WorksheetsQuiz Anticancer Drugs, Haematinics & Plasma Expanders
Total questions: 40
Worksheet time: 23mins
Neoadjuvant chemotherapy is
chemotherapy drug given prior to the surgical procedure or radiation therapy
therapy that does not involve any drugs
chemotherapy drug given after the surgery or radiation therapy
chemotherapy drug administered as the only treatment
Which of the following drug acts as an alkylating agent?
5-fluorouracil
Cyclophosphamide
Doxorubicin
Vincristine
The anticancer agent that causes cell death due to deprivation of thymidine is
Actinomycin-D
6-mercatopurine
5-fluorouracil
Ifosphamide
The drug corresponding to letter ‘O’ in the CHOP regimen used for chemotherapy of lymphocytic leukemia is
Omalizumab
Ondansetron
Vincristine
Prednisone
Given below are the anticancer drug and their important and specific side effect. Choose the WRONG combination.
Bleomycin, Pulmonary fibrosis
Methotrexate, Syndrome of inappropriate antidiuretic hormone secretion
Doxorubicin, Cardiotoxicity
Cyclophosphamide, Haemorrhagic cystitis
The vinca alkaloids are a useful type of anti-cancer agents. Which of the following is true about these agents?
They are tyrosine kinase inhibitors
Paclitaxel and docetaxel are examples of vinca alkaloids
They do not cause myelosuppression or peripheral neuropathy
They all function by targeting the microtubules
In general, one should always consider that anthracycline drugs can cause myelosuppression and cardiotoxicity.
True
False
Dexrazoxane is useful to protect against cardiotoxicity caused by doxorubicin.
True
False
The anticancer drug that can completely cure choriocarcinoma is
Bleomycin
Carboplatin
Methotrexate
Vincristine
Which of the following drugs can be used most effectively against chemotherapy-induced nausea and vomiting?
Omeprazole
Ondansetron
Allopurinol
Leucovorin
Which of the following are Cell Cycle Non-Specific Anticancer Drugs?
Actinomycin D
Alkylating Agents
Platinum compounds
All of the answers
Tumour lysis syndrome (TLS) is a life-threatening oncological emergency. It is caused by the death, or lysis, of large numbers of cancer cells. Which drug can be used to treat this syndrome?
Ondansetron
Mesna
Allopurinol
L-Asparaginase
Which drug is used in the management and treatment of hemorrhagic cystitis associated with chemotherapy?
Allopurinol
Methotrexate
Mesna
Oncovin
A 42-year-old man with stage III Hodgkin’s disease received six courses of chemotherapy with the ABVD regimen. Which of the following drugs of this regimen acts mainly in the G2 phase of the tumor cell cycle?
Doxorubicin
Bleomycin
Vinblastine
Dacarbazine
A 6-year-old girl with acute lymphoblastic leukemia completed her induction therapy with a multidrug regimen. Now she is scheduled for maintenance therapy with a regimen that includes a cell cycle-specific anticancer drug. Which of the following is the drug she is about to receive?
Cisplatin
Doxorubicin
Mercaptopurine
Cyclophosphamide
The sources of drug information shown is a _______________ of drug information.
primary source
secondary source
tertiary source
The source of drug information in the picture is a _________________ source.
primary
secondary
tertiary
Which of the following is a secondary source of drug information?
WHO Model List of Essential Medicines
Indexing and abstracting systems
British Medical Journal
The picture shows ___________ source of drug information.
primary
secondary
tertiary
Primary sources for drug information refer to
bibliographic databases that provide abstract or full text of studies
unpublished studies and original articles published in reputed peer-reviewed journals
review articles published in reputed peer-reviewed journals
short indention of information with an adequate bibliographical citation
Which of the following parenteral iron is not given intravenously?
Iron dextran
Iron-sorbitol-citric acid complex
Iron-sodium gluconate complex
Iron- sucrose complex
Why is iron dextran given intramuscularly using Z track technique?
To avoid pain
To avoid anaphylactic reaction
To prevent staining of skin
To avoid joint pain
Which of the following increases absorption of iron from intestine?
Cyanocobalamin
Folic acid
Ascorbic acid
Erythropoietin
Pernicious anaemia occurs due to deficiency of:
Erythropoietin
Vitamin B12
Iron
Folic acid
Which of the following is used to treat thrombocytopenia?
Filgrastim
Sargramostim
Erythropoietin
Oprelvekin
What is the requirement of folic acid in pregnant women?
0.8mg/day
0.5mg/day
0.3 mg/day
1gm/day
An adverse effect of parenteral iron therapy is
Blackening of stool
Constipation
Gastric irritation
Pigmentation of skin
Dextran is a good plasma expander, but it has disadvantage of:
interfering in blood group matching
causing thrombocytopenia
decreasing microcirculation
promoting roleaux formation
Albumin is commonly used as plasma expander.
Which of the following is not true about albumin?
Used without regard to patient’s blood group
Carries the risk of hepatitis
Doesn’t interfere with coagulation
Causes hypersensitivity
Aromatase inhibitor is used to treat breast cancer because it
interferes with the action of estrogen once it has entered a cell
decreases the concentration of estrogen receptors
causes changes in shape of estrogen receptors
prevents the formation of estrogen
A patient if given 200 mg of a drug IV, and 100mg was eliminated during first two hours, how much will remian after 6 hours if the drug follows first-order kinetics?
25 mg
50 mg
75 mg
100 mg
Drugs that are highly bound to albumin:
effectively cross BBB
have large Vd
are easily filtered at the glomerulus
competes with other drugs for albumin binding drugs
If a drug is distributed into total body water, what dose is needed to obtain plasma level of 5mg/L in a 70 kg patient?
210 mg
50 mg
150 mg
35 mg
A woman is taking oral contraceptives. Which of the following drugs is unlikely to reduce the effectiveness of OC pills?
Carbamazepine
Phenytoin
Ketoconazole
Rifampicin
A 500mg of a drug has efficacy for 6 hours. If the half life of the drug is 8 hours, how long would a 1 gram be effective?
8 hours
12 hours
14 hours
16 hours
With IV infusion, a drug reaches 50% of its final steady state in 6 hours. The plasma half-life of the drug must be:
2 hours
6 hours
12 hours
24 hours
Which of the following is a phase II drug metabolism reaction associated with genetic polymorphism?
acetylation
oxidation
glucuronidation
glutathione conjugation
A sudden physical and neurophysiological change produced to abrupt stoppage of a drug with addiction liability is:
drug addiction
psychological dependence
withdrawal reactions
drug toxicity
If the effect of the combination of two drugs is more than the sum of their individual effects, the two drugs exhibit:
additive effect
cross tolerance
potentiation
synergism
The antidotal action of desferoxamine in iron poisoning is based on:
physical antagonism
chemical antagonism
physiological antagonism
pharmacological antagonism
