WorksheetsHEMATOLOGY 1
Total questions: 30
Worksheet time: 19mins
A membrane-associated ecto-adenosine diphosphatase (ADPase) found on surface of endothelial cells that degrades ADP released from activated platelets.
CD41
ADAMST13
CD39
ADAMTS13
Critical enzyme/s in the biosynthesis of thromboxane A2 which is/are irreversibly actylated by aspirin.
COX-1
COX-2
COX 1 and 2
VWF
The ADP receptor antagonists include the thienopyridines (clopidogrel and prasugrel) as well as ticagrelor and cangrelor. All of these drugs target the key ADP receptor on platelets called ______.
ADAMTS13
ADAMST13
P2Y2
P2Y12
VWF
It is an orally active inhibitor of P2Y12, this drug differs from the thienopyridines in tha it does not require metabolic activation and it produces reversible inhibition of the ADP receptor.
DIPYRIDIMOLE
CLOPIDOGREL
TICAGRELOR
CANGRELOR
It is a relatively weak antiplatelet agent on its own, but an extended-release formulation of this drug combined with low-dose aspirin, a preparation known as Aggrenox, is used for prevention of stroke in patients with transient ischemic attacks.
CANGRELOR
PRASUGREL
DIPYRIDAMOLE
CLOPIDOGREL
It is an orally active PAR-1 antagonist, which is slowly eliminated with a half-life of about 200 h.
tirofiban
vorapaxar
eptifibatide
abciximab
GP IIB/IIIA RECEPTOR ANTAGONISTS
abciximab
eptifibatide
tirofiban
vorapaxar
Heparin-induced thrombocytopenia (HIT) is an antibody-mediated process that is triggered by antibodies directed against neoantigens on _________ that are exposed when heparin binds to this protein
PF1
PF2
PF3
PF4
Thrombocytopenia in HIT should be suspected when.....
Platelet count of ≤100,000/μL
decrease in platelet count of ≥50% from pretreatment level
both
only suspected clinically
In HIT, platelet count usually falls how many days after starting heparin?
1-3 days
3-6 days
5-10 days
1-2 weeks
Heparin-associated osteoporosis is expected if treatment is
>4 months
>3 months
>2 months
> 1month
A synthetic analogue of the antithrombin-binding pentasaccharide sequence and is licensed for thromboprophylaxis in general medical or surgical patients and in high-risk orthopedic patients and as an alternative to heparin or LMWH for initial treatment of patients with established venous thromboembolism.
Enoxaparin
Fondaparinux
Bivalirudin
Argatroban
Warfarin has a narrow therapeutic window, frequent coagulation monitoring is essential to ensure that a therapeutic anticoagulant response is maintained. Even patients with stable warfarin dose requirements should have their INR determined every__________ weeks.
1-2
2-3
3-4
4-6
Warfarin is administered in doses that produce a target INR of 2.0–3.0. An exception is patients with mechanical heart valves, particularly those in the mitral position or older ball and cage valves in the aortic position, where a target INR of ______________ is recommended.
2-4
2.5-3.5
3-4
3.5-4.5
It is a two-chain serine protease derived from cultured fetal kidney cells with a molecular weight of 34,000. This drug converts plasminogen to plasmin directly by cleaving the Arg560-Val561 bond.
Alteplase
Urokinase
Tenecteplase
Streptokinase
It is a single-chain, recombinant tPA derivative that lacks the finger, epidermal growth factor, and first kringle domains. This truncated derivative has a molecular weight of 39,000. Reteplase binds fibrin more weakly than tPA because it lacks the finger domain. It is produced in Escherichia coli.
Reteplase
Tenecteplase
Streptokinase
Alteplase
It is a genetically engineered variant of tPA and was designed to have a longer half-life than tPA and to be resistant to inactivation by PAI-1.
Alteplase
Tenecteplase
Urokinase
Streptokinase
Warfarin does not pass into the breast milk. Consequently, warfarin can safely be given to nursing mothers.
TRUE
FALSE
A common complication of warfarin, skin necrosis usually is seen 2–5 days after initiation of therapy
TRUE
FALSE
The risk of embryopathy is highest if warfarin is given in the second trimester of pregnancy
TRUE
FALSE
Factor II is also known as
(a)
To calculate the INR, the patient’s prothrombin time is divided by the mean normal prothrombin time, and this ratio is then multiplied by the ISI( ranging from 0.9 to 1.4). ISI stands for...
(a)
The key ADP receptor on platelets targeted by thienopyridines (clopidogrel and parugrel).
(a)
Most widely used antiplatelet agent worldwide
(a)
It is the most abundant receptor on the platelet surface, undergoes a conformational change that enables it to bind fibrinogen and, under high shear conditions, VWF
(a)
GP IIB/IIIA RECEPTOR ANTAGONISTS
abciximab
tirofiban
eptifibatide
all oif the above
Before a major surgery, clopidogrel and prasugrel must be stopped at least how many days?
(a)
A synthetic 20-amino-acid analogue of hirudin, s a divalent thrombin inhibitor.
It is licensed as an alternative to heparin in patients undergoing percutaneous coronary intervention. This drug was also has been used successfully in HIT patients who require percutaneous coronary intervention or cardiac bypass surgery.
(a)
In HIT arterial thrombosis is more common than venous thrombosis.
True
False
Fondaparinux does not cause HIT because it does not bind to PF4.
True
False
