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WorksheetsAntifungal drugs
Total questions: 27
Worksheet time: 18mins
There are few agents because of similarities between eukaryotic fungal cells and human cells
TRUE
FALSE
Polyenes bind to
(a)
Azoles inhibit ergosterol
(a)
To treat a mycoses a combination of drugs may be used, these include;
polyenes
antibiotics
azoles
a drug that inhibits nucleic acid/protein synthesis/cell division
a drug that disrupts RNA function
Topical forms of azole drugs treat
Superficial mycoses
Cutaneous Mycoses
Systemic Mycoses
Superficial and cutaneous are limited to
Hair
Internal Organs
Skin
Cells
Superficial mycoses of the nails are treated with
Amphotericin B
Nystatin
Griseofulvin
Fluconazole
Griseofulvin
binds to ergosterols
disrupts fungal mitotic spindles therefore preventing cell division
Inhibit ergosterol synthesis
drug that disrupts RNA function
Nystatin a polyene is used to control opportunistic
Candida
Tinea Versicolor
P.jiroveci
Malaria
Nystatin can be taken systemically
TRUE
FALSE
Which drugs are commonly used to treat systemic mycoses?
Amphotericin B
Nystatin
5-flucytosine
Fluconazole
What antifungal drug is this?
nystatin
amphotericin b
fluconazole
5-flucytosine
5-flucytosine
Inhibits nucleic acid synthesis
Disrupts RNA function
Inhibits ergosterol biosynthesis
Disrupts cell division
Fungal microbes don't develop drug resistance to 5-flucytosine
TRUE
FALSE
The two drugs paired up to treat cryptococcal meningitis are;
Fluconazole
5-flucytosine
Nystatin
Amphotericin B
5-flucytosine is converted to 5FU only by fungi. 5FU is an analogue for;
Uracil
Thymine
Adenine
Guanine
Fluconazole is used prophylactically to treat patients who are
(a)
Azoles and polyenes are ineffective against P.jiroveci because its membranes contain
glycoproteins
cholesterol
ergosterol
fatty acids
P.jiroveci is treated with
antiprotozoal drugs
antibiotics
antimetabolite drugs
antiviral drugs
Antibiotics promote yeast infections
TRUE
FALSE
Men are more susceptible to genital yeast infections
True
False
What is fluconazole's mechanism of action?
Disrupts RNA function
Inhibits enzyme lanosterol 14-alpha demethylase
depletes ergosterol in the cell membrane and accumulates toxic intermediate sterols
binds with ergosterol forming pores that cause rapid leakage of monovalent ions
causes increased membrane permeability and inhibition of fungal growth
What sterol results from this synthesis?
cholesterol
ergosterol
sitosterol
What monovalent ions leak out of the cells as a result of amphotericin b binding with ergosterol?
Li, K, Cl, I
K, H, Cl, Na
K, Na, F, Cl
Na, F, I, H
Cholesterol is more sensitive to Amphotericin B than ergosterol
TRUE
FALSE
What antifungal drug is this
(a)
Which sterols do bacteria have in their membranes?
Ergosterol
Cholesterol
None of the above
