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WorksheetsPharmaphilia (PHARMACODYNAMICS)
Total questions: 20
Worksheet time: 11mins
Example(s) of second messenger effect(s
A) increases in cAMP intracellular concentration
B) changes in intracellular calcium concentration
C) Inositol triphosphate and DAG effects
D) all the above
EC50 mainly reflexs a drug's .................
A) maximal effect
B) potency
C) lethality
D) ease of elimination
E) safety
Receptors are usually :.........................
A) lipids
B) proteins
C) Carbohydrates
An example of a receptor which is a structural protein is .................
ca+ channel
acetylcholinesterase pump
C) cAMP
D) DNA
E) mRNA
Pharmacodynamics involves the following?
a) Information about main mechanisms of drug absorption
b) Information about unwanted effects
c) Information about biological barriers
d) Information about excretion of a drug from the organism
Pick out the answer which is the most appropriate to the term “receptor”.........
a) All types of ion channels modulated by a drug
b) Enzymes of oxidizing-reducing reactions activated by a drug
c) Active macromolecular components of a cell or an organism which a drug molecule has to combine with in order to elicit its specific effect
d) Carriers activated by a drug
e) all of them
What does “affinity” mean?
a) A measure of how tightly a drug binds to plasma proteins
b) A measure of how tightly a drug binds to a receptor
c) A measure of inhibiting potency of a drug
d) A measure of bioavailability of a drug
An agonist is a substance that: .........
a) Interacts with the receptor without producing any effect
b) Interacts with the receptor and initiates changes in cell
c) Increases concentration of another substance to produce effect
d) Interacts with plasma proteins and doesn’t produce any effect
If an agonist can produce maximal effects and has high efficacy it’s called:
a) Partial agonist
b) Antagonist
c) Agonist-antagonist
D) Full agonist
An antagonist is a substance that: ....................
a) Binds to the receptors and initiates changes in cell function, producing maximal effect
b) Binds to the receptors and initiates changes in cell function, producing sub-maximal effect
c) Interacts with plasma proteins and doesn’t produce any effect
d) Binds to the receptors without directly altering their functions
Mechanisms of transmembrane signaling are the following EXCEPT:....................
a) Transmembrane receptors that bind and stimulate a protein tyrosine kinase
b) Gene replacement by the introduction of a therapeutic gene to correct a genetic effect
c) Ligand-gated ion channels that can be induced to open or close by binding a ligand
d) Transmembrane receptor protein that stimulates a GTP-binding signal transducer protein (G-protein) which in turn generates an intracellular second messenger
Tick the second messenger of G-protein-coupled (metabotropic) receptor: ........................
a) Adenylyl cyclase
b) Sodium ions
c) Phospholipase C
d) cAMP
The increase of second messengers’ (cAMP, cGMP, Ca2+ etc.) concentration leads to:.........................
a) Inhibition of intracellular protein kinases and protein phosphorylation
b) Proteinkinases activation and protein phosphorylation
c) Blocking of interaction between a receptor and an effector
d) Antagonism with endogenous ligands
All of the following statements about efficacy and potency are true EXCEPT: .................................
a) Efficacy is usually a more important clinical consideration than potency
b) Efficacy is the maximum effect of a drug
c) Potency is a comparative measure, refers to the different doses of two drugs that are needed to produce the same effect
d) The Emax is a measure of drug’s efficacy but ED50 is a measure of drug's potency
Agonist is ...................................
A) Prevents the binding of the active drug, as its main function.
B) Agonists initiate changes in cell function, after binding to their receptor, producing effects of various types.
C) Potency is independent on their affinity for the receptor
D) Potency or efficacy does not depend on the drugs ability to initiate changes once bound to the receptor.
This type of receptors is located intracellular and activated by gene transcription
true
False
cAMP and cGMP are considered …………………………………
(a)
Which of the following terms best defines the intrinsic ability of a drug to bind to a receptor in case of
A 16-year-old girl suffering from seasonal rhinitis started a therapy with loratadine, a drug that binds to H1 histamine receptors.
A) potency
B) Efficacy
c) Affinity
D) Idiosyncrasy
E) both of A & C
A 57-year-old man, who was in the hospital after a
surgical operation and the prescribed drugs were morphine (10 mg IM) and buprenorphine
(0.3 mg IM). Morphine is a full agonist at opioid mu receptors whereas
buprenorphine is a partial agonist at the same receptors. The above
mentioned doses of the two drugs are equieffective doses. Which of the
following pairs of statements correctly defines the potency and efficacy
of morphine and buprenorphine?
A) the effect will increase (Agonist)
B) the effect will remain constant
C) the effect will decrease ( Antagonism )
D) buprenorphine is more effective than morphine
E) Morphine is more potent than buprenorphine
a5bar dma3'ak a delwa2ty yaCta ? ... bl shefa :D
