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WorksheetsBilirubin metabolism
Total questions: 15
Worksheet time: 9mins
What is bilirubin?
A yellow-green pigment that is a product of RBC breakdown
A yellow-orange pigment that is a product of RBC breakdown
A green pigment that is a product of RBC breakdown
A brown pigment that is a product of RBC breakdown
What is the average lifespan of a red blood cell?
~100 days
~120 days
~200 days
~180 days
How do Red Blood Cells die?
They get inflamed
They rupture and release haemoglobin, which is then degraded
The shrivel and are digested by enzymes
The don't die
What type of cell breaks down haemoglobin?
Macrophages
Kupffer Cells
Lymphocytes
Neutrophils
What are the products of Haemoglobin breakdown
Bilirubin
Iron
Thrombin
Zinc
Enzymes involved in the formation of bilirubin
Heme Oxygenase
Heme Reductase
Biliverdin Reductase
Bilirubin Reductase
What is the intermediate product in the production of bilirubin?
Albumin
Bilirubin 2
Biliverdin
Urobillinogen
In what form is bilirubin transported as in blood?
Biliverdin-thrombin complex
Bilirubin-Thrombin complex
Bilirubin-albumin complex
Biliverdin-albumin complex
How does Bilirubin enter hepatocytes?
By osmosis
By active transport
By Facilitated diffusion
By passive diffusion
Role of Hepatocytes in bilirubin metabolism
Increases bilirubin solubility by conjugation: the addition of two molecules of glucuronic acid
Decreses bilirubin solubility by conjugation: the addition of two molecules of glucuronic acid
How is Bilirubin secreted into bile?
By facilitated diffusion vis bile canaliculi
By active transport via the bile canaliculi
By active transport via sinusoid
By Facilitated diffusion via sinusoid
How is Urobilinogen formed?
Conjugated bilirubin is hydrolysed and reduced by bacteria
Conjugated bilirubin is hydrolysed and oxidised by bacteria
Unconjugated bilirubin is hydrolysed and oxidised by bacteria
Unconjugated bilirubin is hydrolysed and reduced by bacteria
How many metabolic pathways are there for urobilinogen
3
2
1
5
What is Jaundice
Excess urobilinogen in extracellular fluid
Excess bilirubin in extracellular fluid
Excess bilirubin in intracellular fluid
Excess urobilinogen in intracellular fluid
What are the common causes of jaundice
Increased destruction of Red Blood Cells
Obstruction of Bile Ducts
Damage to Hepatocytes
decreased urobilinogen production
