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Ceutics A

Total questions: 101

Worksheet time: 8hrs 8mins

Name
Class
Date
1.

Which of the following profile(s) will exhibit directly proportional relationship?

a)

Absorbance against concentration (S.L. paper)

b)

Solubility against absolute temperature (S.L. paper)

c)

AUC against Dose (R.L. paper)

d)

B and C only

e)

A and C only

2.

Select all that apply. The pKa of weak bases cocaine and morphine are 8.41 and 7.87 respectively. Which if the following statements is/are true?

a)

Kb of morphine is greater than that of cocaine

b)

The degree of ionization of cocaine is greater than that of morphine

c)

Cocaine is a stronger base than morphine

d)

The ionized forms of weak bases morphine and cocaine carry a positive charge

3.

Which of the following is/are considered as acceptable and effective water miscible solvent(s)?

a)

Ethyl alcohol

b)

Sorbitol

c)

Biological buffers

d)

A and B only

e)

A, B and C

4.

Which of the following will exhibit directly proportional relationship when plotted on a R. L. paper?

a)

Porosity against the bulk density

b)

Bulk volume against the weight of the powder

c)

Porosity against the weight of the powder

d)

A and C only

e)

A and B only

5.

Which of the following therapeutic agent belongs to a class of weak basic compound?

a)

Aspirin

b)

Enalapril maleate

c)

Losartan potassium

d)

Sodium naproxen

e)

Penicillin VK

6.

Which of the following dosage form (s) must comply with the content uniformity test?

a)

Immediate release tablet

b)

Hard gelatin capsule

c)

Soft gelatin capsule

d)

A, B, and C

e)

A and B only

7.

Dissociation constant of a drug is often used to describe the acidity and basicity of weak basicity of weak electrolytes. Which of the following statements is false?

a)

The lower the pKa of a weak acidic drug, the stronger is the weak acid

b)

The higher the Ka of a weak basic drug the stronger the weak base

c)

The higher the pKa of a weak basic drug, the stronger the weak base

d)

The lower the pKb of a weak basic drug, the stronger is the weak base

8.

Solubility of a drug is influenced by temperature as well as by the use of a suitable co-solvent. In general, the lower the intrinsic solubility of a compound, the greater will be the magnitude of influence of the temperature and the co-solvent on the solubility of a drug

a)

False

b)

True

9.

Indomethacin is a weak acidic drug with pKa of 4.5. calculate the approximate percentage of indomethacin present as the unionized form in the intestine (pH=6.5). present the numerical value of your answer as a whole number.

a)

1 %

b)

15%

c)

3%

d)

8%

10.

Heat of solution is a property of a solute and it is obtained from the plot of Log of Solubility vs Reciprocal of Absolute Temperature. A negative slope of a plot suggest that the solute is more soluble at higher temperature; and a positive slope suggest that solute is less soluble at higher temperature

a)

True

b)

False

11.

Lipitor (Atorvastatin) is a drug compound with a pKa of 4.46. The solubility of Lipitor is 20.4 mcg/ml at pH 2.1 and 1.23 mg/ml at pH 6. Is Lipitor a weak acid or a weak base?

a)

Weak acid

b)

Wake base

12.

Which of the following physical-chemical property of a therapeutic agent will exhibit higher value as a consequence of particle size reduction?

a)

Specific surface

b)

Porosity

c)

Bulk density

d)

Melting point

e)

A and B only

13.

Select all that apply. A buffer contains an equal molar concentration of a weak acid and its conjugate base. Which of the following statements is/are true? 

a)

Concentration of the weak acid is equal to  β0.575\frac{\beta}{0.575}   

b)

Hydrogen ion concentration of the buffer is equal to the acidic dissociation constant of the weak acid of the buffer

c)

The buffer exhibits maximum buffer capacity

14.

The buffer capacity of a solution is 0.04. calculate the volume of 1N NaOH (m.w. 40 g/mol) to be added to 1 L of the buffer to change the pH by 2 units

a)

20 ml

b)

80 ml

c)

60 ml

d)

40 ml

15.

