WorksheetsRA & Its Management
Total questions: 27
Worksheet time: 20mins
Which of the following structure is not associated with joint ?
Synovial membrane & Synovial Fluid
Cartilage
Bones
Immune complex
Rheumatoid arthritis (RA) is defined as---
Chronic inflammatory autoimmune disease.
Inflammatory disease of Hip & Knee joint
Acute Inflammatory disorder of smaller joint
Disease of the all major joints of body
RA factor, formed in Rheumatoid arthritis is also known as
IgG antibody
IgM antibody
IgE antibody
IgD antibody
Activated T cells produces cytokines like--
TNF alpha
INF gama
IL-1
All of the above
Formation of immune complex like IgG + IgM may lead to destruction of cartilage & Bony ankylosis
True
False
Synovitis is term used for--
Inflammation of cartilage
Inflammation of Synovial membrane
Inflammation of tendons
Inflammation of Capsule
Pannus formation means-
Pannus is an abnormal layer of blood vessel which covers cartilages
Pannus is covering of bone
Pannus is thickening of synovial membrane
Thickening of tendons and synovial fluid
Term bony ankylosis is used for
Fusion of bony ends
Fusion of ligaments
Fusion of Muscle & tendons
None of the above
Which of the following does not include in classification criteria for RA
Joint distribution
Serology ( RA factor & ACPA )
Symptoms duration & acute phase reactants
Fusion of the joint
The key objective to start the therapy of RA is--
Control pain & Inflammation
Minimize the joint damage
Improve or maintain physical function and QOL
All of the above
Which of the following drug belongs to corticosteroids
Piroxicam
Prednisolone
Methotrexate
Abatacept
Which of the following drug belongs to targeted synthetic DMARDs
Tofacitinib
Methotrexate
Leflunomide
Infliximab
Adalimumab, Infliximab & Etanercept belongs to class-
TNF alpha agonist
TNF alpha antagonist
IL-1 Antagonist
B cell depletory
Choose the correct option for MOA of Leflunomide
Activates the enzyme dihydroorotate dehydrogenase
Inhibits the enzyme dihydroorotate dehydrogenase to prevent synthesis of Nucleotides
Act as antagonist for T cell production
How to check efficacy of drug & improvement
ACR responses
Prognostic factor
Radiological Investigation
All of the above
If a patient is taking Leflunomide since last six month but his ESR & RA factor is high with increased no of swollen joint, this indicates---
Good prognosis
Poor prognosis
Moderate prognosis
As per the EULAR guidelines the newly detected RA patients should be started with therapy--
Methotrexate only
Leflunomide
Sulfasalazine
Methotrexate with the combination of glucocorticoids for short term
Leflunomide can be started as first line therapy in case of
Methotrexate is contraindicated or not tolerable
Methotrexate is not available
HCQS used but not shown responses
already used biological DMARDs but not responded
Dosage of Leflunomide is
100 mg BID loading dose for 3 days followed by 10-20 mg OD
100 mg OD loading dose for first 3 days followed by 10 or 20 mg OD as maintenance dose.
10 or 20 mg OD for first 4- 6 weeks followed by 100 mg OD for 3 days.
Leflunomide is contraindicated for ( Multiple answers)
Patients with impaired liver function
Patients with severe immunodeficiencies states
Patients with severe infections & Hypoproteinemia
Patients with active rheumatoid arthritis
The main theme of Lefutoid is
True fighter in Rheumatoid
Restore in rhythm in life
Instill self confidence
None
The Key USPs of Rymti is (Multiple option)
One step activation
Better cap grip
Longer safety guard for ease in self administration
Single click sound to ensure delivery
Rymti proven bio-similarity in (Multiple answers)
Efficacy- ACR 70 response rate
Safety- Better tolerability & Lower TEAE
Immunogenicity- Higher incidence of ADA binding
Immunogenicity- Lower incidence of ADA binding
Lefutoid helps in RA management by ( Multiple answers)
Inhibiting the structural damage
proven long term efficacy
Safe and well tolerated
available in 40 mg & 80 mg Tab
In Immunogenicity , ADA stands for-
American Diabetic Association
Anti Drug Antibody
Anti infective Drug
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