Adverse effects of Mecasermine

What is the most common adverse effect of Mecasermine?

A carbohydrate-rich food or a snack is taken 20 minutes before/after administration of this drug

Complex of recombinant human IGF-1 (rhIGF-1) and recombinant human insulin-like growth factor binding protein- 3 (rhIGFBP-3)

• Synthetic GHRH

• Distinguish whether hypothalamic or pituitary deficiency

Synthetic analogs of somatostatin

- Most widely used somatostatin analog

- 45 times more potent than somatostatin in inhibiting GH release

- Half-life: 80 minutes (30x longer than somatostatin)

- Given 50-200mcg SC every 8 hours

Therapeutic Uses

- Treatment of Acromegaly

- Sever watery diarrhea (secretory and HIV associated)

- Flushing associated with carcinoid tumors

- Diabetes, Chemotherapy, or Radiation induced

- Portal Hypertension

- Acute control of bleeding esophageal varices

Adverse effects

- Diarrhea

- Abdominal pain

- Flatulence

- Nausea

- Steatorrhea w/ bulky bowel movements

Adverse effects

Cardiac effects

- Sinus bradycardia

- Conduction disturbance

Adverse effects

- Pain at site of infection

- Vitamin B12 deficiency

Adverse effects

Long-term use of Somatostatin, ___________, and __________ cause asymptomatic cholesterol gallstones

Octapeptide somatostatin analog approved for treatment of acromegaly

Growth Hormone receptor antagonist used to treat acromegaly

Does not inhibit GH secretion and may lead to increased GH levels and possible adenoma growth

Adverse effects

No serious problems have been observed however, increases in liver enzymes without liver failure have been reported.