The pKa of a weakly acidic drug sulphapyridine is 2.4. what is the ratio of ionized to un-ionized sulphapyridine in gastric content (pH 2.0)?

a)

29:1

b)

2:5

c)

5:2

d)

1:29

16.

R.L plot of true volume against the weight of the powder for a newly discovered therapeutic agent yielded the slope value of 0.6134 cc/g. what will be the true volume of 25 g of this therapeutic agent?

a)

25.63 cc

b)

35.55 cc

c)

15.33 cc

d)

40.75 cc

17.

Acetaminophen and Indomethacin are weak acidic drugs with pKa of 9.5 and 4.5 respectively. What is the basic dissociation constant (Kb) of Acetaminophen? Show your calculations

a)

2.5

b)

3.16 * 10-5

c)

4.5

d)

3.16 * 10-3

18.

The strength of a buffer is measured by its buffer capacity which depends solely on the ionic dissociation constant, and hydrogen ion concentration of the buffer system. Is the above statement true or false?

a)

False

b)

True

19.

Physostigmine, a weak base is used to treat glaucoma. At the pH of tears (7.4), what proportion of physostigmine would be present as the free base? Basic dissociation constant, pKb of the weak base is 7.8

a)

6%

b)

94%

c)

72%

d)

28%

20.

Equation for strong acid

a)

pH=12pKw+12pka+12log⁡⁡[C]pH=\frac{1}{2}pKw+\frac{1}{2}pka+\frac{1}{2}\log⁡[C]

b)

pH=12pkw+12pka+12log⁡⁡[2C]pH=\frac{1}{2}pkw+\frac{1}{2}pka+\frac{1}{2}\log⁡[2C]

c)

pH=12pka−12log⁡⁡[2C]pH=\frac{1}{2}pka-\frac{1}{2}\log⁡[2C]

d)

pH=12pKa−12log⁡⁡[C]pH=\frac{1}{2}pKa-\frac{1}{2}\log⁡[C]

21.

In general, a weak base is more ionize or more soluble in aqueous solutions when the pH is higher than its pKa

a)

True

b)

False

22.

The ionization and hydrolysis reactions of Ephedrine Sulfate are as follows. Calculate the pH of 0.1M Ephedrine Sulfate, the pKa of Ephedrine is 9.36


 (EhH)2SO4→2EpH+ +SO4  −2\left(EhH\right)_2SO_4\rightarrow2EpH^+\ +SO_4^{\ \ -2}  
 2EpH+→ 2 Ep +2H+2EpH^+\rightarrow\ 2\ Ep\ +2H^+  

a)

11.18

b)

5.18

c)

5.03

d)

11.33

23.

Cocaine is a weak basic drug. In general, in a system of pH, 4 units less than its pka, cocaine predominantly exists in its;

a)

Unionized form

b)

Ionized form

24.

When a salt of strong acid and strong base is added to water, the salt undergoes hydrolysis and the result solution is neutral.

a)

True

b)

False

25.

Acetyl salicylic acid (pKa=3.9) is a commonly used over the counter medication for mild to moderate pain, fever, and inflammation conditions. The aqueous solubility of an un-dissociated form of aspirin, at room temperature, is reported to be 1g/600ml. if it is desired to prepare an aqueous solution of aspirin containing 325 mg/teaspoonful (5ml), what will be the required pH of the solution?

a)

5.479

b)

5.000

c)

4.579

d)

3.902

26.

Heat of fusion and heat of solution are two terms that accompany the phase transition of a material. The former is associated with the transition from solid to solution and, the latter, from solid to liquid.

a)

False

b)

True

27.

Measurement of a contact angle as well as an angle of repose conceptually involves measurement of an angle; however, the former is used to measure the flow of the powder while the latter is used to measure the hydrophobicity of a powder.

a)

True

b)

False

28.

When it is necessary and required to obtain the value of an intercept from the graph of a straight-line equation, one may use two different available approached. Each approach, however, requires knowledge of the slope of the graph.

a)

False

b)

True

29.

Calculate the pH of a 1% solution of Phenobarbital sodium

a)

10

b)

4.4

c)

9.6

d)

5.1

30.

