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Dr. Corso Endocrine (ezgen 3 Pentosephosphate Pathway and Other

Total questions: 27

Worksheet time: 25mins

Name
Class
Date
1.

What glycolysis intermediate is the starting point for

the PPP?

a)

glucose

b)

glucose-6-phosphate

c)

fructose-6-phosphate

2.

What are the products of the non-oxidative phase of

PPP that return to glycolysis?

a)

glucose

b)

fructose-6-phosphate

c)

glyceraldehyde-3-phosphate

d)

glucose-6-phosphate

3.

Thiamine deficiency - which enzyme in the PPP is

dependent on thiamine?

a)

transketolase

b)

glucose-6-phosphate dehydrogenase

c)

6-phosphoglucanate dehydrogenase

4.

What is glutathoine  05 needed for?

a)

It is a building block of a protein

b)

It is an antioxidant needed to neutralize peroxide.

c)

It is an oxidizing agent needed to make ATP.

d)

It is needed as a component of hemoglobin

5.

A defect of the enzyme Glucose-6-phosphate

dehydrogenase most commonly causes.

a)

hemolytic anemia

b)

hypoglycemia

c)

hyperglycemia

6.

In G6PDD, what reducing equivalent  07 is missing?

a)

FADH2

b)

NADH

c)

NADPH

7.

 08 Which enzyme requires NADPH as a reducing agent?

a)

glutathione reductase

b)

PKF-1

c)

hexokinase

d)

ransketolase

8.

A well-nourished physician of Mediterranean heritage is suffering fatigue while

doing missionary work in Africa. This physician doesn’t have a history of heavy

alcohol consumption. Shortly after receiving an anti-malarial drug, symptoms

started to appear. Lab tests indicate low RBC’s and a urine test indicates the

presence of free hemoglobin. Which of the following conditions would best

explain these symptoms?

a)

Glucose-6-phosphate dehydrogenase deficiency

b)

Aldolase B

c)

Beta-galactosidase deficiency

9.

An alcoholic of northern European descent shows that he has borderline

hemolytic anemia. A blood test shows a decreased in the rate of the enzyme

transketolase, but a genetic test shows that there is no genetic defect with this

enzyme. Supplements with which vitamin is most likely to improve this patient’s

condition?

a)

Thiamine

b)

Vitamin A

c)

NIacin

d)

Biotin

10.

If a patient has G6PDD, which of the following would

be most helpful? Think about this, this is not a

memorization question.

a)

antioxidant vitamins

b)

breathing 100% oxygen

c)

drinking alcohol

d)

taking the drug primaquine

11.

In most tissues, how does fructose enter glycolysis?

a)

It is phosphorylated to fructose-6-phosphate by hexokinase

b)

It is isomerized to glucose

c)

It is converted to mannose

12.

In the liver, how does fructose enter glycolysis?

a)

It is phosphoryated to fructose-1-phosphate by fructokinase, then split by

aldolase

b)

It is phosphoryated to fructose-6-phosphate by hexokinase

13.

A patient has an aldolase B deficiency. What symtoms

would you expect?

a)

enlarged liver

b)

elevated glycogen in the liver

c)

fasting hypoglycemia

d)

fructose intolerance

14.

The prefered sugar in the eye is which of the

following?

a)

glucose

b)

fructose

c)

mannose

d)

galactose

15.

Elevated Sorbitol in the eye is associated with which of

following?

a)

cataracts

b)

color bindness

c)

night blindness

d)

far sightedness

16.

Galacitol is mostly associated with  06 which disorder?

a)

cancer

b)

cataracts

c)

heart attack

17.

What is the first step of metabolizing  07 galactose

a)

phosphorylation by galactokinase to galactose-1-phosphate

b)

phosphorylation by hexokinase to galactose-6-phosphate

18.

What is the first step of mannose metabolism?

a)

Phosphorylation by hexokinase

b)

Isomerization to fructose

19.

Which molecules are condensed to make lactose?

a)

glucose

b)

UDP-galactose

c)

galactose

d)

UDP-glucose

20.

is not conjugated, is

not water soluble

and travels through

the blood on

albumin

a)

Most indirect

bilirubin

b)

Most directbilirubin

21.

has glucuronates

attached and is

water soluble

a)

Most directbilirubin

b)

Most indirect

bilirubin

22.

Which of the following is an  11 epimer of glucose?

a)

galactose

b)

lactose

c)

ribose

d)

trehalose

23.

The reduced form of glucose is named?

a)

sorbitol

b)

fructose

c)

galactose

d)

ribose

24.

A patient with a liver Aldolase B deficiency would have problems tolerating which sugar?

a)

Fructose

b)

Glucose

c)

galactose

25.

A patient with galactosemia would have problems with:

a)

Cataracts

b)

Gout

c)

Kidney stone

26.

Sulfonylureas have which direct effects?

a)

increase the release of insulin form beta cells

b)

increase the release of insulin form alpha cells

27.

What are the most importnat Products of the pentose

phosphate pathway? (pick all that apply)

a)

AT

b)

NADPH

c)

ribose-5-phosphate

d)

glucose