WorksheetsMedical Micro 7: Urinary and Reproductive
Total questions: 87
Worksheet time: 51mins
Function of the urinary system:
maintain fluid levels in our body
ensure survival of the species
delivers oxygen, nutrients, hormones, and other important substances to cells and organs in the body
removes waste products from the blood and helps maintain homeostasis
Who is more at risk of developing a UTI and why?
Males - microflora more easily move to male urethra because the distance is much shorter
Males - microflora more easily move to male urethra because the distance is much longer
Females - microflora more easily move to male urethra because the distance is much shorter
Females - microflora more easily move to male urethra because the distance is much longer
Primary sex organs of the male reproductive system:
testes
epididymus
vas deferens
seminal vesicle
prostate
Secondary sex organs of the male reproductive system:
testes
epididymus
vas deferens
seminal vesicle
prostate
External sex organs of the male reproductive system:
testes
scrotum
penis
Primary sex organs of the female reproductive system:
ovaries
fallopian tubes
uterus
vagina
vulva
Secondary sex organs of the female reproductive system:
cervix
fallopian tubes
uterus
vagina
vulva
Normally sterile
kidneys
bladder
ureters
distal region of the female urethra
May be colonized by a variety of bacterial species
kidneys
bladder
ureters
distal region of the female urethra
Main resident bacteria of the male and female urethra (HINT: main skin microbiota):
Corynebacterium
Streptococcus
Staphylococcus
Bacteroides
Prevotella
Lesser degree of microbiota in the male and female urethra:
Corynebacterium
Streptococcus
Peptostreptococcus
Prevotella
Porphyromonas
_____'s urethra is about five times shorter, hence ascending infections into the bladder and kidneys are more frequent
Male
Female
________ species thrive in the acidic pH of the vagina. They convert sugars to lactic acid which further contributes to the low pH.
Streptococcus
Staphylococcus
Bacteroides
Lactobacillus
________ microbiome is susceptible to significant alterations (dysbiosis) that lead to several common infections
Vagina
Vulva
Penis
Scrotum
Urethra
Most common cause of UTIs
S. pyogenes
S. agalactiae
E. coli
Urinary Tract Infections (UTIs) are characterized by the presence of a significant number of bacteria in the urinary tract.
True
False
involve the urethra, bladder, prostate:
Infections of the lower respiratory tract
Infections of the upper respiratory tract
Involve the kidneys
Infections of the lower respiratory tract
Infections of the upper respiratory tract
inflammation of the urethra
urethritis
cystitis
prostatitis
pyelonephritis
bacteria from the lower intestine and anus reach the vagina
urethritis
cystitis
prostatitis
pyelonephritis
Urethritis commonly caused by:
Neisseria meningitidis
Streptococcus pneumonia
Listeria Monocytogenes
Neisseria gonorrhoeae
Chylamydia
infection of the bladder
urethritis
cystitis
prostatitis
pyelonephritis
More common in women:
urethritis
cystitis
prostatitis
pyelonephritis
inflammation and infection of the prostate (men only)
urethritis
cystitis
prostatitis
pyelonephritis
A UTI involving one or both kidneys
urethritis
cystitis
prostatitis
pyelonephritis
back pain common symptom
urethritis
cystitis
prostatitis
pyelonephritis
can lead to permanent damage of the kidneys or spread systemically (sepsis)
urethritis
cystitis
prostatitis
pyelonephritis
Prostatitis can be classified into:
acute bacterial prostatitis
acute viral prostatitis
chronic bacterial prostatitis
chronic viral prostatitis
latent prostatitis
urethritis, cystitis, and prostatitis:
Infections of the lower urinary tract
Infections of the upper urinary tract
pyelonephritis
Infections of the lower urinary tract
Infections of the upper urinary tract
