Dohle bodies are seen in which of the following?

Malignant hyperplasia of the multipotential myeloid stem cell causes an increase in all cell lines.

Laboratory: Bone marrow plasma cells >30%, marked rouleaux, increased erythrocyte sedimentation rate (ESR), the blue background to blood smear, plasma cells and lymphocytes on a blood smear. Presence of Bence Jones proteins in the urine

What is the term for cell movement through blood vessels to a tissue site?

Which of the following represents the principal defect in chronic granulomatous disease (CGD)?

Which of the following are the contents of basophilic granules?

The nucleus is a dumbbell or peanut-shaped referred to as “pince-nez”

Laboratory: Pancytopenia; cytoplasm of lymphocytes shows hair-like projections; hairy cells are tartrate-resistant acid phosphatase (TRAP) stain positive

Laboratory: Neutropenia, anemia, and thrombocytopenia; variable WBC count; hypercellular marrow with bone marrow blasts >20% (WHO) or >30% (FAB)

Transport non-heme iron across the mucosal membrane of the intestines

Plummer-Vinson Syndrome includes the following except:

The only vitamin exclusively synthesized by microorganisms

Characterized by reduced reticulocyte response accompanied by low serum iron despite adequate iron stores with the presence of high levels of cytokines

Associated with marrow replacement by abnormal cells or tissue component such as metastatic carcinoma, multiple myeloma, leukemia, lipidoses, or storage disease

Laboratory findings are those of a chronic extravascular hemolytic process: evidence of increased pigment catabolism, erythroid hyperplasia, and reticulocytosis

In sickle cell disease, the glutamic acid in the sixth position on the β-chain is replaced by ____________

A subgroup of alpha-thalassemia characterized by one defective gene

A 24-year-old woman was rushed to the emergency room due to severe anemia secondary to pneumonia. Genetic studies show her red cells have increased susceptibility to oxidation during intercurrent illness. Peripheral blood shows poikilocytes, some spherocytes, bite cells, and irregularly contracted cells.

A type of polycythemia wherein the red cell mass is often high normal and the plasma volume is low normal and patients with these type have been regarded as an extreme of the normal physiologic state