WorksheetsSession II: Epigenetic Regulation and Metabolism Interplay
Total questions: 10
Worksheet time: 6mins
Isocitrate dehydrogenase 1 (IDH1) is rarely found mutated in distinct tumor types.
FALSE
TRUE
IDH1/2 mutation is one of the most frequent alterations involved in the development of extrahepatic cholangiocacinoma
TRUE
FALSE
In genetically engineered mouse models, mIDH1 can drive the growth of cholangiocarcinoma via the paracrine regulation of anti-tumor immunity and cell-autonomous epigenetic reprogramming
FALSE
TRUE
What type of response does AG120 treatment induce ?
interferon alpha
interferon beta
interferon gamma
A combined therapy of AG120 and anti-CTLA-4 inhibits tumor growth and protects mice from tumor recurrence.
TRUE
FALSE
Hypoxia Inducible Factor (HIF) transcription factors are activated in hypoxia via activation of prolyl hydroxylases (PHDs)
TRUE
FALSE
In in vitro human cancer cell studies, acute and prolonged hypoxia impact promoter accessibility at subsets of hypoxia driven genes and chromatin structure
FALSE
TRUE
Which processes can change chromatin state ?
Post-translational modification of histone tails
Histone dimer eviction and histone variant incorporation
Lipids oxidation
ATP-dependent chromatin remodelling
Hypoxia induces a redistribution of H3K4me3, specifically at promoter sites.
TRUE
FALSE
Which JmjC enzymes are responsible for the redistribution of H3K4me3 ?
KDM5 isoforms
PHD isoforms
KDM6 isoforms
