GLP1 mediates it’s effects via receptors belonging to.........these receptors are found in pancreatic islets and also various other tissues throughout the body including brain, kidney, liver

Incretin based therapies include

Semaglutide is a .....................GLP1 with ................. homology To native GLP1 hormone

GLP1 stands for

An optimal diabetes therapy would provide improved glycemic control with minimal risk of hypoglycaemia, improve beta cell function & target other associated pathological defects of T2DM such as ........... , ............ & ..............

GLP1 is a natural incretin hormone secreted by ................ in response to food intake

GLP1 stimulates insulin secretion & suppresses glucagon secretion but only when glucose levels are elevated thus protecting against hypoglycaemia

GLP1 delays stomach emptying and reduces appetite resulting in satiety (feeling of fullness) and contributing to weight loss

Native GLP1 has limited potential as a treatment for type 2 diabetes as it is rapidly degraded by enzyme ............ resulting in a half life of approx...............

GLP1 based therapies with .......... have been developed to clinically benefit from the positive effects of GLP1 receptor activation

Multiple physiological effects of GLP1 RA, makes it an attractive Type 2 Diabetes therapy.

ADA/EASD guidelines recommends GLP1 RA as the ...................... injectable after metformin & before initiating ......................

GLP1 RAs reduce cardiovascular risk by modifying progression of atherosclerosis (the build up of fatty deposits in the arteries)

GLP1 RAs are recommended by guidelines in ................. patients with ASCVD (Atherosclerotic cardiovascular disease)

Modifications to native GLP1 molecule makes Semaglutide increases its albumin affinity and stability against metabolic degradation by DPP-4 giving it a half life of Approx............... making it suitable for ..................administration

Ozempic (Semaglutide) is administered subcutaneously (abdomen, thigh or upper arm), once weekly (OW) on the same day each week, at any time of the day with or without meals

Ozempic (Semaglutide) will be available in Pakistan as:

Ozempic (Semaglutide) is the most effective once weekly GLP-1 RA treatment for Type 2 Diabetes

No significant drug–drug interactions were observed when semaglutide was administered concomitantly with oral contraceptives, metformin, warfarin, atorvastatin and digoxin?

What are the effects of semaglutide on appetite, energy intake and weight loss?

Semaglutide exposure was not affected by hepatic or renal impairment in patients with T2D; therefore, it may be suitable for such patients without the need for dose adjustment.

The SUSTAIN programme covers all aspects of the T2D patient care continuum, including ----- ---?

Does semaglutide pass the blood–brain barrier?

Semaglutide worsened several aspects of beta-cell function vs placebo in subjects with T2D after 12 weeks of treatment. TRUE OR FALSE