Font size
WorksheetsVirchow's Virtues
Total questions: 15
Worksheet time: 16mins
In 2013, Angelina Jolie announced that she had undergone prophylactic bilateral mastectomy due to a maternally inherited pathogenic mutation that caused an increased risk of developing breast cancer. What is INCORRECT about this particular gene?
It is a tumour suppressor gene
Tumours that are positive for this genetic mutation are triple negative tumors usually with a poor prognosis
The most common histological pattern associated with this mutation is papillary
It is present on chromosome 17
Splenic conditioning is a process mainly occurring in:
Thalassemia
Hereditary Spherocytosis
Sickle Cell Trait
Iron deficiency anemia
Hey folks, if he doesn’t respond to your texts, doesn’t comment on your pictures, is CD30+ve and CD15+ve, is binucleate and looks like this, he is not your man, but is a:
A man presents with recurring renal stones. This was found to be calcium stones. What is the most likely underlying disorder?
Anemia of chronic disease
Factor VIII deficiency
Hyperaldosteronism
Hyperparathyroidism
Which of the following are features of Crohn’s disease?
1. Usually transmural inflammation
2. Any portion of GIT can be involved but most commonly it occurs in the terminal ileum
3. Cobblestone appearance on gross morphology is characteristic
4. Caseating granulomas are seen
1,2,3
1,3,4
2,3,4
1,2,3,4
The picture below shows a trade route X that linked the West to the Middle East and Asia since 130 BC. An auto-immune disease Y which is characterized by a triad of oral, ocular, and genital lesions is prevalent almost exclusively among populations along the same route. Identify X and Y.
Senile Amyloidosis is due to:
Accumulation of wild type Transthyretin
Accumulation of mutated Transthyretin
Decreased levels of Transthyretin
Normal levels of mutated Transthyretin
Identify the disease from the pictures given below:
A woman presents to the OPD with exertional dyspnoea and easy fatigability. On physical examination, her gait is unstable when her eyes are closed, and has impaired vibratory sense. Further examination can include which one of the following tests?
Erythrocyte glucose-6-phosphatase
Erythrocyte pyruvate kinase
Serum methylmalonic acid
Serum protoporphyrin level
Identify this giant cell found in a patient's bone marrow aspirate:
Identify the option which contains the correctly matched pair of features:
Sarcoidosis - caseating granulomas
Silicosis - upper lobe predominant
Small cell carcinoma of lung - Azzopardi effect
Adenocarcinoma of lung - salt and pepper chromatin appearance
A 44-year-old woman presented with recurrent bruising, menorrhagia, fever, night sweating, and weight loss. On examination, the patient had splenic enlargement 6 cm below the left costal margin. Complete blood count and differential showed the following :
Haemoglobin - 5.4 g/dl
White blood cell - 2500 cells/μl
Red blood cell - 1,85,000 cells/μl
Platelets - 50,000 cells/μl
Neutropenia was also noted.
The PBS of the patient is shown below. Identify the most probable hematological abnormality from it.
Which of the following statements is/are correct?
The major cytokine involved in fibrosis is TGF-beta.
Stellate cells are the major collagen producers in liver cirrhosis.
The expression of selectins is induced by IL-1.
All of the above.
Identify this tumour:
Autopsy diagnosis of MI can be done by immersion of tissue in :
Masson's Trichrome
Triphenyl Tetrazolium Chloride
Crystal Violet
Alcian Blue
