Study that concern itself with the physical, chemical and biological factors which influenced the formulation, manufacture, stability and effectiveness of pharmaceutical dosage forms

Generally, pharmaceutics deals with the formulation of new drug substances into the dosage form, from raw or starting materials to the finish product.

Extemporaneous preparations are compounded by the pharmacists for specific patients because some drugs are readily available in the market

Function of Pharmaceutical Ingredients EXCEPT

Contaminants promote bacterial growth. Hence, patient can use contaminated products

Steps in Compounding EXCEPT

Compounding and cleaning is mandatory in clearance

Signing and dating the prescription affirms that all of the indicated procedures were carried out to ensure:

I. uniformity, identity, strength, quantity, purity

II. clean

III. validation from health authority

Prevent tablet ingredients from sticking to punches and dies during production

Uses of tablet coating agent

A thin cover around a formed tablet or bead

Used in tablet and capsule formulations to improve flow properties of the powder mixture

Opaquant may be used alone or with a colorant in tablet and capsule

Used to impart an attractive sheen to coated tablets

Used to form thin shells to enclose a drug for ease of administration. Ex. Gelatin

Used to prevent drying of preparations, particularly ointments and creams

Used to increase thickness or hardness of a preparation, usually an ointment

Used to resist change in pH upon dilution or addition of acid or alkali

Substance that forms stable water-soluble complexes (chelates) with metals; used in some liquid pharmaceuticals as stabilizers to complex heavy metals that might promote instability.

Containers according to their ability to protect the contents from external conditions EXCEPT

protects the contents from other solids and from loss of the article under normal

It protects the contents from contamination by extraneous liquids, solids or vapors, from loss of the article and from efflorescence

phenomena where the water of crystallization of substance evaporates upon exposure to dry environment

USP standard on limit if light transmission

A child resistant container that is significantly difficult for children under 8 years of age to open

alerts the consumers of foul play or damage to the product

Example of Tamper Evident Containers EXCEPT

Parenteral preparation does not require to meet the antimicrobial effectiveness requirement because it is for single dose only

EXAMPLES OF SINGLE DOSE CONTAINER EXCEPT

Multiple dose container usually expires in 28 days when opened unless there is indication in the container

Parenteral products only EXCEPT

rigid and has good clarity; useful in blister packaging of

tablets and capsules. Not suitable when gamma sterilization is required

____ and _____ have excellent transparency and luster can be sterilized with gamma radiation

Plastic squeeze bottles are common in ophthalmic and otic preparations

Used for dispensing liquids of low viscosity

According to federal regulations, manufacturers' drug product labeling includes:

Label of Supplement Facts includes:

USP product standardization program is mandatory participation

STORAGE CONDITIONS: COLD

STORAGE CONDITIONS: COOL

Tablets and Capsules shelf life is minimum of 5 years the date of preparation

example of oral use EXCEPT

Nitrogylcerin tablet triturate is intended to be dissolved or taken in the buccal pouch.

Used by doctors in extemporaneous preparation of parenteral solutions

Molded tablets are generally prepared by mixing the active drug with lactose, dextrose, sucrose, mannitol, or some other appropriate diluent that can serve as the base.

SYNONYMS OF TABLET TRITURATES

less than 20 mg (potent substance with cooling agents)

20 mg to 60 mg (contains sugar)

The standard moisture content specification for hard gelatin capsules.

Clindamycin hydrochloride

gelatin derived from pork skin by acid processing

gelatin obtained from bones and animal skins by alkaline processing

sifting is acceptable for theincorporation of potent drugs into a diluent powder

- Moisture-activated adherent

- An ethylene oxide polymer with a high molecular weight

- Forms a viscous, mucoadhesive gel

Commercial antibiotic products

Commercial probiotic products

suppository that is globular, oviform and cone shape

Migraine

NSAID

PSYCHOLOGICAL FACTORS EXCEPT

PHYSIOCHEMICAL FACTORS EXCEPT

Rectal fluids are not essentially neutral in pH andhave effective buffer capacity.

- triglycerides of saturated fatty acids

- came from lauric acid

STIFFENING AGENT FOR GLYCERIN SUPP

When tartaric acid (only) is added to Na phosphate effervescent granules, powder will be crumble and if citric acid only, it will result to sticky

DRY OR FUSION METHOD: The ____ acts as the binding agent

Synonyms of ointments

Moistening agent in the preparation of tablet

This is added in soft gelatin capsule formation to ensure adequate flexibility

- most ingredients used in ointment bases will liquefy around __ degree Celsius

Accelerate the cooling process by putting the melt in water or ice. This will not change the consistency of the final product making it more viscous than desired.

Uses fusion method EXCEPT

It is added to reduce the penetration of light into the capsule to protect photosensitive drug

It is cylindrical in shape and tapered at one end or both forming a bullet shape end.

In this process, the powder is pressed between rollers to increase density of a powder.

This method is not applicable for moisture sensitive powders

It is the acidifier in the formulation of Sodium Phosphate effervescent granules

USES OF ZINC OXIDE PASTE

preservative In cold cream

greaseless bases

Medicated ointment uses EXCEPT

Stiffening agent of Glycerol suppositories

TYPES OF STABILITY: Physical

Dietary products may not have a disclaimer statement

In this method, the powder is dissolved in volatile solvent. Then the powder re-crystallizes after the solvent evaporates.

Official room temperature

used as a preservative in pills and might be omitted if only a small batch of pill mass was being compounded.

best used on dry skin.

in applying ointment. inunction is required

Latin name of ZnO paste

vehicle of ZnO paste

Paste: because of their low powder content, they are often used to absorb wound exudates

used to remove warts, calluses, or other lesions in which the epidermis produces excess skin

Incorporation of a gummy material via pulverization by intervention

formerly, the pills are the most extensive used oral dosage form, but it is replaced by compressed tablets and capsules