WorksheetsMalaria - Pathologic Process
Total questions: 12
Worksheet time: 8mins
What do you call the electron-dense sub-membranous structures that appear and enlarge during invasion of merozoites in erythrocytes? They play an important role in cytoadhesion.
(a)
KNOBS
- most adhesive protein encoded by the var multigene
family, and is clonally variant thus enabling it to evade specific immune responses; also discovered to be responsible for the heat-induced cytoadherence of the ring-staged P. falciparum erythrocytes
Rosettins
PfEMP-1
HRP
KNOBS
- ligands for rosette formation
- adheres to parasitized and nonparasitized cells as well as blood platelets
PfEMP-1
Rosettins and PfEMP-1
HRP
KNOBS
- localize to cytoadherence ligands to make adhesion more effective
PfEMP-1
Rosettins and PfEMP-1
HRP
Antigen
- linked to surface antigens of P. falciparum; act like endotoxin of gram-negative bacteria (LPS); stimulate monocytes to release TNF or cachexin (causes malarial fever)
(a)
Complications
- Severe forms of malaria
Tuberculosis
Bone marrow cancer
Severe hemolytic anemia
Respiratory findings
Cerebral malaria
60% of untreated severe P. falciparum infections lead to (a) which occur more among males.
Falciparum malaria affects pregnancy and may lead to premature labor.
True
False
Malaria in children is not fatal.
True
False
Severe hyperextension observed in children w/ malaria.
(a)
Infant malaria
- Parasitemia documented within 7 days of life, manifestations observed several weeks after prepatent period
Congenital malaria
Conatal/Neonatal malaria
Infant malaria
- parasitemia documented after 7 days but no more than 28 days of life; manifestations observed in the later course of the disease
Congenital malaria
Conatal/Neonatal malaria
