Font size
WorksheetsOncology
Total questions: 24
Worksheet time: 27mins
(Letrozole) Dracenax is also indicated for triple positive postmenopausal breast cancer.
True
False
Dracenax is indicated only for early postmenopausal HR positive breast cancer.
True
False
Dracenax contains __ mg of Letrozole.
25mg
10mg
2.5mg
5mg
What is the shelf life of Dracenax?
24 months
18 months
36 months
60 months
Dracenax is a (a) type of aromatase inhibitor
Dracenax is contraindicated to the following except for one.
Patients with known hypersensitivity to or any Dracenax of its excipients
Pregnancy and lactation
Patients with severe hepatic impairment (Child-Pugh grade C)
Women of postmenopausal endocrine status
These are the most frequently reported adverse reactions of patients taking Dracenax.
hot flushes
arthralgia
bone pain
all of the above
There is no dosage adjustment recommended for mild to moderate hepatic impairment for patients taking Dracenax.
True
False
Where is Dracenax manufactured?
Stein, Switzerland
Berleben, Germany
Kundel, Austria
Dracenax has demonstrated efficacy in patients with hormone receptor negative breast cancer.
True
False
There is no clinical experience to date on the use of Dracenax in combination of other anti-cancer agents.
True
False
Dracenax can be used in which line of breast cancer treatment?
Adjuvant treatment
Extended adjuvant treatment
First line treatment in advanced breast cancer
Second line treatment in advanced breast cancer
All of the above
Dracenax inhibits the aromatase enzyme by competitively binding to the hem of the aromatase cytochrome P450, resulting in the rapid increase of estrogen biosynthesis in all tissues where present.
True
False
Letrozole significantly reduced the overall risk of recurrence versus tamoxifen by how many percent in early breast cancer?
18%
19%
20%
25%
What are the 2 landmark trials of Letrozole?
(a)
Encircle the options on the use of Letrozole in breast cancer.
Upfront Letrozole for 5 years
Upfront Letrozole for 3 years
Tamoxifen for 2 year followed by Letrozole for 5 years
Tamoxifen for 5 years followed by Letrozole for 5 years
Upfront Letrozole for 10 years
Letrozole reduced the overall recurrence by __% regardless of nodal status/prior chemotherapy in the extended adjuvant setting.
45%
56%
42%
40%
Letrozole significantly reduced the risk of distant metastasis versus tamoxifen by how many percent in early breast cancer?
30%
27%
28%
35%
___ is a multinational, phase 3, randomized, double blind, clinical trial conducted in more than 8,000 patients.
TEAM
IES
ARNO
BIG 1-98
In the ___ study, patients with early-stage breast cancer receive 5 years of Tamoxifen and then switched to either the aromatase inhibitor Letrozole or placebo.
BIG 1-98
MA 17
TEAM
IES
Letrozole can also be used in the neoadjuvant setting.
True
False
What is the word for word tagline for Dracenax?
BONUS: Which 3 NCSM components must be mentioned in the Power Call?
Start with a patient type
Establish Needs
Deliver a Tailored Solution
Explore & Overcome Obstacle
Close for Concrete Action
Give one key message for Dracenax and convert this to a compelling benefit.