zoonotic disease affecting the kidneys and other tissues
urethritis
cystitis
prostatitis
pyelonephritis
leptospirosis
Causative agent of Leptospirosis:
Neisseria meningitidis
Leptospira interrogans
Streptococcus pneumonia
Listeria Monocytogenes
Neisseria gonorrhoeae
Thin, aerobic, gram-negative, motile spirochete; hook at one end resembles a question (hence the name)
Neisseria meningitidis
Leptospira interrogans
Streptococcus pneumonia
Listeria Monocytogenes
Neisseria gonorrhoeae
Enters host through mucous membranes of eyes, nose, and mouth, or through abrasions on the feet
urethritis
cystitis
prostatitis
pyelonephritis
leptospirosis
Severe form of leptospirosis - meningitis, liver, lung, and kidney damage
Weil syndrome
Guille syndrome
Leptospirosis syndrome
Renal syndrome
Treatment for leptospirosis:
Amoxicillin
Doxycycline
Penicillin
Causative agent of Bacterial Vaginosis:
G. vaginalis rods
C. abicans
Causative agent of Vaginal Candidiasis:
G. vaginalis rods
C. abicans
Most common vaginal infection in women of child-bearing age
Bacterial vaginosis
Vaginal candidiasis
Bacterial Vaginosis shows a decreased number or absence of
Lactobacilli
Gardnerella vaginalis
Prevotella
Mobiluncus
Bacterial vaginosis shows an increase in:
Lactobacilli
Gardnerella vaginalis
Prevotella
Mobiluncus
KEY CHANGES in Bacterial Vaginosis
Dysbosis
Production of volatile amines
pH > 4.5
white thick discharge
Treatment options for Bacterial vaginosis:
oral or topical metronidazole
oral or topical clindamycin
topical nystatin
topical clotrimazole
oral fluconazole
Treatment options for Vaginal Candidiasis
oral or topical metronidazole
oral or topical clindamycin
topical nystatin
topical clotrimazole
oral fluconazole
Vaginal candidiasis is caused by a naturally occurring fungus of the vaginal microbiota
True
False
Specific symptoms include itching and a white thick discharge, because it is an inflammation:
Bacterial vaginosis
Vaginal candidiasis
Preventing Pelvic Inflammatory Disease (PID) is a primary reason for treating these STDs, especially in women.
True
False
Most frequently reported STD
Chlamydia
Gonorrhea
Pelvic inflammatory disease
One of several diseases known as non-gonococcal urethritis (NGU)
Chlamydia
Gonorrhea
Pelvic inflammatory disease
C. trachomatis:
is obligate
is an intracellular parasite
is an extracellular parasite
life cycle has 2 phases
life cycle has 4 phases
Life cycle phase of C. trachomatis that is non-replicating, extracellular, and infectious:
Elementary Body (EB)
Reticulate Body (RB)
Life cycle phase of C. trachomatis that is replicating, intracellular, non-infectious:
Elementary Body (EB)
Reticulate Body (RB)
silent disease; 85-90% of infected individuals are asymptomatic
Chlamydia
Gonorrhea
Pelvic inflammatory disease
Transmission: sexual contact or newborn during birth
Chlamydia
Gonorrhea
Pelvic inflammatory disease
Treatment for chlamydia
Tetracyclines (doxycycline)
Macrolides (azithromycin)
Steroids (prednisone)
Neisseria gonorrhoeae:
gram-negative
gram-positive
diplococcus
rods
nonencapsulated, nonmotile
This disease has antibiotic resistance so treatment is high dose ceftriaxone IM x 1 dose:
Chlamydia
Gonorrhea
Pelvic inflammatory disease
In females, gonorrhea can spread to the fallopian tubes and cause:
pelvic inflammatory disease (PID)
possible sterility
ectopic pregnancy
salpingitis
gonococcal ophthalmia
Possible causative agents of Pelvic Inflammatory Disease (PID):
Neisseria gonorrhoeae
Chlamydia trachomatis
Lactobacillus
anaerobes
aerobes
infection of uterine tubes
cystitis
prostatitis
pyelonephritis
salpingitis
Symptom: chronic abdominal pain (pain during or after menses is particularly suggestive)
cystitis
prostatitis
pyelonephritis
salpingitis
Syphilis is caused by _________, a spirochete for which humans are the only host.
