There are several clinical and historical features of disease that might suggest a primary immunodeficiency in any animal, including disease affecting a particular breed, littermates, chronic recurrent infections, failure to respond to vaccination, etc. While only 4 can be defined to the molecular level, how many canine immunodeficiencies are there in dogs?

There are 8 levels of primary immunodeficiencies. Which level has the worst prognosis?

The last level of primary immunodeficiencies is failure of production of one or more complement molecules. What is the most common complement deficiency?

Which of the following is not a level of primary immunodeficiencies?

Basset hounds, Welsh corgis, jack russell terriers (TCR and BCR receptor defect), Arab horses, and Angus calves are prone to this primary immunodeficiency that can be treated with bone marrow transplants, gene therapy, and transplant of heterologous stem cells.

If no serum IgM is present in foals, they could either have SCID, a selective IgM deficiency, or agammaglobulinemia which is

Nude mice, Mexican hairless dogs, Chinese crested dogs, and Birman kittens (in one reported case) are prone to a primary immunodeficiency in which they lack T lymphocytes linked to the failure of their hair coat development. What is this called?

In this primary immunodeficiency, lymphocyte dysfunction, subnormal plasma zinc levels, severe cutaneous parakeratosis, and reduced t cell mitogen response occurs. It also causes Acrodermatitis in Bull Terrier dogs, and affects Danish and Friesian cattle as well.

In Trapped Neutrophil Syndrome, cyclic hematopoiesis results in cyclic neutropenia, where a two week cycle causes normal neutrophil numbers and two weeks later there will be a decreased neutrophil number. What is the other neutrophil disorder in which there is defective neutrophil function and abnormal fusion of lysosomal membranes?

Which primary immunodeficiency has a mutation on integrin genes, is susceptible to multiple infections, and neutrophils can not migrate into tissues?

This primary immunodeficiency is associated with autoimmunity, allergies, or neoplastic diseases, causes mild chronic recurrent mucosal infections, may be associated with low levels of IgG in Shar Peis and Weimaraners, and causes a relative IgA deficiency in German Shepherds (respiratory infections).

Which primary immunodeficiency has a C3 and Factor H deficiency?

Which of the following is false regarding secondary immunodeficiencies?

Secondary immunodeficiencies are susceptible to infections, autoimmune diseases, and neoplasia. They have a decrease in CD4 T cells, a relative increase in CD8 T cells, and can be medically immunosuppressed by chemotherapy and immunosuppressive therapy. Which of the following is not an example of a secondary immunodeficiency?