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Oncology

Total questions: 24

Worksheet time: 27mins

Name
Class
Date
1.

(Letrozole) Dracenax is also indicated for triple positive postmenopausal breast cancer.

a)

True

b)

False

2.

Dracenax is indicated only for early postmenopausal HR positive breast cancer.

a)

True

b)

False

3.

Dracenax contains __ mg of Letrozole.

a)

25mg

b)

10mg

c)

2.5mg

d)

5mg

4.

What is the shelf life of Dracenax?

a)

24 months

b)

18 months

c)

36 months

d)

60 months

5.

Dracenax is a (a)   type of aromatase inhibitor

6.

Dracenax is contraindicated to the following except for one.

a)

Patients with known hypersensitivity to  or any Dracenax of its excipients

b)

Pregnancy and lactation

c)

Patients with severe hepatic impairment (Child-Pugh grade C)

d)

Women of postmenopausal endocrine status

7.

These are the most frequently reported adverse reactions of patients taking Dracenax.

a)

hot flushes

b)

arthralgia

c)

bone pain

d)

all of the above

8.

There is no dosage adjustment recommended for mild to moderate hepatic impairment for patients taking Dracenax.

a)

True

b)

False

9.

Where is Dracenax manufactured?

a)

Stein, Switzerland

b)

Berleben, Germany

c)

Kundel, Austria

10.

Dracenax has demonstrated efficacy in patients with hormone receptor negative breast cancer.

a)

True

b)

False

11.

There is no clinical experience to date on the use of Dracenax in combination of other anti-cancer agents.

a)

True

b)

False

12.

Dracenax can be used in which line of breast cancer treatment?

a)

Adjuvant treatment

b)

Extended adjuvant treatment

c)

First line treatment in advanced breast cancer

d)

Second line treatment in advanced breast cancer

e)

All of the above

13.

Dracenax inhibits the aromatase enzyme by competitively binding to the hem of the aromatase cytochrome P450, resulting in the rapid increase of estrogen biosynthesis in all tissues where present.

a)

True

b)

False

14.

Letrozole significantly reduced the overall risk of recurrence versus tamoxifen by how many percent in early breast cancer?

a)

18%

b)

19%

c)

20%

d)

25%

15.

What are the 2 landmark trials of Letrozole?

(a)  

16.

Encircle the options on the use of Letrozole in breast cancer.

a)

Upfront Letrozole for 5 years

b)

Upfront Letrozole for 3 years

c)

Tamoxifen for 2 year followed by Letrozole for 5 years

d)

Tamoxifen for 5 years followed by Letrozole for 5 years

e)

Upfront Letrozole for 10 years

17.

Letrozole reduced the overall recurrence by __% regardless of nodal status/prior chemotherapy in the extended adjuvant setting.

a)

45%

b)

56%

c)

42%

d)

40%

18.

Letrozole significantly reduced the risk of distant metastasis versus tamoxifen by how many percent in early breast cancer?

a)

30%

b)

27%

c)

28%

d)

35%

19.

___  is a multinational, phase 3, randomized, double blind, clinical trial conducted in more than 8,000 patients.

a)

TEAM

b)

IES

c)

ARNO

d)

BIG 1-98

20.

In the ___ study, patients with early-stage breast cancer receive 5 years of Tamoxifen and then switched to either the aromatase inhibitor Letrozole or placebo.

a)

BIG 1-98

b)

MA 17

c)

TEAM

d)

IES

21.

Letrozole can also be used in the neoadjuvant setting.

a)

True

b)

False

22.

What is the word for word tagline for Dracenax?

4 lines
23.

BONUS: Which 3 NCSM components must be mentioned in the Power Call?

a)

Start with a patient type

b)

Establish Needs

c)

Deliver a Tailored Solution

d)

Explore & Overcome Obstacle

e)

Close for Concrete Action

24.

Give one key message for Dracenax and convert this to a compelling benefit.

4 lines