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DERM/MSK- NSAID intro and pathophysiology

Total questions: 33

Worksheet time: 20mins

Name
Class
Date
1.

What are signs inflammation?

a)

Itching

b)

Redness

c)

Swelling

d)

Heat

e)

Pain

2.

What is considered acute inflammation?

a)

Long term inflammation that may cause lasting damage over time

b)

Prolonged variable inflammation

c)

Inflammation that tends to be local, more severe and less than 2 weeks in duration

d)

Inflammation that tends to be diffuse

3.

Which of the following is NOT true?

a)

Inflammation is the body's response to injury, pathogen, or necrosis

b)

Inflammation is meant to destroy the invader and repair damage

c)

Inflammation can lead to tissue damage

d)

Inflammation is only classified as chronic

4.

Which of the following are produced through degranulation?

a)

Prostaglandins and Leukotrienes

b)

Serotonin and Proteases

c)

Platelet Activation Factor

d)

Histamine and Heparin

5.

Which of the following are membrane-derived lipid mediators?

a)

Prostaglandins and Leukotrienes

b)

Platelet Activation Factor

c)

Histamine and Serotnin

d)

Proteases and Heparin

6.

True or False. PGs are sensitizing agents that have a synergist role with other inflammatory mediators.

a)

True

b)

False

7.

PGs play a regulatory function in all of the following except

a)

Smooth muscle contraction

b)

Bronchodilation

c)

Platelet activation/aggregation

d)

Kidney function

e)

Heart rate

8.

AA is synthesized from dietary linoleic acid and stored

a)

by esterification to membrane phospholipids

b)

by oxidation of transmembrane proteins

c)

by esterification to cyclooxygenase

d)

by reduction of amino acids

9.

Which enzyme frees arachidonic acid?

a)

CYP2E1

b)

Phospholipase A2

c)

Cyclooxygenase

d)

Lipoxygenase

10.

Select all that apply. Cyclooxygenase

a)

contains heme

b)

is not membrane bound

c)

is involved in prostacyclin, thromboxane and prostaglandin synthesis

d)

has 3 major isozymes

11.

Which enzyme is responsible for "housekeeping" ?

a)

COX-1

b)

COX-2

c)

LOX

12.

COX-2 is responsible for

a)

renal adaptation to stress

b)

spongy bone hemostasis

c)

ovulation and uterine contractions

d)

pain, fever, and inflammation

e)

platelet function

13.

Which prostaglandins (PGs) mediate inflammation?

a)

E

b)

I

c)

D

d)

F

14.

Prostaglandins

a)

are 20 carbon fatty acids

b)

are 16 carbon fatty acids

c)

have a 15-hydroxyl group

d)

have a cyclopentane ring

e)

have 17-hydroxyl group

15.

Thromboxane and prostacyclin are

a)

competitive antagonists

b)

physiological antagonists

c)

uncompetitive antagonist

d)

physiological agonists

16.

Thromboxane

a)

is synthesized from PGH2 and is associated with vasoconstriction and platelet adhesion/aggregation

b)

is synthesized from PGH2 and is associated with vasodilation and inhibits platelet aggregation

17.

Prostacyclin

a)

synthesized from PGH2

b)

vascular endothelium

c)

vasodilation

d)

inhibits platelet aggregation

e)

vasoconstriction

18.

Prostaglandin receptors

a)

bind mostly to multiple GPCRs with varied effects

b)

bind mostly to a specific GPCR with a specific effect

19.

PGE2 is involved in

a)

pain

b)

inflammation

c)

fever

20.

PGI2 is involved in

a)

pain

b)

inflammation

c)

fever

21.

PGE2 is synthesized in vasculature of hypothalamus in response to

(a)  

22.

NSAIDs are commonly used for

a)

inflammation, pain and fever

b)

cough and cold

c)

allergies

d)

digestive aids

23.

True or False. ALL NSAIDs act as reversible, competitive COX inhibitors.

a)

True

b)

False

24.

True or False. NSAIDs block the hydrophilic channel where arachidonic acid normally binds.

a)

True.

b)

False.

25.

Boxed warnings for NSAIDs apply to

a)

aspirin

b)

ketorolac

c)

ibuprofen

d)

acetaminophen

e)

meloxicam

26.

NSAID boxed warnings

a)

Serious gastrointestinal bleeding, ulcerations, and perforation

b)

Serious cardiovascular thrombotic events

c)

Serious skin reactions

d)

Increased risk of tendon rupture

27.

Fluid retention/edema, chronic toxicity, dizziness, rash and hypersensitivity are examples of

a)

NSAID general adverse reactions

b)

NSAID boxed warnings

28.

Which enzyme is the major enzyme in the GIT?

a)

COX-1

b)

COX-2

c)

CYPE21

d)

LOX

29.

Which PG maintains ductus arteriosus in a fetus?

a)

PGI2

b)

PGE2

30.

PGE2 acts on tubules which decreases Na+ reabsorption and increase urinary output.

a)

True

b)

False

31.

Which of the following is not an affect of PGE2 on glomeruli?

a)

decreased Na+ reabsorption

b)

increased arteriole dilation

c)

increased renal perfusion

d)

increased filtration

e)

increased urinary output

32.

NSAIDs should be avoided in pregnancy.

a)

True

b)

False

33.

NSAID hypersensitivity can lead to

a)

rhinitis

b)

urticaria

c)

bronchoconstriction

d)

anaphylaxis

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