Which of the following physical-chemical property plays an important role in the formulation of an emulsion dosage form of a drug?

a)

Powder particle size

b)

Partition coefficient

c)

Surface and interfacial tension

d)

Contact angle

31.

Which of the following apply when a therapeutic agent is available in an amorphous form?

a)

It has a high melting point

b)

It is thermodynamically unstable

c)

It is highly compact form

d)

It exhibits poor solubility

e)

It manifests sharp melting point

32.

In general, for a weak basic drug, increasing the pH of urine in the kidney to 2 units greater than pKa of a drug result in;

a)

No effect

b)

Reabsorption of the drug in the kidney

c)

Increase in elimination of the drug through urine

33.

In the human body the absorption of a drug that is a weak electrolyte is determined mainly by the extent to which the drug exists in its ionized form and the site of absorption

a)

False

b)

True

34.

Nitric acid (HNO3) is a strong acid, “Nitric acid ionizes to hydronium ion (H3O+) and its weak conjugate base, nitrate ion (NO3). This ionization reaction is a reversible reaction. Te equilibrium of this reaction in a filute solution shifts to the left”

a)

False

b)

True

35.

The strength of a buffer is measured by its buffer capacity which depends solely on the ionic dissociation constant, and hydrogen ion concentration of the buffer system. Is the above statement true or false?

a)

True

b)

False

36.

In a zero-order reaction, if A0 = 0.47 mole/L and k = 8.2 x 10-4 L/mole/h, what is the half-life of the drug?

a)

24 days

b)

12 days

c)

286 days

d)

845 days

37.

Degradation of a drug was analyzed to be of first order. The formulation initially contained a concentration of 10% w/v of the drug. The half-life of a drug was found to be 7 h. compute the half-life of the same drug formulation with an initial concentration of 30% w/v.

a)

7 h

b)

21 h

c)

2.33 h

d)

Cannot be determined

38.

The pKa of the weakly acidic drug sulphapyridine is 2.4. what is the ratio of ionized to un-ionized sulphapyridine in gastric contents (pH 2.0)?

a)

5:2

b)

2:5

c)

29:1

d)

1:29

39.

Physostigmine, a weak base is used to treat glaucoma. At the pH of tears (7.4), what proportion of physostigmine would be present as the free base? Basic dissociation constant, pKb of the weak base is 7.8

a)

94%

b)

6%

c)

28%

d)

72%

40.

Activation energy (Ea) is an important factor in determining the speed of a reaction or degradation of a drug. If the activation energy required for the molecules to become activated is low, the degradation rate is low. Is the above statement true or false?

a)

True

b)

False

41.

According to Bronsted – Bjerrum theory of effect of ionic strength on degradation rate, if the charges of the reacting species are the same, adding an electrolyte to a liquid formulation may cause stability problems

a)

True

b)

False

42.

Select all that apply. A buffer contains an equal molar concentration of a weak base and its conjugate acid. which of the following statements is/are true?

a)

The buffer exhibits maximum buffer capacity

b)

Hydrogen ion concentration of the buffer is equal to the basic dissociation constant (kb) of the weak base of the buffer

c)

Concentration fo the weak base = B/0.575

d)

Hydrogen ion concentration of the buffer is equal to the acidic dissociation constant (ka)of the weak base of the buffer

43.

The buffer capacity of a solution is 0.04. calculate the volume of 2N NaOH (Mol. Wt. 40) to be added to 1L of the buffer to change the pH by 2 units.

a)

20 ml

b)

40 ml

c)

60 ml

d)

80 ml

44.

The refractive index (n) of a material is a dimensionless number that describes how light propagates through that material. The refractive index (n) for a material besides the air is __________.

a)

More than 1

b)

Smaller than 1

c)

The multiplication of the refractive index (n) of the air and the light velocity in the air

d)

The light velocity in the material divided by the light velocity in the air

45.

The permeability coefficient of a weak electrolyte through a biological membrane will increase if:

a)

The molecular weight of the drug increases

b)

The surface area of the drug particles increases

c)

The partition coefficient increases

d)

The drug dissolution rate increases

46.

