 microns
5-12 microns
What are the factors that are influences the suspension process -
Viscosity
Density
Particle size
Particle size distribution
What are the factors that are influences the emulsion preparation
Surface tension
Surfactants
Stabilizers
Manufacturing of suspension with high shear mixer form -
(a)
Disparsed phase of emulsion is made up of
Oil
Waxes
Both
What are the physical characteristics of API in suspension
Wet easily
Disparsed easily
Tend not to agglomerate
Unwanted particles are most efficiently removed by filtering the separate oil and water phases before emulsification
True
False
Emulsion is viscous in nature, so it requires pump.
True
False
