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WorksheetsSTC assessment 3
Total questions: 20
Worksheet time: 15mins
What is the function of CRISPR-Cas system in bacteria
Plasmid transformation
Protection from invading viruses
Gene regulation
Protein translation
For CRISPR system to work it needs
CRISPR RNA
Cas protein
Anti-CRISPR protein
Both CRISPR RNA and Cas protein
CRISPR Genome editing using NHEJ (non-homologous end joining) pathway will result in
Gene knock-out
Down regulation of gene expression
Gene replacement
All of the above
Essential genes cannot be silenced using CRISPR-Cas
True
False
CRISPR-Cas system cannot be used for activation of gene expression
True
False
Cas9 can cut DNA in vitro
True
False
If Sa, the first note has frequency 250hz then Pa, the one that is at the mid of the Saptak (Octave) of Hindustani Classical Music will be at _______
125
375
50
data inadequate
Would all mix and match (Crossover in GA) products be novel?
Yes
No
May be
60% of them will be novel
To get the best breed it is recommended that _______
All the weak breeds are to weed out
A few weak breeds are to be retained
Weak and Strong breeds are to be taken in equal amount
None of the above
How many three letter sequences are available in the 4-symbol language AGTC?
64
less than 64
greater than 64
Infinitely many
Odd entity out (Context: Big data and AI): Regression, ANN, GA, SVM, Decision trees
Decision trees
ANN
Regression
None of these
Roughly how many reads will have a heterozygous somatic mutation specific to tumor cells if you generate 1000X coverage of sequencing of genomic DNA from a tissue containing 5% tumor cells.
50
25
5
None of the above
The M in RPKM stands for
Micro
Majority
Milligram
Million
The insert size in mate-pair is used to
Split the contigs
Join the contigs
Evaluate the lengths of contigs
None of the above
Which step was automated between sanger to NGS
Use florescent labeled dinucleotide
Synthesis by polymerase
Amplification by DNA fragments by cloning
Parallel amplification by DNA fragments by PCR
GreenGene database does not consists of
Aligned fasta file of all known 16S rRNA
Sequences of all known 16S rRNA
3D structure of 16S rRNA
Taxonomy for each 16S rRNA
Which of the following is not a molecular biology platform ?
FISH
NGS
Karyotyping
Flow Cytometry
Which molecular biology platform is being utilized for most accurate testing of Covid 19?
PCR
FISH
NGS
CMA
Trisomy of which chromosome causes Down’s Syndrome ?
13
21
18
5
Which of the following is the reason for prevalence of genetic disorders in some communities ?
Endogamy
Consanguineous marriages
Founder mutations
All of the above