1. In USP dissolution testing, _________ hydrochloric acid is used to simulate gastric fluid

a)

1M

b)

0.1M

c)

10M

d)

0.01M

47.

500mg of a non-electrolyte drug (MW=250) was shaken with 100 mL of 1:1 (v/v) of octanol/water mixture. The concentration of the drug in the aqueous layers was found to be 1 x 10-2M. calculate the apparent partition coefficient of this drug at pH=2.

a)

1

b)

The apparent partition coefficient cannot be determined from the information provided by this equation

c)

3

d)

2

48.

Which equation(s) can be used to describe the rate of drug dissolution from a tablet? Select all that apply.

a)

Michaelis-Menten equation

b)

Henderson-Hasselbalch equation

c)

Hixson-Crowell Cube Root relationship

d)

Noyes-Whitney equation

49.

Which statement about the lag-time and burst time effect is true?

a)

Both the lag time (tL) and the burst time (tB) are dependent of diffusion coefficient of the drug and the thickness of the membrane.

b)

Only the lag time (tL) but NOT the burst time (tB) is dependent on the diffusion coefficient of the drug and the thickness of the membrane

c)

Lag-time effect is observed in systems that have been stored for a long time and the rate controlling membrane is pre-saturated with the drug

d)

Neither the lag time(tL) nor the burst time(tB) is dependent on the diffusion coefficient of the drug and the thickness of the membrane

50.

The liquid film constitutes a stationary diffusion layer in which the concentration of the drug is _________.

a)

Smaller than the drug solubility (Cs)

b)

Greater than the drug solubility (Cs)

c)

Equal to the drug solubility (Cs)

d)

Unknown.

51.

The octanol-water distribution plot (1/Papp vs 1/[H+]) for a weak acid has a y-axis intercept of 4.5*10-4 and a slope of 5.8*10-6. Calculate logP and pKa for this weak acid.

a)

LogP =5.16, pKa=1.71

b)

LogP =1.89, pKa=3.35

c)

LogP =3.35, pKa=1.89

d)

LogP =1.71, pKa=5.16

52.

Which statement is true about dissolution?

a)

Dissolution is usually an exothermic process

b)

The sink condition for Noyes-Whitney equation refers to the drug concentration in bulk solution (Cb) is much smaller than the drug solubility (Cs)

c)

In diffusion layer model, the drug concentration in the stationary liquid film forming on the surface of the particle is larger than the drug solubility (Cs)

d)

The solubility of a compound usually decreases when the temperature increases

53.

Which statement is true about the active transport?

a)

The active transport moves the drug molecules from a higher drug concentration region to a lower drug concentration region.

b)

The active transport follows Fick’s first law of diffusion

c)

The active transport requires energy

d)

The active transport follows Fick’s second law of diffusion

54.

Calculate the total concentration of an acid preservative that must be added to preserve an emulsion composed of equal volumes of oil and water and the aqueous phase is buffered at pH 7. The minimum effective concentration for this acid preservative is 0.05mg/ml. Ka = 3.8 x 10-5. P = 25.

a.

b.

c.

d.

a)

2mg/mL

b)

2g/L

c)

20mg/mL

d)

200mg/mL

55.

Diffusivity reflects the rate at which a diffusant is transported between two regions. Diffusivity of a diffusant

a)

Is higher when the diffusant diffuses in a diffusional barrier with a higher viscosity

b)

Is smaller when the temperature of the whole system is higher

c)

Has a unit as length/time

d)

Is higher when the Strokes radius of the diffusant is smaller

56.

Which of the following drug(s) belongs to BCS class IV? Select all that apply

a)

Propranolol

b)

Naproxen

c)

Furosemide

d)

Metoprolol

57.

A drug’s granules having a total surface area of 0.48x10^4 cm2 are allowed to dissolve in plenty of water at 25 C. After the first minute, 1.68 g have passed into solution. if the solubility (Cs) of the drug is 32 mg/ml at 25 C, what is k, the dissolution rate constant?

a)

1.82x10-4 cm/s

b)

1.82x10-3 cm/s

c)

1.82x10-4 cm2/s

d)

1.82x10-3 cm2/s

58.

