WorksheetsFUNDA L11-25
Total questions: 28
Worksheet time: 18mins
movement of pharmacokinetics
absorption
distribution
metabolism
elimination
magnitude of drug action depends on
bound form
free form
cell proliferation is driven by growth factors
TRUE
FALSE
liver regeneration occurs by
proliferation of remaining hepatocytes
repopulation from progenitor cells
development of mature cells from stem cells
in viral replication, once ________ occurs, it will enter eclipse phase
penetration
uncoating
release
assembly
virus composed of genome & protein
TRUE
FALSE
first pass can be prevented by administering drug
orally
parenteral
sublingual
constant amount of drug eliminated
first order elimination
zero order elimination
results in producing sub (less than) maximal effect
agonist
competitive agonist
partial agonist
what are the pathways of intracellular accumulation
inadequate removal of normal substance
failure to degrade a metabolite
accumulation of an abnormal endogenous substance
deposition & accumulation of an abnormal exogenous substance
what can be seen in intracellular protein accumulation
russell bodies
dutcher bodies
gaucher cells
"golden yellow to brown" is a characteristic of
melanin
lipofuscin
hemosiderin
metastatic calcification is commonly due to
PTH excess
destruction of bone
calcium deposits in injured/dead tissue
renal failure
moulds are
unicellular fungi
multicellular fungi
TRUE statements of fungi
not a heterotroph
cell wall made up of chitin & glucan
cell membrane consists of ergosterol
yeast is a unicellular fungi
autosomal dominant
manifested in heterozygous state
manifested in homozygous state
has reduced penetrance
has complete penetrance
Gaucher cells is due to accumulation of metabolic intermediate glucocerebrocide in macrophages
TRUE
FALSE
ring chromosome is due to
chromosomal portions are lost from both ends
centromere divides horizontally instead of vertically
loss of portion of chromosome
chromosome breaks at 2 sites & broken segment rejoins in an inverted manner
TRUE statements regarding trematodes
leaf like
tape like
no suckers
hermaphrodite (except schistosomes)
TRUE statements on BENIGN neoplasms
localized
well circumscribed
invasive
grow by expansion (often w formation of a capsule of compressed fibrous tissue)
"malignant neoplasm of epithelial cells" is the definition of
sarcoma
carcinoma
pathways of cancer dissemination
lymphatic spread
hematogenous spread
seeding within body cavities
which antibodies are formed first in Primary Response
IgG
IgM
IgA
hapten
incomplete antigen
complete antigen
contraindications of anti-inflammatory drugs are
peptic ulcer
DM
psychosis
osteoporosis
"inhibit COX 1 & 2 and prostaglandin, hence reducing pain & inflammation" is the MOA for
NSAIDs
glucocorticoids
DMARDs
colchicine
interferon molecules induce other healthy cells to produce translation inhibiting proteins (TIP), which are mixtures of _______ enzymes
protein kinase
oligonucleotide synthetase
ribonuclease
what are the therapeutic effects of drugs
curative
symptomatic / palliative
prophylaxis / preventive
tolerance
