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Column Chromatography 1

Total questions: 9

Worksheet time: 5mins

Name
Class
Date
1.

It is a technique or method used to separate mixtures of dissolved chemicals/substances.

a)

chromatography

b)

solution

c)

chromatogram

d)

evaporation

2.

In size exclusion chromatography, the higher the degree of cross-linking of the gel polymer, ………..

a)

the lower the mechanical strength and the larger the molecular sieving range.

b)

the higher the mechanical strength and the larger the molecular sieving range.

c)

the lower the mechanical strength and the smaller the molecular sieving range.

d)

the higher the mechanical strength and the smaller the molecular sieving range.

3.

In gel permeation chromatography, a type of size exclusion C, which of the following is correct?

a)

Compressible gels are commonly used.

b)

Spherical bead shape is preferred.

c)

Mechanical strength increases with large particle size.

d)

Gels with large bead size are preferred.

4.

Q. Chromatography is generally used for the separation of mixtures based on the differences in their

a)

shape

b)

size

c)

structure

d)

all of the above

5.

Ion-exchange chromatography is used for the separation of

a)

polar molecules

b)

nonpolar molecules

c)

none of the above

d)

all of the above

6.

Which chromatographic technique depends on the highly specific interactions between pairs of biological materials such as enzyme-substrate?

a)

ion exchange chromatography

b)

affinity chromatography

c)

adsorption chromatography

d)

igel permeation chromatography

7.

In gel filtration (size exclusions) chromatography, separation of proteins are based on their

a)

size and net charge

b)

size and shape

c)

size and specific affinity

d)

shape and net charge

8.

Which polymer is often used for matrix materials in Affinity chromatography

a)

Agarose

b)

cellulose

c)

dextrose

d)

all of the above

9.

In anion exchange chromatography,

a)

the column contains positively charged beads where negatively charged proteins bind

b)

the column contains negatively charged beads where positively charged proteins bind

c)

the column contains negatively & positively charged beads where proteins bind depending on their net charge

d)

all of the above