Heat of solution is a property of a solute, which is obtained from the plot of log of solubility versus reciprocal of absolute temperature. A negative slope of a plot suggests that the solute is less soluble at higher temperature; and a positive slope suggests that solute is more soluble at a higher temperature

a)

True

b)

False

59.

Which of the following physical-chemical properties is/are dimensionless (i.e., no unit) (select all that apply)

a)

Partition coefficient

b)

Absorptivity

c)

Specific surface

d)

True density

e)

Porosity

60.

Which of the following is a desirable physical-chemical property of a therapeutic agent for the formulation of an oral suspension dosage form?

a)

Poor aqueous solubility

b)

High aqueous solubility

c)

Low true density

d)

High bulk density

e)

Low porosity

61.

Which of the following physical-chemical properties of a therapeutic agent will have identical dimension (i.e., unit)? (select all that apply)

a)

Heat of solution

b)

Absorbance

c)

Absorptivity

d)

Equilibrium solubility

e)

Energy of activation

62.

Which of the following physical-chemical properties of a solid therapeutic agent will be influenced as a result of the particle size reduction? (select all that apply)

a.

b.

c.

d.

a)

Porosity

b)

Heat of repose

c)

Angle of repose

d)

Equilibrium solubility

e)

Melting point

63.

Which of the following profile (s) will exhibit directly proportional relationship on a R.L paper? (select all that apply)

a.

b.

c.

d.

e.

a)

Absorbance against concentration

b)

Solubility against 1/T

c)

True volume against the weight of powder

d)

True density against weight of the powder

e)

Porosity against particle size

64.

Which statement is true about the Fick’s first law of diffusion?

a)

Fick’s first law of diffusion states that the diffusion flux (J) along direction x is proportional to the concentration gradient (dC)

b)

Fick’s first law of diffusion indicates diffusion occurs in the direction of increasing concentration

c)

Fick’s first law of diffusion describes non-steady-state diffusion

d)

Fick’s first law of diffusion describes a situation that the concentration gradient (dC) is changing with time

65.

There are some striking differences between the S.L. plots of log of solubility against reciprocal of absolute temperature and log of degradation rate constant against reciprocal of absolute temperature; the slope of the former one yields the heat of solution of a drug while, the slope of the latter one, provides the energy of activation of a drug

a)

True

b)

False

66.

Which of the following excipient, when used in a tablet dosage form, facilitates the dissolution of a hydrophobic therapeutic agent?

a)

Diluent

b)

Lubricant

c)

Surface active agent

d)

Glidant

e)

Disintegrating agent

67.

Which of the following weakly basic therapeutic agents will exhibit the strongest basicity?

a)

Diazepam (pKa = 11)

b)

Alprazolam (pKa = 11.6)

c)

Oxazepam (pKa = 12)

d)

Morphine (pKa = 7.87)

68.

The Y-axis of Hixson-Crowell plot is the cube root of the amount of the drug remaining. What is the Y-intercept of the Mt1/3 vs time line?

a.

b.

c.

d.

a)

M01/3, the cube root the amount of drug at time zero

b)

K, the cube root dissolution rate constant

c)

M0, the amount of drug at time zero

d)

1/K, the reciprocal of the cube root dissolution rate constant

69.

Therapeutic agents are often available in crystalline and amorphous forms. The crystalline form tends to possess greater thermodynamic energy and, therefore, greater aqueous solubility, faster dissolution rate, and faster rate of absorption.

a)

True

b)

False

70.

Which of the following form (s) of a therapeutic agent is/are likely to exhibit faster dissolution and, therefore, faster absorption?

a.

b.

c.

d.

e.

a)

Amorphous

b)

Crystalline

c)

Stable polymorph

d)

Hydrophobic

e)

Hydrous

71.

Which of the following apply when a therapeutic agent is available in an amorphous form?

a)

It is thermodynamically unstable

b)

It manifests sharp melting point

c)

It exhibits poor solubility

d)

It is thermodynamically stable

e)

It is ideal for the formulation of a suspension dosage form

72.

