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WorksheetsDr. Corso Endocrine (ezgen 3 Pentosephosphate Pathway and Other
Total questions: 27
Worksheet time: 25mins
What glycolysis intermediate is the starting point for
the PPP?
glucose
glucose-6-phosphate
fructose-6-phosphate
What are the products of the non-oxidative phase of
PPP that return to glycolysis?
glucose
fructose-6-phosphate
glyceraldehyde-3-phosphate
glucose-6-phosphate
Thiamine deficiency - which enzyme in the PPP is
dependent on thiamine?
transketolase
glucose-6-phosphate dehydrogenase
6-phosphoglucanate dehydrogenase
What is glutathoine 05 needed for?
It is a building block of a protein
It is an antioxidant needed to neutralize peroxide.
It is an oxidizing agent needed to make ATP.
It is needed as a component of hemoglobin
A defect of the enzyme Glucose-6-phosphate
dehydrogenase most commonly causes.
hemolytic anemia
hypoglycemia
hyperglycemia
In G6PDD, what reducing equivalent 07 is missing?
FADH2
NADH
NADPH
08 Which enzyme requires NADPH as a reducing agent?
glutathione reductase
PKF-1
hexokinase
ransketolase
A well-nourished physician of Mediterranean heritage is suffering fatigue while
doing missionary work in Africa. This physician doesn’t have a history of heavy
alcohol consumption. Shortly after receiving an anti-malarial drug, symptoms
started to appear. Lab tests indicate low RBC’s and a urine test indicates the
presence of free hemoglobin. Which of the following conditions would best
explain these symptoms?
Glucose-6-phosphate dehydrogenase deficiency
Aldolase B
Beta-galactosidase deficiency
An alcoholic of northern European descent shows that he has borderline
hemolytic anemia. A blood test shows a decreased in the rate of the enzyme
transketolase, but a genetic test shows that there is no genetic defect with this
enzyme. Supplements with which vitamin is most likely to improve this patient’s
condition?
Thiamine
Vitamin A
NIacin
Biotin
If a patient has G6PDD, which of the following would
be most helpful? Think about this, this is not a
memorization question.
antioxidant vitamins
breathing 100% oxygen
drinking alcohol
taking the drug primaquine
In most tissues, how does fructose enter glycolysis?
It is phosphorylated to fructose-6-phosphate by hexokinase
It is isomerized to glucose
It is converted to mannose
In the liver, how does fructose enter glycolysis?
It is phosphoryated to fructose-1-phosphate by fructokinase, then split by
aldolase
It is phosphoryated to fructose-6-phosphate by hexokinase
A patient has an aldolase B deficiency. What symtoms
would you expect?
enlarged liver
elevated glycogen in the liver
fasting hypoglycemia
fructose intolerance
The prefered sugar in the eye is which of the
following?
glucose
fructose
mannose
galactose
Elevated Sorbitol in the eye is associated with which of
following?
cataracts
color bindness
night blindness
far sightedness
Galacitol is mostly associated with 06 which disorder?
cancer
cataracts
heart attack
What is the first step of metabolizing 07 galactose
phosphorylation by galactokinase to galactose-1-phosphate
phosphorylation by hexokinase to galactose-6-phosphate
What is the first step of mannose metabolism?
Phosphorylation by hexokinase
Isomerization to fructose
Which molecules are condensed to make lactose?
glucose
UDP-galactose
galactose
UDP-glucose
is not conjugated, is
not water soluble
and travels through
the blood on
albumin
Most indirect
bilirubin
Most directbilirubin
has glucuronates
attached and is
water soluble
Most directbilirubin
Most indirect
bilirubin
Which of the following is an 11 epimer of glucose?
galactose
lactose
ribose
trehalose
The reduced form of glucose is named?
sorbitol
fructose
galactose
ribose
A patient with a liver Aldolase B deficiency would have problems tolerating which sugar?
Fructose
Glucose
galactose
A patient with galactosemia would have problems with:
Cataracts
Gout
Kidney stone
Sulfonylureas have which direct effects?
increase the release of insulin form beta cells
increase the release of insulin form alpha cells
What are the most importnat Products of the pentose
phosphate pathway? (pick all that apply)
AT
NADPH
ribose-5-phosphate
glucose