Neisseria gonorrhoeae
Chlamydia trachomatis
Treponema palladium
Lactobacillus
Diagnosis to syphilis includes:
observation of spirochetes by microscopy
gram staining
blood count
rapid plasma regain (RPR)
T. pallidum enzyme immunoassay (TP-EIA)
characterized by a lesion (chancre) where the bacteria entered the body
primary syphilis
secondary syphilis
chronic latent stage
tertiary syphilis
congenital syphilis
occurs when the spirochete spreads through the blood and lymph to other body organs
primary syphilis
secondary syphilis
chronic late stage
tertiary
congenital
Sores (chancres) in _______ syphilis are ________.
primary and secondary; infectious
primary and secondary; non-infectious
tertiary; infectious
tertiary; non-infectious
3-30 years follows in which relapses of secondary syphilis occur (infectious at this point)
primary syphilis
secondary syphilis
chronic late stage
tertiary syphilis
congenital syphilis
involves formation of gummas that can cause weakening/bursting of blood vessels, degeneration of spinal cord tissues, brain damage leading to personality and judgment changes and insanity:
primary syphilis
secondary syphilis
late chronic stage
tertiary syphilis
congenital syphilis
Gumma in ____________ syphilis are _______.
primary and secondary; infectious
primary and secondary; non-infectious
tertiary; infectious
tertiary; non-infectious
can occur in the fetus of a pregnant woman, leading to stillbirth or Hutchinson's triad:
primary syphilis
secondary syphilis
late chronic stage
tertiary syphilis
congenital syphilis
Hutchinson's traid includes:
deafness
blindness
impaired vision
notched, peg-shaped teeth
small upper lip
Treatment of syphilis:
Benzathine Penicillin G 2.4 million units IM x 1 dose
Benzathine Penicillin G 2.4 million units IM x 3 doses separated by 1 week
Aqueous Penicillin G 20 million units IV continuous infusion daily x 10 days
Aqueous Penicillin G 24 million units IM daily x 3 doses
cold sores
HSV-1
HSV-2
infection of the genitals
HSV-1
HSV-2
Signs of primary infection of herpes viruses
Itching or throbbing in the genital area
Reddening and appearance of blisters
Blisters crust over and disappear after 3 weeks
Skin rash
Swollen lymph nodes
HSV-2 can go into latency and recur
True
False
HPV can predispose people to cancer
True
False
Frothy, greenish vaginal discharge with a "musty" malodorous smell is characteristic:
HSV-1
HSV-2
HPV
Trichomoniasis
Transmission usually occurs via direct, skin-to-skin contact with an infected individual, most often through vaginal discourse:
HPV
Trichomoniasis
Parasitic protozoan, exists in only one morphological stages, causes this disease:
HPV
Trichomoniasis
Vaccine for HPV that works against multiple serotypes
DTaP
Shingrix
Menevo
Gardasil 9
Transmitted via oral, vaginal, or anal sex
HPV
Trichomoniasis
Genital warts (condylomata) are caused primarily by
HPV 6
HPV 11
HPV 16
HPV 18
HPV types _____ cause 70% of cervical cancer
6
11
16
18
HPV serotypes are also associated with cancer of the _____
anus
vagina/vulva
penis
mouth/throat
cervical
How would scarring lead to infertility?
Scarring increases the risk of contracting gonorrhea
Scarring can block the fallopian tubes and result in infertility or an ectopic pregnancy
Scarring allows bacteria of the normal flora to adhered to fallopian tubes and results in atrophy of the tubes
What are inclusion bodies?
Structures within the bacteria that are useful in diagnosis of the infection
Invaginations of the fallopian tube mucosa caused by Chlamydia infection
The structure within which the development cycle of Chlamydia occurs