Phenobarbital is a weak acidic drug. Overdose of phenobarbital results in increase in amount of phenobarbital crossing the blood-brain barrier which might result in coma. Phenobarbital poisoning can be treated by altering the plasma pH, which results in increase in elimination of phenobarbital through the urine. This result can be attained by which one of the following techniques?

a)

Lowering plasma pH by administering ammonium chloride

b)

Increasing plasma pH by administering sodium bicarbonate

c)

None of the above

73.

A drug was found to be stable for 1 year at room temperature. How long may the drug be theoretically stable at refrigerated temperature?

a)

0.25 years

b)

0.04 years

c)

4 years

d)

25 years

74.

Which statement is true about melting point depression?

a)

For the same compound, the purer the compound, the higher the melting point and the broader the melting point range

b)

For the same compound, the purer the compound, the lower the melting point and the broader the melting point range

c)

For the same compound, the purer the compound, the higher the melting point and the narrower the melting point range

d)

For the same compound, the purer the compound, the lower the melting point and the narrower the melting point range

75.

The ampicillin monograph states that the reconstituted suspension is stable for 14 days in a refrigerator (5oC). if the product is left at room temperature for 12 h, what is the reduction in the expiration period?

a)

12 days

b)

2 days

c)

16 days

d)

1.5 days

76.

The degradation rate constant of a reaction is 3.45 mg/mL.s. what would the order of reaction be?

a)

Zero

b)

One

c)

Two

d)

None of the above

77.

Which of the following description is true?

a)

The phase transitions among the polymorphs of sulfur are irreversible

b)

The phase transitions among the polymorphs of glyceryl sterate are reversible

c)

The phase transitions among the polymorphs of sulfur are exothermic

d)

The glyceryl sterate polymorph with highest melting point is always more thermaldynamically stable than other polymorphs of glyceryl sterate

78.

Which statement is true about the glass transition of a material?

a)

Compounds have a higher heat capacity above the glass transition temperature than they do below it

b)

Compounds have less mobility above the glass transition temperature than they do below it

c)

The glass transition is a first order transition because of the latent heat involved in

d)

Completely amorphous compounds do not represent glass transition

79.

Which statement is true about polymorphism?

a)

All the polymorphous of a compound usually have similar dissolution behavior

b)

The differences between polymorphs exist in all the states of matter

c)

All the polymorphs of a compound have the same molecular weight

d)

Polymorphism is not common in barbiturates and steroids

80.

Effect pf solvent on degradation rate constant is being observed. The charges on the drug ion and the interacting species are the same. Replacing water with a solvent of lower dielectric constant (E) will result in

a)

Increase in degradation

b)

Decrease in degradation

c)

No change in degradation

81.

Effect of added electrolytes (increase in ionic strength) on degradation is being studied for a drug product. One of the interacting species in the degradation reaction is a neutral molecule. Increasing the ionic strength by adding more electrolytes to the drug product would result in ____________.

a)

Increase in rate of degradation

b)

Decrease in rate of degradation

c)

No change in degradation rate

d)

Slight increase initially followed by a decrease in degradation rate

82.

Packing the drug product that is known to degrade by oxidation, in a heavy metal container or foil protect the drug product from oxidative degradation. Is the above statement true or false?

a)

True

b)

False

83.

The relationship between the vapor pressure and the absolute temperature (T) of a liquid is expressed by which equation

a)

Henderson-Hasselbach

b)

Arrhenius

c)

Clausius-Clapeyron

d)

Strokes-Radius

84.

Which S.L graph paper will be appropriate if you wish to plot solubility against reciprocal of absolute temperature for 11mg/ml, 39mg,ml, and 121 mg/ml at 25 , 45, and 55 degrees Celsius respectively?

a)

Three cycles

b)

One cycle

c)

Log log paper

d)

Two cycles

85.

Which of the following represents a class of weak acidic therapeutic agent? Select all that apply.

a)

Flecainde acetate

b)

Diclofenac potassium

c)

Amlodipine besylate

d)

Ibuprofen

e)

Citalopram hydrobromide

86.

Which of the following is/are considered as fundamental pharmacokinetics parameters of a drug?

a)

Rate of absorption

b)

Systemic clearance

c)

Peak plasma concentration

d)

Peak time

e)

Creatine clearance

87.

