WorksheetsTranslational regulation & protein folding
Total questions: 14
Worksheet time: 8mins
Which of these are global mechanisms to regulate translation?
Non-sense Mediated Decay
Codon usage
phosphorylation of eIF2 & eIF2B
mRNA stability
phosphorylation of 4E-BPs
Secondary structures located at the 5' UTR
enhance translation
slow down translation
have no effect on translation
IRP is an example of a
Carrier protein
Repressor protein
Enhancer protein
miRNA and the RISC regulate translation at what stage
elongation stage
initiation stage
termination stage
Which triggers faster degradation?
siRNA
miRNA
Phosphorylation of eIF2 & eIF2B result in
negative regulation
positive regulation
Which kinase phosphorylates 4E-BPs?
PKR (protein kinase R)
mTOR
eIF4E
Protein disulfide isomerase is found in the
nucleus
ER lumen
mitochondria
lysosomes
cytoplasm
------ have complete complementarity while --------- have mismatches.
miRNA, siRNA
siRNA, miRNA
RISC, RITS
RITS, RISC
--------- sequences, allow viruses to bypass the cap-dependent mechanism of translation
IRP
IRE
IRES
ORF
What dictates the final folded structure of a protein is its
primary structure
secondary structure
tertiary structure
quaternary structure
To prevent protein aggregation, ___________ bind to hydrophobic patches, and ___________ provide an isolated space for proteins to fold properly.
chaperonins, chaperones
chaperones, chaperonins
PDI enzymes, the ER
PDI requires an __________ environment.
oxidizing
reducing
positive
negative
Alzheimer's disease is associated with the improper folding of what protein?
collagen I
Huntingtin
Amyloid Precursor Protein
prions
