WorksheetsLevemir Quiz
Total questions: 20
Worksheet time: 11mins
Insulin detemir Major site of Protraction at
Subcutaneous depot
Circulation
Interstitial fluid
The protracted action of insulin detemir is mediated by a combination of self association of insulin detemir molecules at the injection site and albumin binding via the
A chain
myristic acid side chain
B chain
Hexamer chain
Nocturnal Hypoglycaemia is termed as
Hypoglycaemia during day time
Hypoglycaemia during sleep particularly at night from 12am to 6am
Hypoglycaemia with symptoms
Hypoglycaemia during afternoon sleep
Important limitations of us of levemir is
recommend for diabetic ketoacidosis
recommended in six month baby
Use intravenous
pregnancy in 1st Trimester
Levemir should be discarded ......days after it is first kept out of the refrigerator
38 days
42 days
35 days
30 days
Detemir has a ..... time action profile with similar duration of action vs glargine
Comparable
Equal
24 hours vs 18 hours
IDet shows......within patient variability in glucose lowering effect compared with NPH insulin and IGlar
Same
Comparable
Less
With very small difference
In the TITRATE study the majority of patients achieved HbA1c .....with low rates of hypoglycaemia using detemir
<6.5%
<7.0%
7.5%
Onset levemir is
12 hours
1.5 to 2 hours
5 to 7 hours
3.5 to 4 hours
Peak time of levemir is
Only 1 hour
Peakless
With small variations
1.5 to 2 hours
MEX Serum concentration of levemir
Peakless
5 to 7 hours after administration
6 to 8 hours after administration
12 hours after administration
Bioavailability of levemir is
98%
60%
48%
68 %
LEVEMIR has a pH of approximately
7
7.4
less then 7
Less then glargine
Half life of levemir is
5 to 7 hours depending on dose
5 to 9 hours depending on dose
7 to 9 hours depending on dose
Levemir approved in
129 countries
130 countries
145 countries
in every country
levemir use in Lactating MothersDose
Only glargine need adjustments
simply start with no adjustments required
adjustment is required
adapted from Heise T et al 2004 the levemir has a intra patient variability......% vs NPH ang glargine
48%
27%
68%
The name, detemir, is derived from this modification
Latin word
des threonine (B30) + myristic (mir) acid (B29).
des threonine (B29)+ myristic (mir) acid (B30)
according to UKPDS 1%reduction in HbA1c reduces the complications decreased Stroke chance
12%
37%
14%
21%
Characteristics of an Ideal Basal Insulin ,please ✅ the correct options
As “physiological” as possible
Limits weight gain
Long action profile
Minimal peak -Low variability