Which of the following liquid will exhibit the highest specific gravity?

a)

Glycerin

b)

Acetone

c)

Ethyl alcohol

d)

Water and acetone mix

e)

Distilled water

88.

Which of the following will influence the partition coefficient of a therapeutic agent?

a)

Absorptivity

b)

Angle of repose

c)

Chemical structure

d)

True density

e)

The volume of distribution

89.

According to log P, which drug may have the lowest aqueous solubility?

a)

Ritonavir      

b)

 Penicillin G

c)

Acetaminophen

d)

Ampicillin

90.

According to log P, which drug may have the lowest aqueous solubility?

a)

Ritonavir 

b)

Penicillin G 

c)

Acetaminophen 

d)

Ampicillin

91.

Which solvent is the least polar solvent?

a)

Acetone

b)

Glycerin

c)

Propilene glycel

d)

Chloroform

92.

Which statement is true about crystallization or crystal?

a)

A completely amorphous compound can have crystallization.

b)

Crystallization is an endothermic process.

c)

A crystal cannot be formed directly from another crystal.

d)

The heat of crystallization is a latent heat.

93.

The melting point and molar heat of fusion for a compound are 85°C and 4005cal/mol, respectively. Which of the following is true regarding the solubility of this compound at 20°C in an ideal solution?

a)

0.306 mole of this compound per mole water

b)

0.287 mole of this compound per mole water

c)

0.306 mole of this compound per 0.694 mole water

d)

0.287 mole of this compound per 0.713 mole water

94.

Which technique is usually used to investigate the dimensional change of a compound when the temperature changes?

a)

Thermogravimetric analysis

b)

High performance liquid chromatography

c)

Differential scanning calorimetry

d)

Thermomechanical analysis

95.

The octagonal-water distribution plot (1/P app vs 1/[H+]) for a weak acid has a Y-axis intercept of   5×10−35\times10^{-3}   and a slope of  5×10−65\times10^{-6}  . Calculate logP and pKa for this weak acid.

a)

 Log P=2.3, pka=3Log\ P=2.3,\ pk_a=3  

b)

 LogP=3, pKa=2.3LogP=3,\ pK_a=2.3  

c)

 LogP=3, pKa=5.3LogP=3,\ pK_a=5.3  

d)

 LogP= 5.3, pKa=3LogP=\ 5.3,\ pK_a=3  

96.

Which of the following apply when a therapeutic agent is available in an amorphous form?

a)

It has a high melting point

b)

It manifests sharp melting point

c)

It is highly compact form

d)

It exhibits poor solubility

e)

It is thermodinamically unstable

97.

Which of the following will exhibit directly proportional relationship when plotted on a R. L. paper?

a)

Porosity against the bulk density

b)

Bulks volume against the weight oh the powder

c)

Bulk volume against particle size

d)

Solubility against absolute temperature

e)

Porosity against the weight of the powder

98.

Select all that apply. No partial credit.


The pKa of weak bases cocaine and morphine are 8.41 and 7.87 respectively. Which of the following statements is/are true?

a)

Cocaine is a stronger base than morphine

b)

Kb of morphine is greater than that of cocaine.

c)

The ionized forms of a weak bases morphine and cocaine carry a positive charge

d)

The degree of ionization of cocaine is greater than that of morphine

99.

Select all that apply. No partial credit.

A buffer contains an equal molar concentration of a weak acid and its conjugate base. Which of the following statements is/are true?

a)

Concentration of the weak acid is equal.

b)

The buffer exhibit maximum buffer capacity

100.

Nitric acid (HNO3) is a strong acid "Nitric acid ionizes to hydronium ion (H3O+) and its weak conjugate base, nitrate ion (NO3). This ionization reaction is a reversible reaction. The equilibrium of this reaction in a dilute solution shifts to the left.

a)

True

b)

False

101.

Acetaminophen and Indomethacin are weakacidic drugs with pKa of 9.5 and 4.5 respectively. Degree of ionization of Acetaminophen is greater than that of the Indomethacin.

a)

True

b)

False

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