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WorksheetsPharmaceutics 1 -Exam 2 - Dr. Mirza
Total questions: 29
Worksheet time: 15mins
Which of the following is used to measure flow properties of a powder?
Angle of repose
Wettability
density
void
The higher the angle of repose the more freely the powder flows.
True
False
Which of the following would have a greater wettability on a glass plate?
Mercury (spherical droplet)
Oil (hemispherical droplet)
Water (droplet spreads over the glass)
What are the forces acting on a liquid droplet in terms of wettability?
surface tension of the solid
surface tension of the liquid
solid/liquid interfacial tension
A contact angle of _______ is completely wettable but a contact angle of ______ is not wettable.
0, 90
90, 180
0, 180
180, 0
What is the process of transforming an amorphous solid to a crystalline solid?
Crystallization
Amorphization
Transformation
Hydration
Drying
What is the process of transforming a crystalline solid to an amorphous solid?
Crystallization
Amorphization
Transformation
Hydration
Drying
What is the process of transforming a crystalline polymorph 1 to a crystalline polymorph 2?
Crystallization
Amorphization
Transformation
Hydration
Drying
What is the process of transforming an anhydrous solid to a hydrate/solvate?
Crystallization
Amorphization
Transformation
Hydration
Drying
What is the process of transforming to a hydrate/solvate to an anhydrous solid?
Crystallization
Amorphization
Transformation
Hydration
Drying
Which of the following is a solvate?
Which of the following is a co-crystal?
Which of the following is a salt?
Which of the following is a polymorph 1?
Which of the following is a polymorph 2?
one anhydrate form is not bioavailable
Chloramphenicol palmitate
Carbamazepine
Enalapril maleate
therapeutic failure has been attributed to dihydrate formation
Chloramphenicol palmitate
Carbamazepine
Enalapril maleate
form I produces a toxic degradation product, form II does not
Chloramphenicol palmitate
Carbamazepine
Enalapril maleate
Bioavailability affects solid form development.
True
False
Which properties are affected by solid state forms?
Solubility
Dissolution rate
Stability
Rates of solid state reactions
The salt form may be used due to optical purity.
True
False
Co-crystals are crystalline molecular complexes of two or more neutral molecules, which are liquid under ambient conditions.
True
False
A pharmaceutical powder has the void of 0.45. What is the porosity of this powder?
55%
45%
4.5%
5.5%
Which of the following is the correct solubility order from least to greatest solubility?
amorphous< crystalline anhydrous< crystalline hydrate
crystalline hydrate< crystalline anhydrous< amorphous
amorphous< crystalline hydrate < crystalline anhydrous
Which of the following correctly describes the purpose of the BCS?
To differentiate drugs based on their chemical structure
To differentiate drugs based on their source
To differentiate drugs based on their aqueous solubility
To differentiate drugs based on their solubility and permeability
Which class of the BCS would a non-ionized molecule fall into?
Class 1- good solubility and permeability
Class 2 - good permeability and poor solubility
Class 3- good solubility and poor permeability
Class 4- poor solubility and permeability
Molecular weight affects solubility
True
False
The aqueous solubility of a new drug candidate was determined to be 200 microgram/mL. Which USP solubility category does this drug fall into?
Soluble
Very slightly soluble
Practically insoluble
Sparingly soluble
Slightly soluble
Which of the following does NOT affect the solubility of a solid?
Temperature
Crystal structure
Size of the solid particles
Stereochemistry
