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WorksheetsImmunology Wrap
Total questions: 20
Worksheet time: 10mins
With regards to acute inflammation, which one of the following processes normally occurs?
Local vasoconstriction
Decreased vascular permeability
Homing due to chemokine molecules
Leucocytes leave the tissues
Inhibition of histamine
Which of the following statements about the innate immune system is correct?
It is a specific response to a particular antigen
The response improves with repeated exposures
It is composed of phagocytes and complement
It is good at combating intracellular pathogens
It takes a long time to develop
Most extracellular bacteria are killed by which immunological cells?
Cytotoxic CD8 T cells
The membrane attack complex (MAC)
CD4 T helper cells
Natural Killer cells
Phagocytes
What process do phagocytes use to kill pathogens?
Formation of the membrane attack complex
Death receptor signals which result in apoptosis
Antibody dependent cell cytotoxicity
Respiratory burst
Complement dependent cell cytotoxicity
Which resident tissue cell mediates the inflammatory response?
Neutrophil
Mast Cell
T Cell
B Cell
Fibroblast
Pathogen associated molecular patterns (PAMPs)
Allow T and B cells to recognise bacteria and destroy them
Are cysteine rich peptides that form channels in bacteria membranes
Are recognised by pattern recognition receptors of the innate immune system
Closely resemble host cell surface proteins and sugars
Induce secretion of interferons by virally infected host cells
Which one of the following cell types can induce apoptosis of virally modified cells?
Neutophils
Mast Cells
Eosinophils
Natural Killer Cells
B Cells
Which of the following is correct about the adaptive immune system?
CD8 T cells phagocytose cells
T cells produce antibodies
T helper cells are normally CD8 positive
CD4 positive T cells recognise antigen associated with MHC class II
The main function of plasma cells is to produce cytokines
Which of the following is true about the major histocompatibility complex (MHC)?
Class II MHC presents endogenous antigens
CD8 positive T cells bind class I MHC
Class I MHC is only present on antigen-presenting cells
Class I MHC presents peptides that are usually longer than class II MHC
The haplotype is found on chromosome 8
Which is the first class of antibody produced in response to a pathogen?
IgA
IgE
IgD
IgM
IgG
What is the name of the process whereby B cells can produce different types of immunoglobulin, with the same specificity?
Junctional diversity
Somatic hypermutation
Affinity maturation
Positive selection
Class switching
When thinking about an immune response to a virus, which is true?
Antibodies can neutralise virus particles, as well as act as an opsonin against virally infected cells
Interferon gamma acts on neighbouring cells by inhibiting transcription and translational of viral proteins
Viral peptides are presented on class II MHC molecules by infected cells
CD4 positive T cells are able to destroy infected cells
CD8 positive T cells help antibody production, as well as recruitment and activation of macrophages
The specific region of a pathogen that an antibody will bind to is called?
PAMP
TCR
Epitope
Paratope
Chemokine
Which Immune Cells can form memory cells?
Macrophages
B Cells
T Cells
Dendritic Cells
Neutrophils
When the body is first exposed to a pathogen, how many days does it take before antibodies and effector T cells are able to fight the infection?
0-3
4-6
7-10
11-14
15-18
A viral infection is usually fought by a cell mediated adaptive immune response using which cell type?
Mast Cells
CD8 cells (Cytotoxic T Lymphocytes)
Macrophages
Neutrophils
Fibroblasts
Which cell activates the CD8 T cell so that it can fight a viral infection?
T Helper 1 Cell
Macrophage
T Helper 2 Cell
Neutrophil
Mast Cell
What mechanism does a CD8 T cell use to kill virally infected cells?
Formation of the membrane attack complex
Death receptor signals which result in apoptosis
Antibody dependant cell cytotoxicity
Respiratory bursts
Complement dependent cell cytotoxicity
Virally infected cells produce which of the following to protect neighbouring cells?
TNF-α
IFN-α
IL-10
CXCL8
TGF-β
Once a dendritic cell has engulfed a pathogen, where does it usually travel to in order to present the antigen to a T cell?
Bone Marrow
Thymus
Local Lymph Node
Thyroid
Brain
