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WorksheetsEndocrine Exam 3-Khan
Total questions: 22
Worksheet time: 13mins
Which of the following is the most potent estrogen?
Estradiol
Estrone
Estriol
Estrogens are _________ steroids
C18
C21
C16
C25
Progestins are _________ steroids
C18
C21
C16
C25
Which enzyme is needed to convert androstenedione to estrone and testosterone to estradiol?
Aromatase
Estradiol dehydrogenase
17α-hydroxylase
5α-reductase
Which enzyme is needed to convert between estradiol and estrone?
Aromatase
Estradiol dehydrogenase
17α-hydroxylase
5α-reductase
What is the source of estrogens?
Androgens
Ovaries
Placenta
Adipose tissues
Which is essential for estrogenic activity?
Aromatic A ring & OH group
Substitution at C1
Addition of OH at positions 6,7 and 11
Additional double bonds in the steroidal B ring enhances
Which enhances potency?
Aromatic A ring & OH group
Substitution at C1
Addition of OH at positions 6,7 and 11
Additional double bonds in the steroidal B ring enhances
Estradiol is promptly conjugated and metabolized when taken orally and therefore has high oral bioavailability and therapeutic effectiveness.
True
False
Which of the following is an orally active estrogen?
Mestranol
Ethinyl estradiol
Estradiol
Which of the following increases the half life of ethinyl estradiol?
hydroxyl group
alkyne group
aromatic ring
methyl group
Antibacterial agents can _________the efficacy of oral contraceptives due to bacteria in the GI tract hydrolyzing the glucuronide and
sulfate conjugates of EE
increase
decrease
Which of the following is a prodrug that is rapidly metabolized to EE?
Estradiol
Mestranol
Testosterone
Estrogen
Which of the following is true of esterified estrogen?
longer duration of action
shorter duration of action
IM injection
SC injection
Which of these are side effects of estrogenic compounds?
nausea
bloating
weight gain
elevated HTN
Breast tenderness
Estrogenic compounds have multiple black box warnings including increased risk of endometrial carcinoma and should not be used for prevention of CV disease.
True
False
What is essential for the antiestrogenic activity of clomiphene?
hydroxyl group
alkyne group
aminoalkyl ether
triphenylethylene
Clomiphene is used to prevent pregnancy.
True
False
Which are aromatase inhibitors?
letrozole
anastrozole
clomiphene
fluvestrant
Which of the following is contraindicated for estrogen use?
Thromboembolic disorders
Carcinoma of the breast
Osteoporosis
Undiagnosed genital bleeding
What is the major mechanism of contraceptive action of progesterone?
GnRH suppression
suppresses uterine contractility
increases body temperature
development of a secretory endometrium
Adverse effects of progesterone can include acne, headache, hirsutism, mood changes and depression.
True
False
